Postdoctoral Fellow in Gene Regulation

Studying gene regulation is critical to understanding how disruptions in developmental gene expression lead to birth defects and enable earlier diagnosis and potential intervention strategies. We investigate how genome folding not only fits the long DNA fiber within the constraints of the nuclear space but also is used as a critical mechanism of gene regulation during cell fate specification. This is a key fundamental question because transcription of many genes required for healthy development is controlled by non-coding regulatory elements—known as enhancers—that can be found at large genomic distances from their target genes. Our long-term scientific goal is to decipher how within a crowded nucleus, distal enhancers are guided specifically to their target genes and which mechanisms prevent off-target activation. Postdocs will be able to start their own research program or lead ongoing projects on these topics. Postdoctoral positions at NIH are fully funded. Learn more about our research at: https://www.nichd.nih.gov/research/atNICHD/Investigators/rocha

Ph.D.-level experience in at least one of the following is required: mouse development, mouse genetics, epigenetics, massively parallel sequencing-based techniques, or computational biology.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.