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Immune Dysregulation in Aging to Device Therapeutics for Aging-Associated Diseases

National Institute on Aging, Baltimore, MD

Position Description:

The mechanism of immune dysregulation in aging and its consequence in aging-associated diseases remain poorly understood. The Immunoregulation section, the National Institute on Aging, is seeking an ambitious and highly motivated person to lead studies in elucidating dysregulation of adaptive immune cells in cancer or Alzheimer’s disease and the role of gut microbiome change in aging to devise simpler therapeutics for elderly people.
 
The work will involve modeling studies in mice and use of latest tools, such as immune cell and microbiome sequencing, scRNA-seq, ATAC-seq,  flow cytometric and immune fluorescent staining of murine and human tissues, and generation of novel recombinant proteins.  For information about projects in the lab, please see our recent papers: B cells in manifestation of Alzheimer’s disease (Ki et al., Nature Communications, 2021); regulatory B cells in cancer (Ragonnaud  et al., Cancer Research, 2019); the role of A. muciniphila in aging immune dysregulation and insulin resistance (Bodogai et al., Science Transl. Med., 2018). The laboratory is located in Baltimore, MD. For information about the laboratory, please visit https://irp.nih.gov/pi/arya-biragyn. About life in Baltimore, please visit https://www.southernmanagement.com/blog/what-is-it-like-to-live-in-baltimore-maryland
 

Qualifications:

Applicants must have a PhD. and /or M.D. degree (or anticipate receiving their degree in the near future) with less than five years of postdoctoral experience. Applicants should have the ability to carry out independent research, a strong interest in interdisciplinary approaches and have published articles in peer-reviewed journals. Training in molecular biology, immunology, biochemistry, neuroscience and bioinformatics is preferred. NIH offers excellent salary and health care packages to its trainees and has consistently been ranked among the best places to work for postdoctoral fellows.
 

To Apply:

To apply, please submit letter of interest, curriculum vitae, and references to: Arya Biragyn, Ph.D., Chief, Immunoregulation section, NIH/NIA/IRP, Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224 USA. Office phone: 410-558-8680, or e-mail: biragyna@mail.nih.gov
 
 
This position is subject to a background investigation. DHHS, NIH and NCI are Equal Opportunity Employers. The NIH is dedicated to building a diverse community in its training and employment programs.