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OTHER LEARNING OPPORTUNITIES FOR STAY-AT-HOME SCIENTISTS

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Two Online NIH courses are still open: Principles of Clinical Pharmacology and Principles and Practice of Clinical Research
 

Registration for the 2021-2022 NIH Introduction to the Principles and Practice of Clinical Research (IPPCR) course is now open!

This free, self-paced, online course runs from September 1, 2021 to August 1, 2022. Graduate students, post-doctoral scholars, medical, dental, and pharmacy students, scientists, nurses, and other health professionals are encouraged to enroll now.

The IPPCR course is a lecture series from thought-leaders around the world covering:

  • Study Designs, Measurement and Statistics
  • Ethical, Legal, Monitoring, and Regulatory Considerations
  • Preparing and Implementing Clinical Studies
  • Communicating research findings and other topics 

To register, please visit the IPPCR website at https://ocr.od.nih.gov/courses/ippcr.html or contact the course coordinator at ippcr2@mail.nih.gov.    

Please feel free to share the course information website link with any internal or external colleagues. We aim to continue to make this course a national and international success!   

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Rebecca Hwang, Office of Clinical Research, rebecca.hwang@nih.gov, 301-451-1468, and/or the Federal Relay (1-800-877-8339).

 
 

Registration is now open for the 2021-2022 NIH Principles of Clinical Pharmacology (PCP) Course!

The PCP course is a free online lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. Topics covered in the course include pharmacokinetics, drug therapy in special populations, drug discovery and development, and pharmacogenomics. 

PCP Course Details

The course will be of interest to graduate students, post-doctoral scholars, medical and pharmacy students, scientists, and health professionals interested in expanding their pharmacology knowledge base. For additional information on the course, please visit the website above or contact the course coordinator at odpcp@mail.nih.gov. Please feel free to share the course information with any internal or external colleagues that you feel may benefit from the course. 

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Rebecca Hwang, NIH Office of Clinical Research, odpcp@mail.nih.gov, 301-451-1468, and/or the Federal Relay (1-800-877-8339).


CIT Technology Training Program - Winter Training Term (1-6-21)
 
Winter is the time for comfort, for warmth beside a fire, and for our Winter training term to begin.
As the outbreak of COVID-19 continues, we will present our training sessions via WebEx; at this time, space will be limited for better facilitation.
 
Would you like to learn more about virtual meetings?  Are you looking to make your documents Section 508 compliant?  Are you using Microsoft Office 2016 applications?  We can be of assistance.  There is no charge for most of the courses and seminars (any charges would be listed with the course description), and registration is open to NIH staff as well as all users of CIT computing facilities. Please use the links below to find more details about the courses and to register online.
 
Would you like to learn more about Microsoft Office 2016 applications:
Do you work with a Mac:
Are you interested in unified communications and web technologies:
We also have Accessibility sessions available:
Additional sessions include:
Information to join a webinar session will be sent to those who are enrolled via e-mail from the instructor. Any documents required for the training will be included. If you have not received this information by the day of the session, please e-mail us at cittraining@mail.nih.gov.
 
If you have expertise you would consider sharing with those in the NIH community, please contact us. We have extensive instructor support services (e.g. obtaining publications for instructors, polishing course descriptions, e-mailing course materials, setting up projection systems, etc.) to make efficient use of your time and make your presentation effective.
 
We also coordinate outside training personnel, classroom rental, resources, registration, and other related activities in support of training events for a nominal fee to cover complete cost recovery.
If you have any questions or need assistance with registering for sessions, please contact us by email at CITTraining@mail.nih.gov.
Science Communication in the Context of a Pandemic: Highlights and Lessons
September 24, 2020
 
During the rapidly evolving COVID-19 pandemic, timely, accurate, and concise communication is vital to ensure public understanding of the scientific basis for the advice they receive. The panelists will identify difficulties in science communication scenarios where there is uncertainty and urgency, together with optimal strategies for scientists and science communication professionals to cope with these challenges.
SACNAS (Society for Advancement of Chicanos/Hispanics and Native Americans in Science)
 
On-Demand Webinar: Public Health in Indigenous Populations 

In this new webinar, Donald Warne, MD, MPH, (Oglala Lakota) shares what Native people and communities need to be aware of and consider when dealing with COVID-19, by providing an in-depth look into Indigenous health, history, and policy. Dr. Warne is Associate Dean of Diversity, Equity, and Inclusion; Director, MPH Program & INMED Program; and Professor, Family & Community Medicine at UND School of Medicine and Health Sciences.

Watch now.

ASCB (American Society for Cell Biology) Webinars
 

NLM/MLA Leiter Lecture - Dr. John Brownstein On Digital Epidemiology And The Covid-19 Pandemic: August 11, 2020
 
John S. Brownstein is professor of biomedical informatics at Harvard Medical School and is the chief innovation officer of Boston Children’s Hospital. He also directs the Computational Epidemiology Lab and the Innovation and Digital Health Accelerator, both at Boston Children’s Hospital. Brownstein is also Uber’s health care advisor and cofounder of the digital health companies Epidemico and Circulation. He will be speaking on the surveillance, control, and prevention of disease, the development and application of data mining, and citizen science to public health in relation to his work with the COVID-19 pandemic.

