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Pathogenic Role of B Cells in Alzheimer’s Disease

National Institute on Aging, Baltimore, MD

Position Description:

The role of B cells in Alzheimer’s disease remains poorly understood. Although immunoglobulins that target amyloid beta may interfere with formation and thus progression of the disease, recently we have made a counterintuitive finding that B cells promote manifestation of Alzheimer’s disease (Ki et al., Nature Communications, 2021, In press). To elucidate the mechanism of this process and to develop simpler immunotherapeutics tailored for elderly people with Alzheimer’s disease, the Immunoregulation section at the National Institute on Aging is seeing an ambitious and motivated person. The work will involve modeling studies in transgenic mice, flow cytometric evaluation of immune cells, immune fluorescent staining of murine and human tissues, and use of genetic engineering and protein purification tools.  

The laboratory is located in Baltimore, MD. For information about the laboratory, please visit https://irp.nih.gov/pi/arya-biragyn. About life in Baltimore, please visit https://www.southernmanagement.com/blog/what-is-it-like-to-live-in-baltimore-maryland

Qualifications:

Applicants must have a PhD. and /or M.D. degree (or anticipate receiving their degree in the near future) with less than five years of postdoctoral experience. Applicants should have the ability to carry out independent research, a strong interest in interdisciplinary approaches and collaborative research and have published articles in peer-reviewed journals. Training in molecular biology, immunology, biochemistry or neuroscience is preferred. NIH offers excellent salary and health care packages to its trainees and has consistently been ranked among the best places to work for postdoctoral fellows.

To Apply:

To apply, please submit letter of interest, curriculum vitae, and references to: Arya Biragyn, Ph.D., Chief, Immunoregulation section, NIH/NIA/IRP, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224 USA. Office phone: 410-558-8680, or e-mail: biragyna@mail.nih.gov.

 

This post will be available until May 18, 2021 or until filled.

This position is subject to a background investigation. DHHS, NIH and NCI are Equal Opportunity Employers.

The NIH is dedicated to building a diverse community in its training and employment programs.