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Antibody Discovery and Characterization

National Center for Advancing Translational Sciences, Bethesda, MD and surrounding area

Position Description:

NCATS, a major research component of NIH, is seeking applications from exceptional candidates to hold a postdoctoral position in antibody discovery and characterization in the Early Translational Branch (ETB) of its Division of Preclinical Innovation, located in Rockville, Maryland. Part of the ETB’s mission is to develop new therapeutic approaches in areas of medical need. The branch partners with external collaborators who specialize in specific disorders, creating a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, automation engineering, bioinformatics and various -omics technologies.
The selected postdoctoral fellow will work under the mentorship of a biology team leader in an interactive laboratory environment and be exposed to cutting-edge high-throughput screening, assay biology, bioinformatics, medicinal chemistry and disease-relevant biological models. They will implement antibody discovery technologies (including phage display), directed evolution, and related technologies to produce and characterize antibodies relevant to diseases and conditions related to pain, addiction and overdose, and other public health emergencies, such as the SARS-CoV-2 pandemic. The incumbent will apply cutting-edge cell biology and bioassay technologies for the development of disease-relevant antibody selection and screening assays and will be involved in all aspects of the implementation, including assay design, assay development and optimization, antibody screening, protein engineering, data analysis and mechanism-of-action studies.
Core Responsibilities
The selected candidate must be able to work independently under team supervision. The incumbent will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They will draft technical reports and manuscripts and will present work internally and to external collaborators as needed.


Applicants should have (or expect to receive) a Ph.D. and have less than three years of postdoctoral experience in cell biology, molecular biology, pharmacology or a related discipline. Experience with antibody phage display technologies — including panning, ELISA, and protein purification — and an understanding of antibody domain architecture are highly desirable. The candidate should be an independent thinker, a team player, and able to work in a very interactive, fast-paced environment. Applicants must be eligible to work in the United States for any employer.
Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; health insurance benefits are available. The fellow also may take part in Foundation for Advanced Education in the Sciences courses at NIH.

To Apply:

Please submit, in PDF format, a cover letter that includes a research summary and describes your interest in the position, a current curriculum vitae with a complete bibliography, and the names of and contact information for three references to (link sends e-mail). Selected applicants will be required to submit letters of reference to complete the hiring process.
The review of applications will begin immediately and will continue until the position is filled. Learn more about intramural research at NCATS.

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