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Antibody Discovery and Characterization

National Center for Advancing Translational Sciences, Bethesda, MD and surrounding area

Position Description:

The National Center for Advancing Translational Sciences (NCATS), one of the centers at the National Institutes of Health (NIH), is looking for candidates to hold a post-doctoral position in antibody discovery and characterization at its Rockville-Maryland location. Part of our mission is the development of new therapeutic approaches in areas of medical need.  We partner with external collaborators specialized in specific disorders creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics, and various “-omics” technologies. 

The selected post-doctoral fellow will work in an interactive laboratory environment. S/he will implement antibody discovery technologies, including phage display, directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to  pain, addiction, and overdose, as well as other public health emergencies, such as the novel coronavirus (SARS CoV-2) pandemic. The incumbent will apply cutting-edge cell biology and bioassay technologies for the development of disease relevant antibody selection and screening assays and will be involved in all aspects of the implementation including assay design, assay development and optimization, antibody screening, protein engineering, data analysis, and mechanism of action studies for the development of novel biologicals.

The candidate should be able to work independently under team supervision. The incumbent will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. S/he will draft technical reports, and manuscripts and present work internally and to external collaborators as needed. S/he will work under the mentorship of a biology team leader and be exposed to cutting-edge high-throughput screening (HTS), assay biology, bioinformatics, medicinal chemistry, and disease-relevant biological models.

Qualifications:

Position requires a Ph.D. degree with zero to three years of post-doctoral experience in in cell biology, molecular biology, pharmacology, or related discipline. Candidates about to complete their doctoral training will be considered. Experience with antibody phage display technologies, including panning, ELISA, and protein purification is required. The candidate should be an independent thinker and team player able to work in a very interactive high pace environment.

To Apply:

Applicants must be eligible to work in the US for any employer. Applications will be accepted until the position is filled. Applicants should send their cover letter, CV including bibliography, and arrange for three letters of reference to be sent to: NCATSantibody_hiring@nih.gov

 

This post will be available until July 29, 2020 or until filled.

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