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Gene Expression and Scleroderma

National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD and surrounding area

Position Description:

A postdoctoral fellowship position is available in the Scleroderma Genomics and Health Disparities Unit (SGHDU) at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH. The position is based in Bethesda, Maryland.

The Gourh lab is focused on understanding the genetics of scleroderma, a rare autoimmune disease utilizing next generation sequencing, SNP genotyping technologies, along with molecular and biochemical approaches to functionally elucidate the role of disease-causing variants. The successful candidate will be expected to be skilled in the full range of molecular and cell biology and immunology techniques, including, tissue culture, transfection, flow cytometry, and CRISPR-Cas9. We utilize CRISPR/Cas9 edited induced pluripotent stem cells and primary cell lines as well as RNA-Seq, ATAC-Seq, ChIP-Seq, CUT&RUN, single cell technologies and bioinformatics to study how variants in regulatory elements affects transcription factor binding to regulate gene expression.

For additional information, please visit: https://www.niams.nih.gov/labs/scleroderma-genomics-and-health-disparities-lap

Qualifications:

  • PhD degree in biological sciences with less than 3 years of postdoctoral experience.
  • Experience in production of induced pluripotent stem cells (iPSCs) and differentiation into various cell types
  • Experience with CRISPR gene editing
  • Previous experience in molecular biology, cell biology, biochemistry, immunology will be preferred
  • Self-motivated with excellent communication and writing skills

To Apply:

Interested candidates should submit a short statement of their research goals, current curriculum vitae, publication record, and names and contact information of three referees to Dr Pravitt Gourh at pravitt.gourh@nih.gov

 

This post will be available until June 22, 2021 or until filled.

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