 
Published by Scientific American, information updated as we learn more
NINR Artificial Intelligence Virtual Boot Camp
 
In August, the National Institute of Nursing Research (NINR) will hold a four-day virtual boot camp to explore the impact that Artificial Intelligence (AI) has in the evolving healthcare environment, and overall efforts to improve the quality of care for patients and families. The goal is to enable attendees to understand basic principles of AI and how clinicians can form strategic alliances with data scientists to carry out research on data-driven intelligent hardware and software approaches to health-related issues. The event will be broadcast live via VideoCast and archived for later viewing.
 
Objectives:
  • Describe the field of Artificial Intelligence (AI) and explore the role of AI to promote health, and to prevent illness.
  • Discuss strategies to build partnerships and collaborations among clinicians and scientists.
  • Explore AI data collection, including ethical, legal, and social implications.
  • Analyze clinical and translational AI applications that can reach more diverse patient populations and improve the safety, efficacy, and quality of healthcare.
Boot Camp Agenda:
  • [8/3/2020] Session I: Innovations and Improvements in Health Outcomes
  • [8/4/2020] Session II: Clinical Applications
  • [8/5/2020] Session III: Ethical, Legal, And Social Implications
  • [8/6/2020] Session IV: Collaborative Science

ABRCMS (The Annual Biomedical Research Conference for Minority Students) has created ABRCMS Online 

ABRCMS Online is an extension of the conference that allows the biomedical sciences community to continue learning, with resources for students, trainees, faculty, and community.

NLM’s Ada Lovelace Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”

Tackling Diabetic Retinopathy in a Safety Net Healthcare Setting with Telehealth and Machine Learning

Diabetic retinopathy is the leading cause of blindness in working age adults in the United States. It is challenging to address in both rural and urban underserved settings, which suffer from shortages of eye specialists. This talk will describe the approach taken to address this condition in a medically underserved area (South Los Angeles) by researchers in the Center for Biomedical Informatics at Charles R. Drew University of Medicine and Science, using telehealth and machine learning on data from patient electronic health records.

Brief Bio:

Omolola Ogunyemi, PhD, FACMI is the Director of Charles R. Drew University of Medicine and Science's Center for Biomedical Informatics and a co-chair of the UCLA CTSI's biomedical informatics program. She is also an Adjunct Professor of Radiological Sciences in the David Geffen School of Medicine at UCLA with the Medical and Imaging Informatics group. She was recently a Principal Investigator on a National Library of Medicine (NLM)-funded R01 grant to develop a variety of machine learning approaches for identifying patients with latent/undiagnosed diabetic retinopathy from electronic health records or digital retinal images. Dr. Ogunyemi’s research at the CBI focuses on novel biomedical informatics solutions for problems that affect medically underserved communities. Her research interests include computerized medical decision support, reasoning under uncertainty, 3D graphics and visualization, and machine learning.

Prior to her role at Charles R. Drew University of Medicine and Science, Dr. Ogunyemi was a biomedical informatics faculty member in the Department of Radiology at Brigham and Women's Hospital and Harvard Medical School. She was also a member of the affiliated faculty in the Harvard-MIT Division of Health Sciences and Technology. Dr. Ogunyemi holds an undergraduate degree in Computer Science from Barnard College, Columbia University and an M.S.E, and Ph.D. in Computer and Information Science from the University of Pennsylvania.

How to Join:

This talk will be broadcast live and archived at https://videocast.nih.gov/watch=43839
Date: Tuesday, October 12, 2021
Time: 3:00 - 4:00 PM ET
 

Interpreting services are available upon request. Individuals with disabilities who need reasonable accommodation to participate in this lecture should contact Ms. Queenmoore Okeke at queenmoore.okeke@nih.gov  or the Federal Relay (1-800-877-8339).

Sequence-Structure-Function Modeling for the 3D Genome
 
The National Library of Medicine’s Ada Lovelace Computational Health Lecture Series presents, "Sequence-Structure-Function Modeling for the 3D Genome", Thursday, January 28, 2021 | 2:00 to 3:00 pm | NIH Videocast
 
The talk will be delivered by Katherine S. Pollard, PhD, Director, Gladstone Institute of Data Science and Biotechnology, Professor and Investigator, Chan Zuckerberg Biohub at the University of California San Francisco.
 
Ada Bryon Lovelace developed the idea of Poetical Science, which emphasizes the importance of intuition and image in mathematics and science. Poetical Science comprises three key features: observation, interpretation, and integration. A brilliant mathematician, Lovelace is broadly recognized as the first computer programmer. A key example of Poetical Science is her observation of a punch card-driven loom in a weaving factory that subsequently led to the mathematics that operationalized Charles Babbage's computing machine. In this talk, Dr. Pollard will discuss how the human genome sequence folds in three dimensions (3D) into a rich variety of locus-specific contact patterns.
 
Despite growing appreciation for the importance of 3D genome folding in various aspects of cell biology, there is a lack of models for relating mutations in genome sequences to changes in genome structure and function. Towards that goal, Dr. Pollard and her colleagues discovered that the organization of gene regulatory domains within this structure and the specific sequences that sit at boundaries between domains are under strong negative selection in the human population and over primate evolution. Motivated by this signature of functional importance, Dr. Pollard’s team developed a deep convolutional neural network, called Akita, that accurately predicts genome folding from DNA sequence alone. Representations learned by Akita underscore the importance of the structural protein CTCF but also reveal a complex grammar beyond CTCF binding sites that underlies genome folding. Akita has enabled rapid in silico predictions for effects of sequence mutagenesis on the 3D genome, including differences in genome folding across species and in disease cohorts, which are being validated with CRISPR-edited genomes. This prediction-first strategy exemplifies Dr. Pollard’s vision for a more proactive, rather than reactive, role for data science in biomedical research.
 
