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Cell Biology of the Nucleus

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD and surrounding area

Position Description:

We are seeking a highly motivated postdoctoral fellow for a position in the Division of Molecular and Cellular Biology. The nuclear pore complex (NPC) is a multiprotein channel through the nuclear envelope that permits selective transport of macromolecules between the nucleus and cytoplasm. Beyond nucleocytoplasmic trafficking, the NPC plays important roles in chromosome organization, transcriptional control, RNA processing, and cell-cycle control. The project will utilize CRISPR/Cas9-based methods to analyze the function of nucleoporins, individual constituent proteins of the NPC. The project will also employ a range of other cell biological, bioinformatic and biochemical approaches, and may use Drosophila melanogaster as a model genetic system to analyze nucleoporin function. The long-term goal of this project is to understand physiological roles of individual nucleoporins and how disease-associated mutations in NPC subunits cause human pathology.

The Division of Molecular and Cellular Biology provides an excellent training environment, with a vibrant, multi-disciplinary community of biologists studying many aspects of molecular, cellular and developmental biology. We are part of the NICHD Intramural Program, which offers a wide variety of training opportunities, excellent core support and access to a diverse array of biomedical studies within the NIH Bethesda campus.

Chen et al. (2020). Anchorage of RanGAP to the Nuclear Pore Complex is Required for Development in Drosophila (submitted).

Aksenova et al. (2020). Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway (submitted). See also: bioRxiv 685263. doi: https://doi.org/10.1101/685263.

Yau et al. (2020). RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics. Cell Cycle 19: 1899-1916.

Qualifications:

Candidates should hold a doctoral degree in cell biology, biochemistry or a related field, with demonstrated productivity and less than five years of postdoctoral experience. Recent graduates are encouraged to apply.

To Apply:

For more information, please contact Mary Dasso (dassom@mail.nih.gov). To apply, please email CV, summary of research interests and three letters of reference to the same address.

Application Deadline: This post will be available until October 1, 2020 or until filled.

NIH is an Equal Opportunity Employer. The NIH is dedicated to building a diverse community in its training and employment programs.