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Regulation of G Protein Signaling

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD and surrounding area

Position Description:

A Postdoctoral Fellow position is available immediately in the Endocrine Signaling & Oncogenesis Section of the Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases to study the basic science of regulator of G protein signaling (RGS) protein function downstream of Gi/o-coupled receptors in the brain and sensory neurons.  Studies center on the physiology and pathophysiology of the protein complex involving G protein β5, R7BP, and the R7-RGS subfamily of RGS proteins expressed in central and peripheral neurons. We are currently studying the role of the Gβ5 complex in somatosensation, and the neuropathologic consequences of GNB5 heterozygosity (GNB5 encodes Gβ5).
(Homozygous loss of function of GNB5 in humans leads to severe developmental delay with intellectual disability; see OMIM entries here and here.)
Tentative starting date: flexible
The salary and benefits follow NIH guidelines commensurate with experience.


Applicants must have a Ph.D. and/or M.D. degree with fewer than five years of postdoctoral experience.  Our interdisciplinary approach utilizes a variety of techniques. Candidates with an interest in neuroscience and documented experience in one or more of the following areas are strongly encouraged to apply:
  • Biochemistry – recombinant protein purification, affinity purification, FPLC
  • Neuroscience- neurodegenerative disease models, somatosensory signaling, primary neuronal cell culture, calcium imaging with fluorescent indicators
  • Pharmacology- signal transduction, chemogenetics
  • Transgenic, knockout, and conditional knockout mouse models
  • Mouse brain histology- RNAscope, in situ hybridization, immunohistochemistry, transparent brain imaging
  • Molecular biology- CRISPR gene editing, iPSC generation 

To Apply:

Applicants should send a brief statement of research interests, their curriculum vitae, and the names and contact information of three (3) references to William F. Simonds (
For more information: please contact William F. Simonds, MD, Chief, Endocrine Signaling & Oncogenesis Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Building 10, Room 8C-101, Bethesda, MD 20892, USA, Tel: (301) 496-9299, E-mail:,
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