Dr. Pollard earned her BA at Pomona College and her master’s degree and PhD in biostatistics from UC Berkeley. At Berkeley, she developed computationally intensive statistical methods for the analysis of microarray data with applications in cancer biology. She implemented these approaches in Bioconductor, an open-source software program used with high-throughput genomic data. As a comparative genomics postdoctoral fellow at UC Santa Cruz, Pollard participated in the Chimpanzee Genome Project and used this sequence to identify the fastest-evolving regions in the human genome, known as Human Accelerated Regions.
 
Before joining Gladstone, Dr. Pollard was an assistant professor in the Genome Center and Department of Statistics at UC Davis. She was awarded the Thomas J. Watson Fellowship in 1995 and the Sloan Research Fellowship in 2008. Dr. Pollard is a fellow of the California Academy of Sciences and a Chan Zuckerberg Biohub Investigator. In 2018, she became the founding director of the Gladstone Institute of Biotechnology and Data Science. Dr. Pollard is a member of the American Society of Human Genetics, the American Statistical Association, and the International Society for Computational Biology.
This lecture is sponsored by the National Library of Medicine (NLM) Acting Scientific Director and David Landsman, PhD, Chief, Computational Biology Branch at NLM's National Center for Biotechnology Information.
 
This lecture will be live-streamed globally, and subsequently archived and available for viewing, at: https://videocast.nih.gov/watch=41362.
 
Individuals with disabilities who need reasonable accommodation to participate in this event should contact Valerie Bartlett, bartletv@mail.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.
 
Submit questions during the meeting to: NLMEPInfo@mail.nih.gov.
 
Implications of Poetical Science for Advancing Health Equity through Information Visualization

Suzanne Bakken, PhD, RN, FAAN, FACMI, FIAHSI, Alumni Professor of Nursing and Professor of Biomedical Informatics at Columbia University presented the National Library of Medicine’s Ada Lovelace Computational Health Lecture on December 7, 2020. The title of her talk was “Implications of Poetical Science for Advancing Health Equity through Information Visualization”
In this talk, Dr. Bakken will use the lens of Poetical Science to describe a program of research focused on advancing health equity of urban Latinos through use of information visualization. This will include the integration of perspectives from the fields of health equity, nursing science, health literacy, health communication, and information visualization.
 
Suzanne Bakken, PhD, RN, FAAN, FACMI, FIAHSI, is the Alumni Professor of Nursing and Professor of Biomedical Informatics at Columbia University. Following her doctorate in Nursing at the University of California, San Francisco, she completed a post-doctoral fellowship in Medical Informatics at Stanford University. Her program of research has focused on the intersection of informatics and health equity for more than 30 years and has been funded by AHRQ, NCI, NIMH, NINR, and NLM. Dr. Bakken’s program of research has resulted in more than 300 peer-reviewed papers. At Columbia Nursing, she leads the NINR-funded Precision in Symptom Self-Management (PriSSM) Center and Reducing Health Disparities Through Informatics (RHeaDI) Pre- and Post-doctoral Training Program.
 
She is a Fellow of the American Academy of Nursing, American College of Medical Informatics, International Academy of Health Sciences Informatics, and a member of the National Academy of Medicine. Dr. Bakken has received multiple awards for her research including the Pathfinder Award from the Friends of the National Institute of Nursing Research, the Nursing Informatics Award from the Friends of the National Library of Medicine, the Sigma Theta Tau International Nurse Researchers Hall of Fame, and the Virginia K. Saba Award from the American Medical Informatics Association. Most recently, she was the first nurse recipient of the Francois Gremy Award from the International Medical Informatics Association. Dr. Bakken currently serves as Editor-in-Chief of the Journal of the American Medical Informatics Association and a member of the National Library of Medicine’s Board of Regents.
This lecture is sponsored by Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine and David Landsman, PhD, Chief, Computational Biology Branch at the NLM’s National Center for Biotechnology Information.
 
This lecture will be live-streamed globally, and subsequently archived, by NIH video casting: https://videocast.nih.gov/watch=40070.
 
Dynamic Genome Rearrangements in the Ciliate Oxytricha

The talk was delivered on October 13, 2020, by Dr. Laura Landweber, PhD, Professor of Biochemistry & Molecular Biophysics and of Biological Sciences, Columbia University.
 
Topic: The ciliate Oxytricha trifallax possesses a complex pair of genomes, and massive DNA rearrangements produce a highly fragmented but functional somatic macronucleus from a complex germline micronucleus. This process eliminates nearly all noncoding DNA, including transposons, and rearranges over 225,000 short DNA segments to produce a second genome containing thousands of gene-sized "nanochromosomes”. The mature, somatic genome contains over 17,000 nanochromosomes. Noncoding RNAs regulate the entire process of genome rearrangement. Millions of parental 27nt small RNAs provide the critical information to mark and protect the retained DNA segments of the genome. These and other processes illustrate the multifaceted ability of noncoding RNAs to transmit heritable information to the next generation.
 
