Postdoctoral Fellow

Prospective fellows will perform MALDI-MSI on a Bruker timsTOF fleX, collaborate with our scientists across disciplines, and pursue mentored independent research in the pursuit of developing and applying advanced imaging Mass Spectrometry methods.

This role offers hands-on training in cutting-edge imaging platforms, data analysis, and scientific communication in a well-equipped core facility. Primary, fellows will perform MALDI-based mass spectrometry imaging experiments using a Bruker timsTOF fleX, preparing samples, and acquiring, processing, and interpreting data. Candidates will also collaborate with NIEHS investigators from diverse research areas to design and execute MS imaging studies. Additionally, fellows will:

• Develop and optimize MSI methods, including improvements in spatial resolution, sensitivity, throughput, and multimodal integration.
• Conduct independent research leading to peer-reviewed publicationson novel MS imaging applications and methodologies.
• Analyze and interpret complex datasets using appropriate software and statistical tools.
• Document their methods, develop standard operating procedures, and contribute to best practices within our core facility.
• Present results to collaborators, at scientific meetings, and at internal and external seminars.
• Gain experience with a wide range of mass spectrometry, e.g. Orbitrap, timsTOF, triple quadruples.
• Receive training in all of our core facility operations, scientific project management, and numerous collaborative team research models

Finally, we offer opportunities for Postdocs to cross-training in liquid chromatography and mass spectromery workflows such as metabolomics, lipidomics, proteomics, and customized analytical methods.

Prospective Candidates must have:

• A Ph.D. in analytical chemistry, biochemistry, biophysics, biology, or related discipline - Experience with mass spectrometry
• Strong experimental, analytical, and problem-solving skills
• The ability to work independently as well as collaboratively in a multidisciplinary research environment
• Excellent written and verbal communication skills

Preferably, candidates will have:

• Experience with MALDI-MS or mass spectrometry imaging, familiarity with tissue preparation, matrix application, and spatially resolved data analysis
• Experience with metabolomics, lipidomics, or proteomics workflows
• Data analysis experience (mass spectrometry vendor software, R, Python, etc.)

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.