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Transgenic Mouse Modeling

National Institute of Environmental Health Sciences, Research Triangle Park, NC

Position Description:

We recently demonstrated that missense mutations in the gene SMCHD1 (Structural maintenance of chromosomes flexible hinge domain-containing protein 1) are the main genetic driver of congenital arhinia, an extremely rare craniofacial malformation (Shaw et al. Nature Genetics 2017).  SMCHD1 is a master epigenetic repressor that silences both X-linked and autosomal genes and plays a role in DNA damage repair. To understand the functional consequences of these mutations and to identify modifier loci, we are using a multi-pronged approach that includes genomic, proteomic, and molecular biology studies in patient-derived neural stem cells, transgenic mouse modeling, and structural biology.

We are seeking a highly motivated, passionate, and talented individual to lead our transgenic mouse program, which involves mouse breeding, genotyping, embryo phenotyping, as well as functional studies (e.g., biochemical, transcriptomics, metabolomics, and proteomics) in mouse neural stem cells.

Applicants must have a doctoral level degree with no more than five years of postdoctoral research. Experience and/or interest in cell biology, biochemistry, genetics, epigenetics, and mouse embryology or developmental biology is strongly recommended. We are looking for an applicant who is highly motivated, enthusiastic, passionate about his/her work, and who works well with others.  The applicant should be capable of conducting research with limited supervision and have strong oral and written communication skills. 

This posting is for a one-year position with the intent to renew in 1-year increments. Competitive salaries are determined by educational degree(s) and number of years of relevant postdoctoral experience.

Employer Name:

Clinical Research Branch
Pediatric Neuroendocrinology Group

Position Location:

111 TW Alexander Drive|
Research Triangle Park, North Carolina 27709

To Apply:

Please email a cover letter, curriculum vitae with list of publications in peer-reviewed journals, and the names and contact information of 3 references to: Natalie Shaw, MD,

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