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NADPH Oxidase Mediated Signaling Mechanisms in Cancer

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

The Oxidative Signaling and Molecular Therapeutics Group (OSMTG), Developmental Therapeutics Branch (DTB), National Cancer Institute (NCI), led by Dr. James H Doroshow is inviting qualified applications for a postdoctoral research position in the area of cancer therapeutics. The candidate will perform basic research on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mediated signaling mechanisms in cancer therapeutics. The candidate will investigate the role of reactive oxygen species (ROS) in the regulation of gene expression, signal transduction, and proliferation in human tumor cell systems, as well as clinical samples.  This research effort also focuses on the development of small molecule inhibitors targeting ROS generating NADPH oxidases. We are seeking a highly motivated individual with demonstrated scientific productivity to join the laboratory.  Experience in eukaryotic molecular pharmacology and signal transduction is required; expertise in cell- and in vivo-based molecular pharmacodynamics and free radical biology is also desirable.

Additional details of the laboratory can be accessed at:


The ideal candidate will have a PhD degree in Biochemistry, Molecular/Tumor Biology, or related disciplines and preferably prior experience in Molecular Biology and Biochemistry. Communication skills and the ability to collect, analyze, compile, and communicate complex scientific data both verbally and in writing is an essential prerequisite for this position.  Salary is commensurate with research experience and accomplishments. 

This position is subject to a background investigation.

To Apply:

Please submit your resume/CV and supporting documentation to:  Monika Sarna, NCI Administrative Officer, Office of the Director, Division of Cancer Treatment and Diagnosis, at:


This post will be available until July 20, 2021 or until filled.

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DHHS and NIH are Equal Opportunity Employers.