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Immunology

National Institutes of Health Collaboration with Purdue University, Bethesda, MD and surrounding area

Position Description:

One or two postdoctoral positions are available (open until filled) for enthusiastic scientists to work in the area of adaptive immunity. The posts are part of a multi-disciplinary collaboration between wet and dry labs at Purdue University (Kazemian lab) and the NIH (Afzali lab). These labs focus on the coding and non-coding regulatory circuitries underlying immune cell fate decisions, their relationship to tissue inflammation/repair, infectious diseases and cancer development. Examples of outputs from this collaboration include the following:

  1. Kolev M, West E, Kunz N, Chauss D, Moseman E, Rahman J, Freiwald T, Balmer M, Loetscher J, Dimeloe S, Rosser E, Wedderburn L, Mayer-Barber K, Bohrer A, Lavender P, Cope A, Wang L, Kaplan M, Moutsopoulos N, McGavern D, Holland S, Hess C, Kazemian M,  Afzali B, Kemper C, “Diapedesis-induced integrin signaling via LFA-1 facilitates tissue immunity by inducing intrinsic complement C3 expression in immune cells”. Immunity 2020; 52(3): 513-527. (Immunity Link)
  2. Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen Y-C, Becker P, Boardman D, Constantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun H-W, Shih H-Y, Cousins D, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B. Retinoic acid-regulated CD161+ Tregs support wound repair in intestinal mucosa. Nature Immunology 2018; 19: 1403-1414. (Nature Immunology Link)
  3. McGregor R, Chauss D, Freiwald T, Yan B, Wang L, Nova-Lamperti E, Zhang Z, Teague H, West EE, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz D, Portilla D, John S, Lavender P, Lionakis MS, Mehta NN, Kemper C, Cooper N, Lombardi G, Laurence A, Kazemian M*, Afzali B*. An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19. bioRxiv Under Review (bioRxiv link).
  4. Yan B, Freiwald T, Chauss D, Wang L, West E, Bibby J, Olson M, Kordasti S, Portilla D, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. SARS-CoV2 drives JAK1/2-dependent local and systemic complement hyper-activation. Res Sq. Under Review (Res Sq link).
  5. Chakravorty S, Yan B, Wang C, Majumder J, Wang L, Olson M, Canaria A, Chauss D, Chopra G, Zhao B, Afzali B, M. Kazemian, Integrated pan-cancer map of EBV-associated neoplasms reveals functional host-virus interactions, Cancer Research, 1;79(23):6010-6023, 2019. (Cancer Research Link)

The successful candidate will be based either in the Immunoregulation Section of the Kidney Diseases Branch of NIDDK at NIH (Immunoregulation Section) or the Kazemian lab at Purdue University (Kazemian lab). They will leverage bulk-level and single cell high throughout methodologies (RNA-seq, ChIP-seq, CUT&RUN, CUT&Tag, ATAC-seq, RNAi screening etc) to study basic and translational immune cell immunoregulation. Candidates are expected to be independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques. Experience of immunological mouse models is highly desirable for this post.

Position(s) Location: Bethesda NIH campus, Maryland; and Purdue University, West Lafayette, Indiana

Qualifications:

Being able to perform high-throughput sequencing library preparation is highly desirable. The following are essential criteria:

  • PhD in molecular and cell biology, immunology or related fields;
  • Experience with mouse models;
  • Experience in mammalian cell isolation, transfection techniques, cell culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and transcriptional regulation;
  • Strong oral and written communication skills;
  • Excellent organizational and record keeping skills with high attention to detail;
  • Ability to work independently as well as collaboratively with others;
  • Personal and professional integrity;
  • Flexibility in work scheduling;

To Apply:

Please submit your CV and cover letter outlining your interests and accomplishments, plus three letters from referees, to behdad.afzali@nih.gov. Please indicate in your cover letter why you are interested in joining our group. Applications will only be considered once all three references have been submitted. Applicants not meeting the essential criteria will not be considered.

 

Purdue University is an EOE / AA employer.

The NIH is dedicated to building a diverse community in its training and employment programs. All individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.