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Cancer Biology - Regulation of Tumor Cell Metabolic and Bioenergetic Activities by Inositol Pyrophosphate Signals

National Institute of Environmental Health Sciences, Research Triangle Park, NC

Position description:

Metabolic rewiring is a crucial hallmark of cancer. Tumor cells consistently reprogram metabolic pathways to sustain an appropriate supply of energy and anabolic precursors that together serve an elevated proliferative capacity. A key goal of research in the field is to gain mechanistic understanding of how cancer cell metabolism becomes reprogrammed, so as to design new therapeutic interventions. We have recently published that inositol pyrophosphate cellular signals supervise tumor cell metabolic and bioenergetic activity; we are now investigating the molecular mechanisms and expanding the study to animal models. A fully-funded postdoctoral position is available to join our Inositol Signaling team to augment this research effort.

We are particularly interested in recruiting an individual who is interested in taking advantage of our novel kinase knock-in animal models. While this project’s main emphasis is on cancer biology, the work is also relevant to diabetes, obesity and cardiovascular diseases. Our group is part of the Signal Transduction Laboratory at NIEHS, which benefits from outstanding funding, and state-of-the art equipment that include ready access to excellent core facilities; several other scientific institutes in the local area amplify the collegial research environment.

For our recent publications, and for links to more information about our group, see:


Applicants must be very close to obtaining or have a Ph.D. and/or M.D. with < 5 years of postdoctoral training. The preferred candidate will have excellent writing and communication skills, a strong work ethic, and must be the first author of at least one peer-reviewed publication. Preference will also be given to candidates who have studied in the field of signal transduction, and have experience in the use of mouse models, and the various tools of molecular- and cellular-biology.

To Apply:

Please email a CV, which should include contact information for three referees, to

Dr. Stephen Shears.
Inositol Signaling Group,
National Institute of Environmental Health Sciences,
Research Triangle Park, North Carolina.


This post will be available until May 18, 2021 or until filled.

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