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Motor Protein Function in Intestinal Organoids

National Heart, Lung, and Blood Institute, Bethesda, MD and surrounding area

Position Description:

A fully-funded postdoctoral position is available for a highly-motivated scientist who would like to use genetic, cell biological, and advanced imaging approaches to define the roles played by actin-based motor proteins in epithelial barrier function and apoptotic cell extrusion using intestinal organoids as a model system. Intestinal organoids provide a very physiological context in which to study these phenomena as they retain normal epithelial organization, dynamics and polarity in the form of a three dimensional, regenerative, stem cell-driven tissue model. Moreover, they are amenable to detailed structure: function analyses using CRISPR-mediated gene editing, super-resolution microscopy, and other advanced tools. Organoids made from mouse knockouts for myosin 2C, myosin 18A, and myosin 10 with interesting preliminary phenotypes await further characterization. The lab and institute offer a fantastic, highly-collaborative training environment for budding young scientists, with cutting-edge resources, microscopes, and expertise, as well as rigorous mentoring and generous support for trainees.

Qualifications:

Ph.D. and/or MD. degree (or anticipate receiving their degree in the near future). Individuals with less than three years of postdoctoral experience are preferred. Prior training in cell biology, molecular biology, biochemistry, or imaging is preferred but not essential. Individuals with a background in biophysics who would like to learn cell biology are also encouraged to apply.

To Apply:

Interested individuals should send their CV, a brief description of their background, interests and career goals, and the names of three people who can be contacted for reference letters to John A. Hammer, Cell and Developmental Biology Center, Building 50, Room 2523, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892-8017 (hammerj@nhlbi.nih.gov).

 

This post will be available until July 4, 2021 or until filled.

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