Dr. Laura Landweber is a Professor in the Departments of Biochemistry & Molecular Biophysics, Biological Sciences, and Systems Biology, in the Colleges of Physicians & Surgeons and Arts & Sciences. Prior to moving her lab to Columbia University Medical Center she was faculty at Princeton University from 1994-2016, and a Junior Fellow of the Society of Fellows at Harvard University, where she received her PhD in 1993. She has authored over 150 publications in molecular and evolutionary biology and edited 3 books, in areas ranging from genetics and evolution to biological computation. She is President (2017) of the Society for Molecular Biology and Evolution (SMBE) and has served on several panels, working groups, and advisory committees for the NSF, NIH, and NASA, including co-chairing the NHGRI Comparative Genome Evolution Working Group from 2003-2007. Recent awards include a Guggenheim fellowship (2012) and a Blavatnik award for young scientists (2008), and she was elected a Fellow of AAAS for probing the diversity of genetic systems in microbial eukaryotes, including scrambled genes, RNA editing, variant genetic codes, and comparative genomics. Her work investigates the origin of novel genetic systems and complex genome architectures, using the ciliate Oxytricha as a model. Recent discoveries include the ability of small and long non-coding RNA molecules to program genome organization across generations, bypassing the information encoded in DNA.
 
This lecture is sponsored by David Landsman, PhD, Director of the Computational Biology Branch, NCBI, and Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine
This lecture is archived at https://videocast.nih.gov/watch=38902
 
Computational Tools for the Classification, Prediction, and Characterization of a Pandemic
 
The first lecture in NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”, was presented Wednesday, June 24, 2020, by by Dr. John H. Holmes, PhD, FACE, FACMI, FIAHSI, Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine.
 
Traditional methods of epidemic modeling continue to be used fruitfully for characterizing outbreaks and predicting the spread of disease in populations. However, these methods, typically rely on what are known as “compartment models”, requiring assumptions that are not necessarily sensitive to the ever-changing environmental, behavioral, temporospatial, and social phenomena that influence disease spread. Compartment models can be enriched by the judicious use of robust methods drawn from the field of artificial intelligence that allow us to model more accurately and more quickly the population and disease dynamics that are central to developing policies for prevention, detection, and treatment. We will explore these approaches, including some that are currently in use as well as a proposal for novel, next-generation machine learning tools for epidemiologic investigation.
 
This lecture was sponsored by Valerie Florance, PhD, Associate Director of the National Library of Medicine, Division of Extramural Programs and Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine
 
A recording of the lecture is available: https://videocast.nih.gov/watch=37909.

Supporting People With Addiction During Covid-19: A Webinar Series From The National Academy Of Medicine
 
Individuals experiencing addiction are a vulnerable population that have been significantly impacted by the COVID-19 pandemic. Physical distancing protocols have separated patients from their clinicians, made medications to treat addiction much more challenging to obtain, and shuttered many long-term recovery groups. 
 
A new webinar series from the NAM and the American Society of Addiction Medicine will provide insight and targeted guidance on how to ensure that these individuals are cared for and protected during this ongoing public health crisis.

NIH Office of Behavioral and Social Sciences Research presentation: "What are we learning from talking to scientists about scientific communication?" May 19, 2020, 2:00 - 3:00 pm EDT
 
Presentation Overview:
In recent years, Dr. John Besley has shifted his research from the study of public opinion about science to trying to understand scientists' opinion about the public. As part of this work, he and his collaborators have advanced a framework for strategic science communication that emphasizes setting clear behavioral goals and then working backwards to identify communication objectives that have the potential of affecting desired behaviors, as well as tactics to help achieve the communication objectives. This perspective puts identifying and prioritizing specific communication objectives at the core of being an effective communicator.
 
Dr. Besley will share his thinking along with selected data from his surveys and interviews of scientists.
John Besley, Ph.D., is Ellis N. Brandt Professor of Public Relations at Michigan State University.
The slides will be available with closed captioning on OBSSR’s website approximately two weeks following the webinar: https://obssr.od.nih.gov/what-we-are-learning-from-talking-to-scientists-about-science-communication.

Harvard T.H. Chan School of Public Health Activities:
 
FORUM:
 
Series
 
Special Events
 
Podcasts of Forum events with The World from PRX & WGBH
 
Harvard T.H. Chan School of Public Health YouTube

National Academy of Sciences COVID-19 Update
 
Saturday, April 25, 2020
2:00 p.m. EDT
  • Jeremy Farrar, Director, Wellcome Trust
  • Anthony S. Fauci, Director, National Institute of Allergy and Infectious Diseases
  • George F. Gao, Director-General, Chinese Center for Disease Control & Prevention
  • Susan R. Weiss, Professor of Microbiology, Perelman School of Medicine, University of Pennsylvania
  • Richard J. Hatchett, CEO, Coalition for Epidemic Preparedness Innovations
  • Sanjay Gupta, Chief Medical Correspondent, CNN

Virtual Radcliffe Discussion Series: Health Inequity in The Age Of Covid-19
 
The Radcliffe Institute is launching a new Virtual Radcliffe programming platform to offer lectures and conferences that connect leading scholars and practitioners with the public and advance discourse on pressing issues. Beginning on Thursday, April 23, Radcliffe will host a series of discussions examining the grave health inequities revealed and exacerbated by COVID-19, which is disproportionately impacting vulnerable and marginalized communities. Recordings are now available.
 
April 28, 2020
International experience in recent months has powerfully illustrated that the COVID-19 virus has particularly harmful and disproportionate effects on already vulnerable populations. Mary Bassett and Khalil Gibran Muhammad will discuss inequity and public health in the time of COVID-19, exploring how the virus encounters existing inequalities, replicates these inequalities, and, in many cases, amplifies them.
 
Thursday, April 23, 2020
As COVID-19 threatens to push hospital resources beyond capacity, states, hospitals, and advocacy organizations have formulated protocols to address potential discrimination against persons with disabilities. Highly influential statements by the Arc and the University of Pittsburgh are setting new standards for the ethical treatment of persons with disabilities. This Radcliffe webinar places these triaging policies within the context of the history of disability civil rights, culture, and bioethics and considers what is necessary to achieve equitable health outcomes for persons with disabilities during this time of crisis.

