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Immune Dysregulation and Cancer in Aging

National Institute on Aging, Intramural Research Program, Baltimore, MD

Position Description:

If you enjoy science and your goal is to eventually create an independent research program, the Immunoregulation Section of the National Institute on Aging (NIA) is a great place for you. You will join a highly motivated and international team of young scientists elucidating immune dysregulation in aging-related pathologies and diseases. The team is known for their discovery of a unique type of regulatory B cells (tBregs), which promote cancer metastasis by inactivating Tregs and activating MDSCs [1, 2, 3], and pathogenic innate B1a cells (termed 4BL cells), which accumulate in aged humans, primates, and mice [4, 5] and induce insulin resistance [6], and creation of simpler technologies to manipulate immune cells utilizing modified chemo-attractant molecules [7].

We are looking for a highly motivated and independent-minded person to study crosstalk between commensal microbiome and B cells in modulation of cancer metastasis in aging. We recently reported that the change in composition of gut microbiome in aging increases gut leakiness and induces conversion of innate B1a cells into pathogenic 4BL cells via inflammatory monocytes [6]. 4BL cells then either retard growth of some tumors by inducing cytolytic CD8 T cells or increase of insulin resistance in aged hosts. However, the mechanism that drives the change in gut microbiome remains unknown. Question is whether 4BL cells in turn or its “relative” B1b cells affect microbiome? If so, what is the mechanism, is it via B-cell produced humoral factors, including immunoglobulins, or indirectly through modulation of GALT immune cells? Why despite increase of 4BL cell-induced CD8 T cells, progression and metastasis of most tumors is increased in aging? Can we reverse this process by supplementing with gut microbes or their metabolites decreased in aging? Overall, this truly exciting and novel project will uncover a plethora of interesting findings that will help you to make significant impact in science.

Qualifications:

Applicants must have a Ph.D. or equivalent degree and expertise in Immunology, Molecular Biology, Microbiology, and (preferably with a hands-on knowledge of Neuro-inflammation and Mucosal immunity). Bioinformatics know-how and experience with experimentations with mice and handling human and primate samples will be advantageous.

To Apply:

To apply, please submit letter of interest, curriculum vitae, and references to: Arya Biragyn, Ph.D., Chief, Immunoregulation section, NIH/NIA/IRP, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224 USA. Office phone: 410-558-8680, or e-mail: biragyna@mail.nih.gov

 

This post will be available until September 3, 2020 or until filled.

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