Investigating cell dynamics with live-cell biosensors

A postdoctoral position is available in the lab of Dr. Steven Cappell in the Laboratory of Cancer Biology and Genetics, National Cancer Institute. Dr. Cappell is interested in understanding how signal transduction networks are wired to form logical circuits and to understand how these networks function in space and time to regulate diverse aspects of human physiology. Our approach is to combine live-cell imaging of fluorescent biosensors in single cells with genetic and pharmacological perturbations to identify regulatory mechanisms of signal transduction pathways. In particular, we are interested in understanding how cells make the decision to enter the cell cycle and proliferate and how this decision is perturbed in cancer. The postdoctoral fellow will investigate cell cycle dynamics in both normal and cancer cells using cutting edge imaging and analysis tools. An additional goal of this project will be combine live-cell imaging pipelines with single-cell RNA sequencing.

We seek a talented, curious, and highly motivated postdoctoral fellow with an interest in cell biology, genomics, signal transduction, or live-cell imaging. Ability to implement customized algorithms (MATLAB, R, python, etc) is highly desirable. Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab. This position is subject to a background investigation.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.