Staff Scientist

Type 2 diabetes and obesity have emerged as major threats to human health in the 21st century. The Wess Section (Molecular Signaling Section) at LBC of the NIDDK seeks to understand how G protein-coupled receptors (GPCRs) regulate blood glucose levels and energy expenditure, two key factors involved in the development of type 2 diabetes. We use novel mouse models, combined with pharmacological, molecular, biochemical, and cell biological techniques, to address the following fundamental questions:

(1) How do specific GPCR-G protein signaling pathways in specific organs or cell types affect blood glucose levels and whole-body energy expenditure?

(2) What are the in vivo metabolic roles of GPCR-associated proteins such as beta-arrestin-1 and beta-arrestin-2?

The Staff Scientist will carry out studies examining the roles of different GPCR/G protein signaling pathways regulating the function of alpha- and beta-cells of mouse pancreatic islets, generating and analyzing mutant mice that express designer GPCRs, known as DREADDs. Moreover, she/he will use knockout technology to study the metabolic roles of specific G protein-alpha subunits, as well as of beta-arrestin-1 and -2, in mouse alpha- and beta-cells. This work will likely help identify novel targets for the treatment of type 2 diabetes and related metabolic disorders.

Candidates should have a Ph.D. or M.D. degree and a minimum of 3 years of experience working with pancreatic islets. Preferably, Candidates will have:

• At least 5 years of postdoctoral experience in mouse genetics and performance of metabolic, biochemical, pharmacological, and cell biological experiments
• Proficiency in a wide range of metabolic techniques
• A strong publication record

DHHS is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs. Applications from underrepresented groups and female candidates are particularly encouraged. Salary is dependent on qualifications and experience. A full package of Civil Service benefits is available, including retirement, health and life insurance, long-term care insurance, leave and savings plan (401 (k) equivalent). Appointments for this position are made as Staff Scientist and are open to all sources. The position is based in Bethesda, Maryland.