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Protein Chemistry & Molecular Biology

National Cancer Institute, Frederick, MD

Position Description:

The Molecular Targets Program (MTP) of the National Cancer Institute’s Center for Cancer Research (NCI’s CCR) has postdoctoral positions available in its Protein Chemistry and Molecular Biology Section (PCMBS). The PCMBS uses its expertise in protein chemistry, biophysics, enzymology, molecular biology and screening to adapt CCR basic science laboratory findings into high throughput, cell-free screens for the interrogation of pure compound and pre-fractionated natural product libraries. In addition, we use these same skills to discover and characterize novel bioactive proteins from natural product extracts that increase our knowledge of protein structure and function, address diseases and molecular targets of interest, and potentially lead to clinical development.
The position is for a researcher with published expertise in enzyme kinetics and in-vitro inhibitor/activator mechanism of action studies to develop and implement high-throughput assays for the discovery of biologically active synthetic and natural product-derived compounds. Applicants should highlight their experience in relevant methods of in-vitro enzymology in their introductory email. Previous experience in high throughput screening or natural products discovery is not required but will be prioritized in candidate evaluation.



Candidates must have a Ph.D. in biochemistry, cell/molecular biology, pharmacognosy or a related discipline from an accredited research institution within the last three years. The fellowship duration is for a maximum of 5 years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. The fellowship stipend starts at a flat rare per annum and is determined based on qualifications and years of relevant experience. Applicants should submit a cover letter, CV with bibliography, and three letters of reference to

To Apply:

More information about the Molecular Targets Program is available here:
This position is subject to a background investigation.
The NIH is dedicated to building a diverse community in its training and employment programs. DHHS, NIH, and NCI are Equal Opportunity Employers