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Gene Regulation In Single Cells: A Long-Read Sequencing Project

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD and surrounding area

Position Description:

A Postdoctoral Fellowship is available to study gene regulation in single cells using a novel long-read sequencing approach to measure DNA accessibility. Chromatin remodelers and epigenetic factors regulate DNA accessibility and gene expression. The project will build on our recent studies showing that DNA accessibility varies from cell to cell (Chereji et al. (2019) Genome Research, PMID: 31511305). The lab is primarily interested in investigating the roles of ATP-dependent chromatin remodeling machines, such as the SWI/SNF complex, in determining accessibility of promoter DNA, using yeast and mouse as model systems. Mutations in genes encoding subunits of these remodeling complexes are commonly found in cancer and are associated with other diseases.

Further details and a list of publications can be found at:

https://www.nichd.nih.gov/about/org/dir/affinity-groups/BMGR/clark

Qualifications:

Interested candidates must have a Ph.D. and a strong background in molecular biology and/or computational biology.

To Apply:

Please submit a cover letter, curriculum vitae, bibliography and names of three references to:

Dr. David J. Clark
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 6A Room 2A02, 6 Center Drive, Bethesda MD 20892
 
 
 
This post will be available until september 12, 2020 or until filled.

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