Resource

FAES Science Insight Series: Trust Through Knowledge Grounding: AI Agents in Biomedicine

Published: February 2026

Speaker: Zhiyong Lu, PhD FACMI, FIAHSI, Senior Investigator, NIH, Professor of Computer Science (Adjunct), UIUC

About this event

Date and time of event: 04/02/2026 11:45 – 1:00 pm ET (must arrive by 12PM)

This is an in-person event

Hosted by: OD

This series invites Principal Investigators, Senior Scientists, and Senior Clinicians to share cutting-edge research and developments in their fields. Each session includes a 20-30 minute presentation followed by a Q&A or journal club discussion, fostering deeper insights and scholarly exchange. Lunch is provided on a first come first served basis.

Recent advances in large language models (LLMs) have enabled powerful AI agents for biomedical research, yet their adoption in high-stakes settings remains limited by concerns about hallucination, opacity, and reliability. In this talk, I discuss how expert-curated domain knowledge can be used to help mitigate these challenges in general-purpose LLMs. Drawing on real-world systems and case studies such as GeneAgent (Nature Methods 2025), I will highlight design principles for building AI agents that are scientifically sound, interpretable, and suitable for biomedical research and clinical applications.