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Job

Postdoctoral Position in Antibody Engineering

Organization

National Cancer Institute, Bethesda, MD and surrounding area

Scientific focus area

Biomedical Engineering and Biophysics, Immunology, Molecular Biology and Biochemistry

A postdoctoral position in antibody engineering is available in the Antibody Engineering Program (AEP) core, Laboratory of Molecular Biology, NCI/NIH (Bethesda, MD). Directed by Dr. Mitchell Ho, the AEP focuses on discovery and engineering of shark- and camel-derived single-domain antibodies (nanobodies) in collaboration with NCI and NIH labs, with applications in cancer therapy and diverse basic and translational research areas.

About the position

The successful postdoctoral candidate will work on projects involving the isolation of nanobodies using phage display technology; engineering of nanobodies using AI/machine-learning approaches and wet-lab directed evolution; and molecular and cellular characterization of nanobodies in relevant disease models. These nanobodies can be applied to a broad range of basic and translational research efforts, including protein structure studies, super-resolution microscopy imaging, monospecific and multispecific binders, engineered immune cells such as CAR T cells, radiopharmaceuticals, in vivo tumor imaging agents, protein degraders, immunotoxins, and many other rapidly advancing areas in biology and medicine.

The postdoctoral fellow will lead innovative research projects, perform nanobody screening and other bench-based experiments, analyze and interpret data, prepare project reports and manuscripts for publication, and present findings at national and international conferences. The position may also include mentoring and training summer interns and postbaccalaureate fellows. This is an excellent opportunity for a dedicated researcher to advance their career in a highly collaborative and supportive environment while working with a multidisciplinary team of clinicians and basic scientists. For more information, please see:

Apply for this vacancy

What you'll need to apply

To apply, please send the following materials to Dr. Ho ([email protected]):

  1. A cover letter describing research interests, relevant experience, and career goals
  2. Curriculum vitae (including bibliography)
  3. Names and contact information for at least three references, preferably research supervisors

Contact name

Mitchell Ho

Contact email

[email protected]

Qualifications

Highly motivated candidates with a Ph.D. or M.D./Ph.D. and a strong background in molecular biology and biochemistry are encouraged to apply. Proficiency in a broad range of laboratory techniques is highly desirable. Bioinformatics experience analyzing large DNA sequence datasets is considered an advantage. The successful candidate should demonstrate the ability to conduct independent research and have a strong record of scientific publications. Excellent communication and interpersonal skills, including the ability to work effectively in a collaborative team environment, are essential.

Disclaimer/Fine Print

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.

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