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Analysis and Exploitation of Tumor-Associated Vasculature

National Cancer Institute, Frederick, MD

Position Description:

Tumor-associated stromal cells play an essential role in promoting tumor growth.  Tumor-infiltrating blood vessels, for example, sustain solid tumor growth by providing critical nutrients and growth factors.  We seek a highly motivated, creative and bright individual, to work on a project that involves both basic and translational studies on tumor angiogenesis.  The laboratory focuses on the characterization and exploitation of cell surface molecules that are elevated in the tumor associated stroma, especially the tumor vasculature.  Studies to explore the function of tumor-associated stromal markers and their downstream signaling pathways involve the use of a variety of genetically engineered mouse models.  Another area of study involves the development of novel diagnostics and therapeutics for cancer.  The laboratory is particularly interested in developing, producing and characterizing new antibodies and antibody-drug conjugates (ADCs) against tumor stromal markers for preclinical testing in mouse tumor models.  The tumor angiogenesis lab is located at the National Cancer Institute in Frederick with access to state-of-the-art facilities for antibody engineering, genomic analysis, pathology, and small animal imaging, among others.


The candidate should have extensive experience in the area of molecular biology and biochemistry and evidence of excellent training and productivity. Candidates are expected to be nearing completion of a Ph.D. or M.D./Ph.D. in biomedical research with a strong publication record and expertise in molecular and cell biological techniques.  Motivated candidates who are interested in innovative, high-impact research are encouraged to apply. A background in molecular biology, cancer biology or immunotherapy is preferred. Experience with antibodies or ADCs is a big plus.

To Apply:

Interested applicants should send their curriculum vitae, a brief description of their research interests and career goals, and contact information for three references to Dr. Brad St. Croix by email to
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.