1918 Spanish Flu Historical Documentary | Swine Flu Pandemic | Deadly Plague of 1918
 
Historical documentary about 1918 Swine Flu or Spanish Flu and the role of World War I in spreading the disease among troops making it into a worldwide plague of devastating proportions. The video covers where it began, how and where it spread, the symptoms, how it affected America and whether it could happen again.

NLM Research Symposium: Reporting, Recording, and Remembering the 1918 Influenza Epidemic
 
The symposium will be held virtually on Wednesday, April 29, 2020, 2:00-4:00pm ET, via streamlined Webex to reduce bandwidth usage, while being livestreamed and subsequently archived by NIH Videocasting as part of its archive of past NLM history of medicine events.
 
Watch and hear the program via this URL: https://videocast.nih.gov/watch=36347
Join us to learn the research outcomes of Virginia Tech students studying the history of data in social context through individual and collaborative primary-source research here at the NLM and elsewhere, and as part of their course Topics in the History of Data in Social Context, being taught by Dr. E. Thomas Ewing.
 
During the symposium, the students will present their research on various aspects of the 1918 pandemic, including newspaper reporting at the peak of the epidemic (late September to early November 1918), contemporary social distancing policies and procedures, and how contemporaries determined that the epidemic was ending, and how they remembered the remarkable experience of this intense, but relatively brief, crisis in community health. Discussants will include Dr. Nancy Bristow of the University of Puget Sound and author of American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford University Press, 2012), among others to be announced.
 
All are welcome to tune-in to this research symposium which advances the NLM 2017-2027 strategic plan emphasizing data-driven discovery, enhanced stakeholder engagement, and the role of libraries and archives in providing trusted information. Reporting, Recording, and Remembering the 1918 Influenza Epidemic is sponsored by the NLM History of Medicine Division in cooperation with the National Endowment (NEH) for the Humanities Office of Digital Humanities—as part of the ongoing NLM/NEH partnership to collaborate on research, education, and career initiatives.
 
Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact Dr. Stephen Greenberg at greenbes@mail.nlm.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.

PBS Film: “Ken Burns presents The Gene: An Intimate History” -- aired April 7 & 14. You can now stream it from https://www.pbs.org/kenburns/the-gene/.
 
A new PBS film, “Ken Burns presents The Gene: An Intimate History,” based on the book by Dr. Siddhartha Mukherjee, will air in two parts: April 7 at 8 pm ET and April 14 at 8 pm ET.  Dr. Mukherjee shared his insights on the book with NIH staff in April 2017 as part of the NIH Big Read series (
For more than two years, the National Human Genome Research Institute (NHGRI) has been proud to support the education and outreach associated with this film, and the NIH Office of the Director, the National Institute of General Medical Sciences, and others across NIH have also contributed substantially.
The film describes the history of genetics, from Mendel to modern day. It brings to life the story of today’s revolution in medical science through present-day tales of patients and doctors at the forefront of the search for genetic treatments, interwoven with a compelling history of the discoveries that made this possible and the ethical challenges raised by the ability to edit DNA with precision.
 
The filmmakers interviewed many NIH staff and NIH-funded researchers in making the documentary, and you will see multiple NIH employees featured in the final cut. For example, Dr. Francis Collins and I were given the opportunity to recount the excitement of the Human Genome Project and its incredible legacy, including the birth of NHGRI and the increased investments in genetics and genomics by all parts of NIH.

NIH Begins Study to Quantify Undetected Cases of Coronavirus Infection
 
Published April 10, 2020

New Science Webinar from AAAS: Coronavirus: A Survival Guide
 
Thursday, 16 April 2020, 11 a.m. Eastern, 8 a.m. Pacific, 4 p.m. UK (BST), 5 p.m. Central Europe (CEST)
Now available on demand.
  • What the coronavirus is and how it makes you sick
  • What you can do to protect yourself, and keep your friends and family safe
  • How you can build resilience to deal with this new way of life
  • What the end of this pandemic might look like 
  • Where you can get the latest information about the virus that is accurate and trustworthy.

FAES Offerings
 
New January Intersession with Special Coding Course for Beginners
FAES is pleased to offer BIOF101 Introductory Coding, a new online course that will teach novice students the needed programming skills for success in academic, scientific and industrial settings. Students will first learn the basic components of programming, such as variables, conditionals, loops, object-oriented programming and simple data structures.  Students will also be taught how to properly prepare a computer for efficient and effective programming. Students will then apply basic programming principles by using the Python programming language to complete assignments that reflect real-word tasks. Finally, students will put together a plan for further programming education. No prior knowledge of programming is necessary to be successful in this class.
 
BIOF101 will run from January 11 - January 29th.  For students affiliated with NIH, tuition is $75 and for non-NIH students, tuition is $100. To register, go to https://faes.org/courses.
 
If you have any questions, please email registrar@faes.org or call 301-496-7976. Individuals with disabilities who need reasonable accommodation to take FAES classes should contact registrar@faes.org. Requests should be made at least five days in advance.
 
Upcoming FAES Online Workshops: ... Register Now!
 
Pricing varies by workshop. Pricing and registration information is at: https://faes.org/workshops-conferences.
Questions: registrar@faes.org or call 301-496-7977
Individuals with disabilities who need reasonable accommodation to take FAES classes should contact registrar@faes.org. Requests should be made at least five days in advance.
 
