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Human Monoclonal Antibodies Against Plasmodium falciparum

National Institute of Allergy and Infectious Diseases, Bethesda, MD and surrounding area

Position Description: 

The Antibody Biology Unit at the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, (https://www.niaid.nih.gov/research/joshua-tan-phd) is seeking a highly motivated postdoctoral researcher to lead a project on the characterization of human monoclonal antibodies against blood-stage Plasmodium falciparum.

The goal of the Antibody Biology Unit is to use cutting-edge techniques to decipher the antibody response to major pathogens, both to further our knowledge of basic B cell biology and to make translational advances that impact global health. Ongoing work includes a study on bispecific antibodies against SARS-CoV-2 (https://www.biorxiv.org/content/10.1101/2021.04.01.437942v1)  and a partnership with the Bill & Melinda Gates Foundation to identify potent monoclonal antibodies against pre-erythrocytic stages of P. falciparum. The project that is available will involve the isolation and characterization of human antibodies against blood-stage P. falciparum, as well as identification of target antigens as novel vaccine candidates. If a suitable antibody is identified, it can be tested for the ability to prevent malaria in a clinical trial in a malaria-endemic region through intramural collaborations. Candidates will have access to unique cohort samples, high-throughput devices for screening single B cells, and an array of tools and assays to characterize human antibodies, including the Berkeley Lights Beacon (optofluidics), Intellicyt iQue Screener (high-throughput flow cytometer) and Carterra LSA (high-throughput SPR). This position is ideal for a candidate who is interested in a project with both basic and translational features that aims to discover new targets and investigate prophylactics for use in malaria.

Qualifications:

Applicants must have:
  1. A recent PhD (<3 years or current PhD students finishing in 2021)
  2. A solid background in immunology
  3. Ability to work in a team
  4. Excellent organizational, written and communication skills
  5. First-author publication(s) in peer-reviewed journals
  6. Research experience
    • Blood stage P. falciparum culture
    • Cell culture, PCR, ELISA, Western blot, flow cytometry
    • Preferred – experience with computational analysis of antibody sequences including VH/VL gene usage and lineage

To Apply:

Please submit a cover letter, CV and contact information for three references to:

Joshua Tan, Chief, Antibody Biology Unit at tanj4@nih.gov

 

This post will be available until July 19, 2021 or until filled.

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