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Human Monoclonal Antibodies Against Mycobacterium tuberculosis

National Institute of Allergy and Infectious Diseases, Bethesda, MD and surrounding area

Position Description:

The Antibody Biology Unit at the Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, (https://www.niaid.nih.gov/research/joshua-tan-phd) is seeking a highly motivated postdoctoral researcher to lead a project on the characterization of human monoclonal antibodies against Mycobacterium tuberculosis. The goal of the Antibody Biology Unit is to use cutting-edge techniques to decipher the antibody response to major pathogens, both to further our knowledge of basic B cell biology and to make translational advances that impact global health. Ongoing work includes a study on bispecific antibodies against SARS-CoV-2 (https://www.biorxiv.org/content/10.1101/2021.04.01.437942v1) and a partnership with the Bill & Melinda Gates Foundation to identify potent monoclonal antibodies against pre-erythrocytic stages of P. falciparum.

While the role of T cells in immunity against M. tuberculosis has been well-established, evidence is building that antibodies also play a protective role in TB. However, the most relevant targets and mechanisms of antibody-mediated immunity remain elusive. This project will involve the isolation and characterization of human antibodies against M. tuberculosis, as well as identification of target antigens as novel vaccine candidates. Candidates will have access to samples from TB-infected patients, high-throughput devices for screening single B cells, and an array of tools and assays to characterize human antibodies, including the Berkeley Lights Beacon (optofluidics), Intellicyt iQue Screener (high-throughput flow cytometer) and Carterra LSA (high-throughput SPR). This position is ideal for a candidate who has a solid background in TB research and is interested in a project with both basic and translational features that aims to discover new targets in TB.

Qualifications:

Applicants must have:
  1. A recent PhD (<3 years or current PhD students finishing in 2021)
  2. A solid background in immunology
  3. Ability to work in a team
  4. Excellent organizational, written and communication skills
  5. First-author publication(s) in peer-reviewed journals
  6. Research experience
    • Work with M. tuberculosis, including in BSL-3
    • Cell culture, PCR, ELISA, Western blot, flow cytometry
    • Preferred – experience with computational analysis of antibody sequences including VH/VL gene usage and lineage

To Apply:

Please submit a CV, cover letter, and contact information for three references to:

Joshua Tan, Chief, Antibody Biology Unit at tanj4@nih.gov

 

This post will be available until July 19, 2021 or until filled.

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