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Genomic Toxicology

National Center for Advancing Translational Sciences, Division of Preclinical Innovation, Bethesda, MD and surrounding area

The National Center for Advancing Translational Sciences (NCATS), the newest of the 27 Institutes and Centers at NIH, was established in 2012.  The mission of NCATS is to transform translational science to get more treatments to more patients more quickly.  NCATS defines translational science as the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process. NCATS focuses on what is common across diseases and the translational process, emphasizing collaboration, innovation, deliverables, and team science. 

The Division of Pre-Clinical Innovation (DPI) is the intramural (i.e. on-site) research program of NCATS and is located in Rockville, Maryland, a few miles from the main NIH campus in Bethesda, MD.  DPI focuses on early stages of the translational process, from target validation to first-in-human studies.  Over 200 scientists from a variety of disciplines, and across the spectrum of early-career to senior leaders, are responsible for advancing the diverse research portfolio of DPI.  In addition to conducting cutting-edge laboratory research, DPI scientists collaborate with over 250 research organizations world-wide.

DPI scientists work in a collaborative, team-based environment.  The postdoctoral candidate will be recruited to work on the specific project described below but will have opportunities to collaborate with scientists both within and outside of NCATS on additional projects.  The candidate is expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals.

Position Description:

The National Center for Advancing Translational Sciences (NCATS), a major research component of the National Institutes of Health, is seeking an exceptional scientist to apply genomic tools to toxicology and pharmacology.  The Genomic Toxicology Lab participates in the Toxicology in the 21st Century (Tox21) Consortium by developing methods to assess the effects of chemicals on human health.

The selected candidate will complete development and implement a novel high-throughput screening method that quantifies expression of selected genes in cultured mammalian cells. The unprecedented throughput of this method will enable screening of large chemical libraries of environmental toxicants, or drug candidates. Because quantitative high-throughput screening of large chemical libraries is NCATS’ core expertise, there are abundant collaborative opportunities to apply this method to identify drug candidates, and to screen Tox21 toxicant libraries.

This laboratory also develops novel human cellular 3-D and co-culture models to study cardiovascular disease (CVD), as well as neurological and renal disease. The successful applicant will work with collaborators who have developed induced Pluripotent Stem Cell (iPSC)-derived endothelial cells, as well as 3-D endothelial cell models that incorporate shear flow and co-culture with vascular smooth muscle cells.

Within NCATS’ Division of Preclinical Innovation, we collaborate closely with scientists in, the 3-D Tissue Bioprinting Lab and the Stem Cell Translational Lab, as well as Therapeutics development labs, other NIH Centers, and academic scientists. NCATS excels due to these fruitful collaborations and enthusiastic support by core group experts including Informatics, Compound Library Management, and Automation.

Qualifications:

  • Ph.D. in a relevant field of molecular or medical biology
  • Strong publication record
  • Molecular biology and mammalian cell culture skills are required
  • Strong communication skills in written and spoken English.
Preferred:
  • Familiarity with vascular biology, or high-throughput screening is an advantage.

Applicants must be US citizens, legal residents, or possess a valid work permit, in order to be considered for the position.

To Apply:

Please send a cover letter, that specifically addresses why you're interested in this position, a CV with bibliography, and names and contact information for three references to (David Gerhold, NIH–NCATS, NCATSGenomicTox@mail.nih.gov, Laboratory profile).

 

This post will be available until May 10, 2021 or until filled.

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