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Immunotherapy in Sarcomas

Center for Cancer Research, National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

Osteosarcoma and other sarcomas are resistant to immunotherapies because they are generally “cold” tumors. Our recent studies have identified a surface protein that regulates osteosarcoma cell-host interaction. Preliminary data show that genetic deletion of this protein in osteosarcoma cells enhances infiltration of anti-tumor immune cells in the tumor and subsequent tumor reduction. However, the underlying mechanism is unknown. The successful candidate will investigate the mechanism using single-cell sequencing and high-throughput flow cytometry at the Laboratory of Cancer Biology and Genetics, NCI, NIH (Bethesda campus). The overarching goal is to identify new strategies to increase the efficacy of immunotherapy in osteosarcoma and other sarcomas.


Requirements include a strong background in cell biology, tumor biology, and immunology. Good communication skills are necessary, and experiences in immunology, tumor (particularly sarcomas), and/or mouse models are a plus. Successful candidates must be expected to obtain a Ph.D. and/or M.D. degree within three months or have less than one year of postdoctoral experience at the time of application.

To Apply:

If interested, please send your CV and three references to:

Jing Huang, Ph.D.
Senior Investigator
Head, Cancer and Stem Cell Epigenetics
Laboratory of Cancer Biology and Genetics
National Cancer Institute
Building 37, Room 3140A
37 Convent Drive
Bethesda, MD 20852
Phone: 240-760-6796

Posted Until: October 22, 2022

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