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Preclinical Development

National Center for Advancing Translational Sciences, Bethesda, MD and surrounding area

Position Description:

NCATS seeks applications from qualified candidates to fill a Postdoctoral Fellowship position in the intramural laboratories of the Therapeutic Development Branch (TDB) within the Center’s Division of Preclinical Innovation. NCATS routinely partners with external collaborators from universities, pharmaceutical, biotech companies, and disease research foundations to form multidisciplinary project teams with expertise in assay development, high-throughput screening (HTS), bioinformatics analysis, medicinal chemistry, disease-relevant biological models, and preclinical drug development. As such, the TDB biology group is looking for a self-motivated postdoctoral fellow to work in a highly creative and collaborative team environment to advance drug discovery and drug development projects. Research conducted by members of the TDB biology group has a broad focus and spans multiple disease areas, including genetic diseases (e.g., lysosomal storage disorders, neuronal diseases, cancer, and infectious diseases).

Core Responsibilities:

The fellow will develop in vitro biochemical and cell-based assays for HTS of compound libraries to identify lead compounds, which will be used as tools to further understand disease pathophysiology and to be developed as therapeutics. He or she will learn and participate in the drug discovery/development process and will apply new technologies—including patient induced pluripotent stem cell (iPSC)-based disease models and high content phenotypic profiling—using cell-based imaging assays for evaluating drug efficacy and toxicity. Interrogation of drug mechanisms of action and proof-of-concept studies also will be undertaken. The fellow will collaborate with researchers in other universities and NIH Institutes/Centers and present experimental findings at scientific conferences. After the fellow’s training is completed, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities.

The fellow will communicate results to project team members and collaborators and provide updates to senior management. He or she will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. The fellow will write technical reports, manuscripts, and patent applications.

The incumbent is required to possess excellent interpersonal skills, including the ability to clearly and succinctly communicate in a timely manner, and a proven ability to foster important relationships with Division colleagues and external collaborators. He or she must maintain integrity and accuracy of project information to meet project requirements, using project management software such as Microsoft Teams. The incumbent also is required to speak and write clearly and effectively and to work collaboratively with colleagues to achieve the project, team, and organizational goals.

Qualifications:

The ideal candidate will possess a doctoral degree (i.e., Ph.D.) with a background in biology, molecular biology, or pharmacology and have a strong record of high-impact publications. Experience in stem cell research (especially iPSC-derived cells) or drug screening is helpful. The fellow can be trained in these areas. Candidates should be independent thinkers and team players who can work in an interactive and high-paced environment. Candidates are expected to present results of ongoing work at meetings (such as internal group meetings and national conferences) and submit their work for publication in scientific journals. Therefore, effective communication and presentation skills are required.

Salary/Benefits:

The current salary range is commensurate with experience in accordance with the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow Stipend Ranges for All Areas; health insurance benefits are available. The fellow can take part in Foundation for Advanced Education in the Sciences courses at the NIH as well.

To Apply:

Please submit a cover letter describing your interest in the position, including a career synopsis (1–3 pages); a current curriculum vitae and complete bibliography; and the names and contact information of three references ATTN: Kirill Gorshkov, Ph.D., at NCATSTDBBioHiring@mail.nih.gov. The position will remain open for 60 days (beginning Feb. 12, 2021). Learn more about intramural research at NCATS.

Application Deadline Date: April 12, 2021

 

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