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ICF4 Syndrome and Chromatin States During Development

National Cancer Institute, Frederick, MD

Position Description:

The Epigenetics Section, headed by Dr. Kathrin Muegge has an open post-doctoral position. The Epigenetics Section study the causes and consequences of the ICF4 syndrome, a complex disease with symptoms of immunodeficiency, genomic instability, mental retardation and compromised germ cell development. Genetic mutations of Lsh/HELLS, a chromatin remodeling protein, can cause the ICF4 syndrome. Lsh modulates genome wide chromatin accessibility, influences DNA methylation levels and alters retrotransposon expression. Using mouse models with tissue specific deletions of Lsh we are using a variety of molecular and cell biologic techniques to determine chromatin states in affected tissues during development. Uncovering molecular pathways will deepen our understanding of the pathophysiology underlying this disease and should help to identify novel molecular targets for therapeutic intervention.

Please visit Dr. Muegge’s webpage for further information:


Applicants must have a Ph.D. degree and expertise in molecular biology, genetics, biochemistry, and cell biology. We are looking for a candidate who possess an exceptional motivation for academic research and less than 1year postdoctoral experience. Those with experience in germ cell development, neurobiology and epigenetics are particularly encouraged to apply. Good oral and written communication skills are required.

To Apply:

Applications, sent by e-mail to, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information for three references (including the current supervisor).


This post will be available until December 22, 2020 or until filled.

This position is subject to a background investigation.

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