An afternoon with an NIH PI, a new lecture series hosted by FAES
 
We are excited to announce a new virtual lecture series called “An afternoon with an NIH PI” during May 2020 in which prominent scientists from the NIH will share their latest research and insights into their career path. Attendees will be able to submit questions during and after the seminar via chat, and those will be discussed at the end of the seminar. Recordings of all the lectures are now available at https://faes.org/content/an-afternoon-with-an-NIH-PI.
 
  1. A Drug's Purpose: From ED to Viral Hepatitis to COVID-19
    Jake Liang​, MD | NIH Distinguished Investigator, Chief, Liver Diseases Branch, NIDDK
  2. Role of the Microbiota in Immunity and Repair
    Yasmine Belkaid, PhD​ | Chief, Metaorganism Immunity Section, NIAID
  3. Big-Small, Tall-Short, Big Ears-Little Ears: What is the Genetics of it All?
    Elaine Ostrander, PhD | NIH Distinguished Investigator, Cancer Genetics and Comparative Genomics Branch, NHGRI
  4. Self-Renewal, Differentiation and Transformation in Hematopoiesis and in Science
    Cynthia Dunbar, MD | Chief, Translational Stem Cell Biology Branch, NHLBI
  5. From Axon Damage to Disease: Common Pathways in Neurodegeneration
    Claire Le Pichon, PhD | Investigator, Unit on the Development of Neurodegeneration, NICHD
  6. scRNAseq Developmental Trajectories to Investigate Differentiation
    Jeff Farrell, PhD | Earl Stadtman Investigator, Unit on Cell Specification and Differentiation, NICHD
  7. Biological Imaging at High Spatiotemporal Resolution (and How I Got into This)
    Hari Shroff, PhD | Senior Investigator, Laboratory of High Resolution Optical Imaging, NIBIB

NIH COVID-19 Lecture Series
 
Fall 2020 Lectures
 
The NIH COVID-19 Scientific Interest Group (SIG) Lecture Series will resume on October 1, 2020. We are writing to let you know that the lecture series has a new day and time: the first and third Thursday of each month at 12:00 pm (ET). The lectures will be available live and archived at videocast.nih.gov.
 
October 1: Paul Bieniasz (Rockefeller University) "Neutralizing Antibodies to SARS-CoV-2."
October 15: Kizzmekia Corbett (NIH) "SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness."
November 5: E. John Wherry (Perelman School of Medicine, UPenn) "Immune Profiling to Understand COVID-19 Pathogenesis."
November 19: Christine Grady (NIH) "Ethical Quandaries in the COVID-19 Pandemic."
December 3: Helen Su (NIH) "Genetic Studies Illuminating Pathways Important for Controlling COVID Disease."
December 17: James J. Collins (Wyss Institute at Harvard) "Harnessing Synthetic Biology and Deep Learning to Address the COVID-19 Pandemic."
 
For more information about the COVID-19 Scientific Interest Group, refer to https://oir.nih.gov/sigs/covid-19-scientific-interest-group. Sign-language interpreters can be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Jacqueline Roberts, robertsjm@od.nih.gov, 301-594-6747, or the Federal Relay, 800-877-8339.
— The COVID-19 SIG Leadership
 
Spring and Summer 2020 Lectures
 
SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects," by Alessandro Sette, Ph.D., professor and member of the La Jolla Institute for Immunology, La Jolla, CA, July 29. This lecture is now archived.
For his lecture, Dr. Sette will review data examining the nature and specificity of T cell responses to SARS-CoV-2 from convalescent and acute donors, and in non-exposed subjects.  Over the past three decades, the Sette lab has defined in chemical terms the specific structures that the immune system recognizes, and it has capitalized on this knowledge to measure and understand immune responses.  This approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.  Turning to SARS-CoV-2, Dr. Sette and his colleagues applied this approach to provide the one of the first assessments of whether the immune system can mount a substantial and lasting response, finding evidence of T cell reactivity against and pre-existing immunity to SARS-CoV-2.  Dr. Sette will highlight these and other findings in his talk.
 
COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far," by Stefania Pittaluga, M.D., and David Kleiner, M.D., Ph.D., senior research physicians in the NCI-CCR Laboratory of Pathology, July 22. This lecture is now archived.
 
Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published.  Although most patients experience mild symptoms, some have serious complications—including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia—that contribute to the high mortality rate.  Autopsies can offer a better understanding of the underlying pathophysiology.  Unfortunately, few autopsies were performed early in the pandemic because of the potential risks.  Untreated patients who died of SARS-CoV-2 were rarely autopsied.  Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs.  We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH.  We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.
 
Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing," by Dan Anderson, Ph.D., professor of chemical engineering and of health sciences and technology at the MIT Koch Institute for Integrative Cancer Research, July 15. This lecture is now archived.
 
High–throughput, combinatorial approaches have revolutionized small-molecule drug discovery.  Dan Anderson will describe his work on the combinatorial development of nanoparticulate, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized, formulated, and screened for their ability to deliver macromolecular payloads inside of cells.  These nanoformulations facilitate in vivo delivery, enabling gene suppression with small-interfering RNA, gene expression with messenger RNA, or permanent genetic editing using the CRISPR/Cas9 system.  Formulations have been developed with in vivo efficacy and show potential therapeutic applications for a range of different diseases.  This lecture will focus on the application of these formulations toward controlling the immune system and in particular as vaccines for infectious disease.
 
