Skip to Content

Cell Biology – The Ubiquitin-Proteasome System In Health And Disease

National Cancer Institute, Frederick, MD

Position Description:

A postdoctoral position is available in the Weissman group in the Laboratory of Protein Dynamics and Signaling (LPDS) to study regulatory roles of the ubiquitin-proteasome system at the endoplasmic reticulum and mitochondria. Research directions relate to dissecting the roles of the ubiquitin system in processes such as lipid metabolism, the innate immune response, cellular stress responses, and protein quality control.  Goals are to understand how these and other regulated pathways relate to normal cellular function and contribute to pathological states including: cancer growth and metastasis, viral pathogenicity, and cardiovascular disease. An additional area of interest in the group is on structure-function relationships for RING-type ubiquitin protein ligases (E3s) and their interactions with ubiquitin conjugating enzymes (E2s). Research in LPDS routinely employs state of the art cell biological, biochemical, biophysical, proteomic and genetic approaches. In vivo systems utilized include mammalian cell culture, yeast, and mouse models, and findings are correlated with patient samples curated by our collaborators.

The LPDS is part of the Center for Cancer Research (CCR) of the National Cancer Institute (NCI) and is located on the Frederick Maryland Campus of the NCI. LPDS trainees have access to a unique range of NCI core facilities located in Frederick and to the immense breadth of expertise characteristic of the NCI intramural program. We collaborate and interact extensively with scientists throughout the NIH Intramural Program.

For additional information, please visit:


  • Applicants should be completing, or have recently completed, a PhD or have an MD with limited relevant post-doctoral training. Appointees may be U.S. citizens, U.S permanent residents, or non-US residents eligible to obtain a valid employment authorization visa.
  • Applicants should have demonstrated expertise in cell biology and biochemistry. A working knowledge of the ubiquitin-proteasome system is a plus.

To Apply:

Applicants should send an email that includes a letter of interest, CV and Bib, and names of three references to Dr. Allan Weissman Please write “Postdoctoral” application in the subject heading.


This post will be available until September 4, 2020 or until filled.

This position is subject to background investigation.

The NIH is dedicated to building a diverse community in its training and employment programs.