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Development and Regulation of the GnRH Neuroendocrine System

National Institute of Neurological Disorders and Stroke, Bethesda, MD and surrounding area

Position Description:

Cellular, Developmental or Molecular postdoctoral fellow positions for Intramural Training Awards (< 2 years from degree) in the Cellular and Developmental Neurobiology Section (CDNS,  https://dir.ninds.nih.gov/Faculty/Profile/susan-wray.html). Lab focuses on mechanisms directing development and regulation of the GnRH neuroendocrine cells which arise in olfactory regions and migrate into the brain, where they control reproductive function.
 

Qualifications:

Developmental research addresses Cell lineage, Neuronal Migration, Axonal Targeting, Craniofacial development and Understanding mutations identified in patients with Kallmann Syndrome. Candidates with experience in mouse development, molecular and imaging techniques preferred.
 
To understand the mechanisms underlying GnRH neuronal activity, primary GnRH neurons in explants, slice cultures and whole animals are assayed to study the molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) and correlate activity with secretion. Candidates with experience in calcium imaging or electrophysiology, molecular biology and mouse anatomy preferred.
 

To Apply:

Applicants should email Dr. Susan Wray (wrays@ninds.nih.gov) an updated C.V., cover letter and names of references. Applications will be accepted until the position is filled.
 

Recent publications:

Shan, Y. Farmer, SM, Wray, S. Drebrin Regulates Cytoskeleton Dynamics in Migrating Neurons through Interaction with CXCR4. PNAS, 2021.
Constantin S, Reynolds, D. Oh, A, Pizano K, Wray S. Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment. PNAS, 2021.
 
 
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