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Organelle Biogenesis and Lipid Homeostasis

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD and surrounding area

Position Description:

Our laboratory uses a combination of biochemistry, microscopy, and high-throughput screening to elucidate the principles of organelle biogenesis and lipid homeostasis. We are particularly interested in the role of endoplasmic reticulum subdomains in organelle biogenesis and regulating lipid metabolism. Understanding how these subdomains form and function is not only an important problem in cell biology but is also critical for understanding cellular dysfunctions that occur in a number of diseases, particularly lipid metabolic disorders. There are two related projects in the lab. In the first, we are working to understand how membrane contact sites form or disassemble in response to cellular stresses and how these sites function in intracellular lipid trafficking and metabolism. In the second project, we are investigating how specialized domains in the ER mediate the formation of lipid droplets, lipoproteins, and peroxisomes. We are particularly interested in lipoprotein formation and trafficking in hepatocytes and how these processes go awry in disease.

NIDDK has excellent training opportunities to interact with other laboratories and numerous core facilities, including an Advanced Light Microscopy and Image Analysis Core, Advanced Mass Spectrometry Core, Cryo-Electron Microscopy Core, and a Genomics Core.

Qualifications:

Seeking applicant with an interest in lipid and membrane biochemistry, advanced imaging, bioinformatics and/or lipid metabolism.

Candidates must have a PhD or an MD degree awarded within the past 5 years.

To Apply:

Applicants should send an email that includes a letter of interest, CV and Bib, and names of three references to Will Prinz, wp53m@nih.gov.

 

This post will be available until October 10, 2020.

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