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Role of Protein Quality Control in Neurodegenerative Diseases

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD and surrounding area

Position Description:

A postdoctoral position is available in the Laboratory of Molecular Biology at the National Institute of Diabetes, Digestive, & Kidney diseases (NIDDK) in National Institutes of Health. We are looking for a highly motivated postdoctoral fellow to lead an independent research project aimed at understanding the various protein quality control mechanisms in mammalian cells.

The ongoing projects include unconventional secretion of misfolded proteins (Nat. Cell Biol. 2016 18(7):765-76; BioRxiv, 2021, doi:,  the processing of extracellular protein aggregates (PNAS, 2020 117(20) 10865; Nature Communications, 2021 12(1)), and translocon-associated quality control (Cell Research, 2020 30(1) 5-20). The fellow is expected to dissect how eukaryotic cells cope with various disease-associated toxic proteins such as Tau, Abeta and alpha-Synuclein using a combination of live cell confocal microscopy, genetic screens, biochemical purification and reconstitution, and structure-based functional assays.

The NIH offers competitive salary and an outstanding research environment with many opportunities to collaborate.


A Ph.D. degree with a strong publication record in biochemistry and/or structural biology, or neurobiology.

To Apply:

Interested candidates should send CV with the names of three references and a Statement of Research Interest to Dr. Yihong Ye (


NIH is an Equal Opportunity Employer and is dedicated to building a diverse community in its training and employment programs.