Postdoctoral Fellow

Our laboratory investigates innovative approaches that improve the safety, durability, and accessibility of stem cell gene therapy by combining gene engineering with targeted conditioning and selective expansion of edited hematopoietic stem cells.

These studies integrate human hematopoietic stem cell biology with clinically relevant mouse and nonhuman primate transplantation models. As such, our current research areas include:

• Antibody-based conditioning strategies targeting hematopoietic stem cells
• Engineering hematopoietic stem cells for resistance to targeted conditioning agents
• In vivo selection and expansion of genetically modified stem cells
• Lentiviral gene addition and genome editing approaches for hemoglobinopathies
• Evaluation of hematopoietic reconstitution, lineage output, and long-term stem cell function following transplantation
• Development of chemotherapy-free transplantation strategies with improved safety and efficacy
• Translation of novel conditioning and transplantation approaches into large animal models

Again, our laboratory emphasizes rigorous mechanistic research while pursuing translational studies designed to advance safer and more effective stem cell therapies for patients with inherited blood disorders.

Applicants should have a Ph.D., M.D., or equivalent doctoral degree obtained within the past 5 years, or otherwise be expected to receive their degree within the next 6 months, in molecular biology, genetics, stem cell biology, biomedical engineering, immunology, and/or a related field.

Experience in hematopoietic stem cell isolation and culture, stem cell transplantation, Flow cytometry, animal handling, molecular biology, cell engineering, Lentiviral vectors and/or genome editing technologies is highly-desirable but not required.

Prospective candidates will join a collaborative and multidisciplinary research environment with extensive opportunities to interact with investigators at NIH and at leading academic and biotechnology institutions.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.