Lessons Learned: Management and Treatment during COVID-19 Pandemic
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Lessons Learned: Management and Treatment during COVID-19 Pandemic," by Judith A. Aberg, M.D., chief of Infectious Diseases, Icahn School of Medicine at Mount Sinai, and a member of the panel developing NIH COVID-19 Treatment Guidelines, July 8. This lecture is now archived.
 
Dr. Aberg will briefly discuss what is new in the pathogenesis of SARS-CoV-2 and how this affected the decision-making processes on the management and treatment of SARS-CoV-2 infection during the COVID-19 pandemic in New York City. Even in the absence of data and insufficient knowledge of what may or may not work, the Mount Sinai Health System created treatment guidelines that were updated frequently based on physicians' observations and information gathered from multiple disciplines across the system. Dr. Aberg will present a few lessons learned that affected the quality-of-care of patients. The majority of her talk will focus on how clinical observations at the Mount Sinai Health System and how social media and knowledge imparted from colleagues across the globe influenced clinical decision making. Dr. Aberg will close the talk with a summary of how she and her colleagues are better prepared for the future, the knowledge they have gained, and the potential therapeutic options currently under investigation.
 
High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria," by Dorothee von Laer, M.D., Medical University of Innsbruck, July 1. This lecture is now archived.
 
In early March 2020, a SARS-CoV-2 outbreak at a ski resort in Ischgl, Austria, initiated the spread of SARS-CoV-2 throughout Austria and Northern Europe. Thousands of infections can be traced back to Ischgl. In a recent study by Medical University of Innsbruck investigators, 42.4 percent of those living in Ischgl were shown to be carrying the new coronavirus antibodies, indicating they had been infected in the COVID-19 pandemic. Between April 21 and 27, a cross-sectional epidemiologic study targeting the full population of Ischgl (n= app. 1,867), of which 79 percent could be included (n=1473), was performed. For each individual, the study involved a SARS-CoV-2 PCR test for the virus, antibody testing, and a questionnaire. In addition, the SARS-CoV-2 PCR+ cases reported to the authorities were included. The seroprevalence was 42 percent and individuals under 18 showed a significantly lower seroprevalence (27 percent) than adults (45 percent). However, only 105 study participants remembered if they had a previous positive PCR result. The clinical course was generally mild and only two individuals in Ischgl had died from infection corresponding to an infection fatality rate (IFR) of 0.26 percent. In the first week of April, a public screening in Ischgl had found 19 percent of the population to be PCR+. However, only 8 (0.5 percent) individuals were newly diagnosed to be infected with SARS-CoV-2 during the study conducted 2-3 weeks later.  Ischgl was hit early and hard by SARS-CoV-2, which led to a high local seroprevalence of 42 percent, that was lower in individuals below the age of 18 than in adults with a low IFR. As nonpharmaceutical interventions (e.g. social distancing, mask wearing) had already reduced virus spread, mathematical models conclude that the high seroprevalence significantly contributed to the drastic decline of new infections during April.
 
Covid-19: A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing," by Nevan Krogan, Ph.D., University of California, San Francisco, June 24. This lecture is now archived.
 
Efforts to develop antiviral drugs versus COVID-19 or vaccines for its prevention have been hampered by limited knowledge of the molecular details of SARS-CoV-2, the virus that causes COVID-19. This webinar will describe Nevan Krogan's efforts to address this challenge. He and his lab expressed 26 of the 29 SARS-CoV-2 proteins in human cells and are using affinity–purification mass spectrometry to identify the human proteins physically associated with each. Among 332 high–confidence SARS-CoV-2-human protein–protein interactions, Krogan's lab has identified 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Within a subset of these, Krogan's lab has used several viral assays to identify two sets of pharmacological agents that displayed antiviral activity.
 
COVID-19: The Australian Experience and a Perspective Through a SARS-1 Lens

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19: the Australian Experience and a Perspective Through a SARS-1 Lens," by Kanta Subbarao, M.B.B.S., Director of the WHO Collaborating Centre for Reference and Research on Influenza Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia, June 17. This lecture is now archived.
 
In a few short months, SARS-CoV-2 has swept through the world infecting more than 7 million people and causing more than 400,000 deaths.  However, the pandemic experience and response in different countries around the world has varied.  The peak of the outbreak has passed in Australia, with more than 7,000 cases and more than 100 deaths, but there is a real possibility of a second wave of infection. The viruses that caused the SARS outbreak of 2002/2003 and the current COVID-19 pandemic are related betacoronaviruses.  Experience with SARS-1 provides some insights into the COVID-19 pandemic.  In this seminar, Dr. Subbarao will discuss the Australian COVID-19 experience and response and will look back on SARS-1 vaccine development for important lessons that can inform SARS-CoV-2 vaccine design, testing, and implementation.
 
Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas," by Aviv Regev, Ph.D., Broad Institute, June 3. This lecture is now archived.
 
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Single-cell analysis of healthy- and SARS-CoV-2-infected tissues offers a unique lens to identify these mechanisms. In an international integrated analysis of the Human Cell Atlas Lung Biological Network--which spans more than 100 single-cell and single-nucleus RNA-Seq datasets previously collected from healthy tissues and includes many previously unpublished studies--we identified the cell types throughout the body most likely to be susceptible to viral entry. In line with epidemiological observations, we also identified increased expression of key mediators of SARS-CoV-2 cellular entry associated with increasing age, male gender, and smoking. In addition, we identified a gene program shared by these cells that includes genes that may mediate viral entry and play key immune roles, such as IL6 and its receptor and co-receptor, IL1R; TNF-response pathways; and complement genes. Following these studies, as the pandemic reached our local Boston community, we have adapted existing sample-processing pipelines with our collaborators in Boston hospitals and are using single-cell and spatial genomics techniques to procure, process, and analyze blood and post-mortem tissue from COVID-19 patients. We are using these pipelines to examine the tissue and immune cellular response to COVID-19, particularly to understand the factors underlying its severity in some individuals and will share our preliminary results.
 
