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Structural Bioinformatics and Computational Biology

National Library of Medicine, Bethesda, MD and surrounding area

Position Description:

The Laboratory of Structural Bioinformatics at the National Library of Medicine, located on the main National Institutes of Health (NIH) campus in Bethesda, Maryland, is opening a postdoctoral position in the areas of computational biology and structural bioinformatics.

This position would involve developing computational methods that characterize fold-switching proteins, which remodel their secondary structures and change their functions in response to cellular stimuli (https://www.nature.com/articles/s41467-022-31532-9, https://www.pnas.org/content/115/23/5968.short). Depending on the candidate’s background and interests, several projects are possible. Specific projects would involve predicting fold switchers from their genomic sequences, design of fold-switching sequences, and/or developing interactive websites and databases for future characterization of fold-switching proteins.

Qualifications:

The applicant should be a creative, motivated individual interested in developing cutting-edge computational methods that lay the foundation of an up-and-coming area of protein research.

Applicants who meet the following requirements will be considered for the position:
  • PhD in bioinformatics, computational biology, biophysics, computer science, or a closely related field. Applicants close to finishing a PhD in one of these areas will also be considered.
  • Strong proficiency in python
  • LINUX proficiency
  • In-depth understanding of protein structure and protein biochemistry
  • Strong oral and written communication skills
Prior experience in at least one of the following computational areas is required:
  • Modeling and prediction of protein structure/function
  • Deep learning applied to proteins
  • Design and implementation of interactive websites related to protein structure
  • Computational protein design

Salary will depend on qualifications and is determined based on current NIH pay scale.

To Apply:

Interested applicants should submit their curriculum vitae (CV), a statement of research interests, and contact information for three references via email to Lauren Porter, PhD at porterll@nih.gov.

Posted UntiL Deadline: October 14, 2022

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