Skip to Content

Gut Microbiota and Immunology of Aging

National Institute on Aging, Baltimore, MD

Position Description:

We recently reported that gut microbiota in aging induces conversion of B1a B cells into pathogenic 4BL cells and increases insulin resistance [1]. However, the mechanism that drives the change of gut microbiota remains unknown. The immunoregulation section of the National Institute on Aging (NIA) is seeking a highly motivated person to study the mechanism driving change of gut microbiota in aging. You will join an international team of young scientists working on immune dysregulation in aging-related pathologies [2, 3]. The work will involve modeling studies in transgenic mice, flow cytometric evaluation of immune cells, immune fluorescent staining of murine and human tissues, and use of genetic engineering and bioinformatics tools.  

The laboratory is located in Baltimore, MD. For information about the laboratory, please visit https://irp.nih.gov/pi/arya-biragyn. About life in Baltimore, please visit https://www.southernmanagement.com/blog/what-is-it-like-to-live-in-baltimore-maryland

Reference:
  1. Bodogai M, O'Connell, J , Kim, K, Kim, Y, Moritoh, K, Chen, C, Gusev, F, Vaughan, K, Shulzhenko, N,  Mattison, JA, Lee-Chang, C, Chen, W, Carlson, O, Becker, KG, Gurung, M, Morgun, A, White, J, Meade, T, Perdue, K, Mack, M, Ferrucci, L,Trinchieri, G, de Cabo, R, Rogaev, E, Egan, J, Wu, J, and Biragyn, A Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells Science Translational Medicine 2018, 10:In Press.
  2. Lee-Chang C, Bodogai M, Moritoh K, Olkhanud PB, Chan AC, Croft M, Mattison JA, Holst PJ, Gress RE, Ferrucci L et al: Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity. Blood 2014, 191(8):4141-4151.
  3.  Lee-Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, Young HA, Croft M, Ferrucci L, Biragyn A: Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. J Immunol 2016, 196(8):3385-3397.

Qualifications:

Applicants must have a PhD. and /or M.D. degree (or anticipate receiving their degree in the near future) with less than five years of postdoctoral experience. Applicants should have the ability to carry out independent research, a strong interest in interdisciplinary approaches and collaborative research and have published articles in peer-reviewed journals. Training in Molecular biology, Microbiology or Immunology (preferably with a hands-on knowledge of Mucosal immunity).  is preferred. NIH offers excellent salary and health care packages to its trainees and has consistently been ranked among the best places to work for postdoctoral fellows. The laboratory is located in Baltimore, MD.

To Apply:

To apply, please submit letter of interest, curriculum vitae, and references to: Arya Biragyn, Ph.D., Chief, Immunoregulation section, NIH/NIA/IRP, Biomedical Research Center, 251 Bayview Blvd, suite 100, Baltimore, MD 21224 USA. Office phone: 410-558-8680; e-mail: biragyna@mail.nih.gov.

 

This post will be available until May 18, 2021 or until filled.

This position is subject to a background investigation. DHHS, NIH and NCI are Equal Opportunity Employers.

The NIH is dedicated to building a diverse community in its training and employment programs.