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Mechanisms Underlying Neuronal Activity

National Institute of Neurological Disorders and Stroke, Bethesda, MD and surrounding area

Position Description:

Projects focus on the mechanisms underlying neuronal activity using GnRH neurons as the model system. In vivo, GnRH neurons, spread throughout the forebrain, release GnRH in a pulsatile fashion to control reproduction. In explants, primary GnRH neurons continue to release in a pulsatile fashion and show synchronized calcium oscillations. Projects utilize the GnRH system to study molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) and correlate activity with secretion.

Recent work:
  • Constantin S, Wray S. Nociceptin/Orphanin-FQ inhibits gonadotropin releasing hormone neurons via G-protein gated inwardly rectifying potassium channels. eNeuro. 2018 Dec 26;5(6).
  • Constantin S, Reynolds, D. Oh, A, Pizano K, Wray S. Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment. PNAS, 2021.


The successful candidate must have an Ph.D., M.D. or D.O. degree or equivalent, and relevant training in Neurobiology, Neuroendocrinology, Molecular biology, or Developmental biology. The candidate must be less than 2 years out from obtaining their Ph.D. Descriptions of the projects performed in research areas are indicated above.

Candidates with experience in calcium imaging or electrophysiology, molecular biology and mouse anatomy preferred but not mandatory.

To Apply:

Interested applicants should email Dr. Susan Wray ( an updated C.V. and cover letter. The position is available now and will remain open until filled.

This post will be available until May 10, 2021 or until filled.

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