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Immunology and mechanobiology - Two Photon Microscopy/Confocal Microscopy

National Center for Complementary and Integrative Health, Bethesda, MD and surrounding area

Position Description:

Dr. Helene Langevin, Director of the NCCIH, National Center for Complementary and Integrative Health NIH, Bethesda, MD and Principal investigator at the Connective tissue Section NIDCR-National Institute for Dental and Craniofacial Research, is recruiting a postdoctoral researcher in the field of Immunology and mechanobiology with expertise in Two photon microscopy and/or confocal microscopy

The laboratory is known for its major contributions studding non-pharmacological approaches, such as stretching, to mitigate inflammation and prevent tissue damage. We have developed several animal models to study the impact of stretching on inflammation resolution and to understand how mechanical factors within the stroma, can influence the growth of tumors. Current projects include:  1) Exploring the impact of stretching on key components of the immune response named NK cells, Treg, effector cytokines, inhibitory receptors (PD1, LAG3, TIM3) and their possible role reducing inflammation, tumor growth and metastasis; using: multiparameter flow cytometry, transcriptomic and  single cell RNA seq and biochemical analysis. Use dual photon second harmonic imaging to study tumor collagen structure and extracellular matrix, measure parameters such as collagen length, orientation and straightened. 3) Track immune cells within the tumor microenvironment. 4)The lab also uses an in vitro model where fibroblasts seeded in collagen gels are stretched and the impact of the mechanical force is analyzed by microscopy, gene expression and biochemical analysis.

Principal Duties and Responsibilities:

Developing two-photon microscopy technology for measuring tumor stroma architecture and tracking immune cell populations within the tumor microenvironment. In collaboration with the Principal Investigator, this role will participate in the planning of independent research, will analyze and interpret data, will publish results, will represent the Lab at conferences and meetings, and may develop new theories and methodologies.


The ideal candidate will be innovative, interactive, have a strong background in immunology, molecular biology and two photon microscopy and/or confocal microscopy. The candidate must have received a Ph.D. and/or an M.D. degree. The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.   

To Apply:

To apply, email your curriculum vitae and names with contact information of three references to: Dr. Helene Langevin Chief (, Lab of Connective Tissue section and Director, NCCIH. Lab is located at NIDCR Bldg. 30, Rm 532., NIH Bethesda, MD 20892-1674.


This post will be available until December 3, 2021 or until filled.

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