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Gene Regulatory Mechanisms in Retinal Pigment Epithelium

National Eye Institute, Bethesda, MD and surrounding area

Position Description:

A post-doctoral position is available immediately in the lab of Dr. T. Michael Redmond, Laboratory of Retinal Cell & Molecular Biology (LRCMB), National Eye Institute (NEI) to study mechanisms of gene regulation in the retinal pigment epithelium (RPE) of the outer retina.

The Redmond lab studies several aspects of retina/RPE biochemistry. Many blinding diseases (inherited and age-related) involve derangement of key RPE processes. Our overall goal is to identify novel molecular mechanisms to better understand the functional role of these processes, identifying potential therapeutic targets where possible. Among these, we wish to understand how RPE genes are regulated by non-coding RNAs, and especially by long non-coding RNAs.

Additionally, the lab has developed a collaborative project leveraging the skills of its members, in the RNA biology and translation of SARS-CoV-2 spike (S) protein, and the receptors through which S protein interacts with ocular cells.

In addition to LRCMB research resources in biochemistry, molecular biology, cell biology, etc., the successful fellow will have access to a wide range of NEI core facilities including biological imaging, genetic engineering, phenotyping, and bioinformatics, as well as broader NIH facilities.

The successful applicant will be expected to lead individual projects as well contribute to collaborative research efforts in the laboratory. Our group interacts with several other NEI and NIH labs in a variety of areas, and the successful applicant will have opportunities to collaborate with these labs and groups, as well as extramurally.

Qualifications:

  • Candidates must hold a Ph.D., M.D./Ph.D. or equivalent doctoral degree in a cognate field, within five years of degree being awarded;
  • Must have first authorship on one or more peer-reviewed publications;
  • Have strong training in molecular biology/biochemistry/omics;
  • Prior experience in genomics/transcriptomics and non-coding RNAs will be an added advantage;
  • Have excellent writing and communications skills;
  • Candidates must be highly motivated and keen to further develop technical expertise and career-enhancing skills;
  • The ability to work as part of a cohesive group is important as we are a highly collaborative lab.

To Apply: 

Please email (i) your CV, (ii) a cover letter detailing research interest, experience, and career goals, and (iii) names and contact info for 3 professional references to T. Michael Redmond, Ph.D. at redmondd@nei.nih.gov.

 

This post will be available until December 1, 2021 or until filled.

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