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Noncanonical Ribosome Functions in Cellular Stress Response

National Cancer Institute, Frederick, MD

Position Description:

A fully funded postdoctoral fellow position is available in Dr. Colin Wu’s lab within the RNA Biology Laboratory at the National Cancer Institute (NCI) in Frederick, MD at the National Institute of Health (NIH). The major focus of the laboratory is to investigate the molecular mechanisms of translational regulation and non-canonical functions of the ribosome in mammalian systems.

Multiple projects are available: (1) developing and applying high-throughput sequencing approaches to characterize in vivo dynamics of the ribosome and RNA-binding proteins; (2) exploring non-canonical functions of the ribosome in signal transduction; (3) characterizing local translation-coupled RNA decay and protein quality control. The position offers rigorous training opportunities in multiple disciplines to build a new high impact research program. Visit our website for more information: https://ccr.cancer.gov/RNA-Biology-Laboratory/colin-c-c-wu

Recent relevant publications:

  1. Ribosome collisions trigger general stress responses to regulate cell fate. Cell. 2020
  2. High-resolution ribosome profiling defines discrete ribosome elongation states and translational regulation during cellular stress. Mol Cell. 2019
  3. eIF5A functions globally in translation elongation and termination. Mol Cell. 2017

Qualifications:

Applicants should hold a Ph.D. and/or M.D. degree. Students who expect to receive their degree are encouraged to apply. While expertise in RNA biology, cell biology, or molecular biology is desirable, highly curious candidates from other areas who are enthusiastic about learning new skills are encouraged to apply. The position is available immediately and subjected to a background investigation.

To Apply:

To be considered, please send the following materials to Colin Wu: colin.wu2@nih.gov:

  1. Brief cover letter including long-term career goals
  2. CV including research interests and bibliography
  3. Contact information of three references

 

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