Skip to Content

RNA and Cancer Biology

National Cancer Institute, Frederick, MD

Position Description:

The Eukaryotic Transcriptional Regulation Section in the Mouse Cancer Genetics Program at NCI-Frederick seeks a highly motivated postdoctoral researcher to participate in a project exploring mechanisms that control cellular responses to oncogenic RAS signaling. The project focuses on the novel role of 3’UTRs in regulating phosphorylation/activation of the encoded proteins by oncogenic kinases such as ERK1/2 and CK2. The mechanism involves mRNA partitioning, in part through localized, 3’UTR-mediated mRNA decay adjacent to perinuclear kinases in tumor cells. Our research is highly interdisciplinary and intersects the fields of RNA biology, signaling and cancer biology. Candidates should have a rigorous background in molecular/cellular biology, with experience in RNA biology strongly preferred. Talented individuals who wish to pursue an independent research track will have the opportunity to develop their own projects toward the end of their training period.

Detailed information on the lab’s current research can be found at: https://ccr.cancer.gov/staff-directory/peter-f-johnson

For a list of lab publications, please click on the link below:
https://pubmed.ncbi.nlm.nih.gov/?term=Johnson+PF&sort=date

Pre-print manuscripts:
Salotti, J. et al.: 3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPb phosphorylation/activation to suppress senescence in tumor cells. https://doi.org/10.1101/2022.03.29.486281
Hu, L. et al.: 3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity. https://doi.org/10.1101/2022.04.04.487038
Basu, S. et al.: CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS mutant cancers. https://doi.org/10.1101/2022.04.05.487175

Qualifications:

Good oral and written communication skills are required. Applicants must have a Ph.D. and/or M.D. or equivalent degree and should have less than one year of postdoctoral experience. The position is available immediately.

To Apply:

The Mouse Cancer Genetics Program offers a challenging, stimulating and collaborative research environment and training opportunities to postdoctoral fellows. Applications, sent by e-mail to: johnsope@mail.nih.gov, should consist of a cover letter describing research experience and interests, curriculum vitae, bibliography, and contact information for three references.

The NIH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.