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Molecular Biology of the Developing and Regenerating Olfactory System

National Institute of Neurological Disorders and Stroke, Bethesda, MD and surrounding area

Position Description:

The Molecular Neurobiology Section (MNS) at NINDS, under the direction of Dr. John Ngai, is currently seeking to fill one or two postdoc positions to study the development and circuitry of the olfactory system and regeneration of the injured olfactory epithelium. The specific focus of this position is to oversee studies using the mouse peripheral olfactory system as a primary model to better understand the genetic, epigenetic and cell signaling pathways underlying neural development and adult stem cell-mediated regeneration. These studies will use a combination of approaches including single-cell transcriptomic and epigenomic analyses, mouse transgenic and other genetic approaches, viral transduction, immunohistochemistry, multiplexed RNA in situ hybridization, and confocal and other advanced light microscopy techniques. Our long-term goal is to elucidate the molecular determinants regulating the progression of cells in a developmental or regenerating pathway during the construction or repair of neural circuits.
 

Qualifications:

A Ph.D. degree (or equivalent) in Molecular, Cellular, and/or Developmental Biology, Genomics, Computational Biology, or related field, experience supervising trainees in laboratory research, and experience in a combination of the following interdisciplinary techniques:
  •  Genomics-based analysis of a biological system
  • Next-generation sequencing (library construction and/or data analysis)
  • Mouse genetics
  • Biochemistry of the neuron (immunoprecipitation of membrane and/or synaptic proteins, mass spectrometry)
  • Histology (especially fluorescence in situ hybridization) and confocal microscopy
  • Viral neuronal circuit tracing
Strong communication and organization skills and an ability to work independently are imperative. The NIH is dedicated to building a diverse community in its training and employment programs.
 

To Apply:

Interested applicants should send an email or cover letter describing their research experience and interests, a CV, and contact information for 3 references (email, title, and phone number) to:
 
Whitney Heavner, Ph.D.
Staff Scientist, John Ngai Lab
 
 

The NIH and HHS are dedicated to building a diverse community in their training and employment programs.