Structural Studies of Coronavirus Fusion Glycoproteins
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Structural Studies of Coronavirus Fusion Glycoproteins," by David Veesler, Ph.D., Assistant Professor of Biochemistry, University of Washington, May 27. This lecture is now archived.
 
SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19 pandemic. Coronavirus spike (S) glycoprotein trimers promote the virus’s entry into cells and are the main targets of the humoral immune response. We demonstrated that Angiotensin-converting enzyme 2 (ACE2) is a functional entry receptor for this novel coronavirus and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to ACE2, which correlates with the efficient spread of SARS-CoV-2 among humans. We used cryo-electron microscopy to determine the structures of the SARS-CoV-2 S ectodomain trimer, demonstrating spontaneous opening of the receptor-binding domain, and providing a blueprint for the design of vaccines and inhibitors of viral entry. SARS-CoV S murine polyclonal sera potently inhibited SARS-CoV-2 S-mediated entry into target cells, indicating that vaccination can elicit cross-neutralizing antibodies targeting conserved S epitopes. We subsequently isolated a monoclonal antibody (termed S309) from the memory B cells of an individual who recovered from SARS-CoV in 2003 and showed that S309 potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2. Using cryo-electron microscopy and binding assays, we show that S309 recognizes a receptor-binding domain--glycan-containing epitope, which is conserved within the sarbecovirus subgenus--without competing with receptor attachment. Antibody cocktails including S309 further enhanced SARS-CoV-2 neutralization and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease.
 
Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic," by Tara N. Palmore, M.D., Hospital Epidemiologist, NIH Clinical Center, May 20. This lecture is now archived.
 
Dr. Palmore will discuss infection control related to COVID-19.  Dr. Palmore began her career at the NIH as a staff clinician in the NIAID Laboratory of Clinical Infectious Diseases.  She became deputy hospital epidemiologist in the NIH Clinical Center in 2007 and became hospital epidemiologist in 2014.  As hospital epidemiologist, Dr. Palmore aims to optimize patient safety through prevention of hospital-acquired infections.  Her research interests include modes of nosocomial transmission of multidrug-resistant bacteria, Clostridium difficile and antimicrobial stewardship.
 
Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences," by Lori Dodd, Ph.D., Mathematical Statistician, Biostatistics Research Branch, NIAID Division of Clinical Research, May 13. This lecture is now archived.
 
Designing and implementing clinical trials for novel infectious disease treatments brings many challenges, especially during a rapidly evolving pandemic.  A new disease brings uncertainties arising from an imperfect understanding about illness, limited information about proposed countermeasures, and complexities in measuring relevant patient outcomes.  A pandemic adds an overloaded medical system with limited resources for research, heightened pressure to find cures quickly, and unpredictability about potential case numbers.  I will discuss issues related to designing and conducting treatment trials in outbreaks of Ebola and COVID based on my experience with three studies: Prevail II (the West African Ebola virus disease study of ZMapp), PALM (the Democratic Republic of the Congo Ebola virus disease study of ZMapp, mAb114, REGN-EB3 and remdesivir) and ACTT-1 (the multinational, platform COVID-19 study of remdesivir vs placebo.
 
Animal Models for COVID-19: A Critical Component of the Response to the Pandemic
 
The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Animal Models for COVID-19: A Critical Component of the Response to the Pandemic," by Emmie de Wit, Ph.D., chief of the NIAID Molecular Pathogenesis Unit, May 6. This lecture is now archived at https://videocast.nih.gov/watch=37432.
 
We are learning more about different aspects of COVID-19 disease manifestations on an almost daily basis. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models where repeated sampling and tissue collection is possible. Non-human primate models that recapitulate aspects of human disease are essential for our understanding of the pathogenic processes involved in severe respiratory disease and for the development of medical countermeasures such as vaccines and antivirals. We have developed a rhesus macaque model that recapitulates COVID-19 with regard to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions, and seroconversion. These data allow us to bridge between the rhesus macaques model and the disease observed in humans and to use this animal model to assess the efficacy of medical countermeasures. While a large number of investigational, approved, and repurposed drugs have been suggested for the treatment of COVID-19, preclinical data from animal models can guide a more focused search for effective treatments in humans by ruling out treatments that have no proven efficacy in vivo. Remdesivir (GS-5734) is a nucleotide analog prodrug with broad antiviral activity, including against coronaviruses, that is currently being investigated in COVID-19 clinical trials worldwide. The therapeutic efficacy of remdesivir was tested in our rhesus macaque model of COVID-19. Remdesivir treatment initiated early during infection had a clear clinical benefit in SARS-CoV-2-infected rhesus macaques.
 
COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2

Please join us for "COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2," by Karen Frank, M.D., Ph.D., Chief, Department of Laboratory Medicine, NIH Clinical Center, April 29. This lecture is now archived at https://videocast.nih.gov/watch=37377.
 
Since the COVID-19 pandemic began, detection of individuals infected with SARS-CoV-2, followed by contact tracing and quarantine, has been critical to slow the spread of disease. After discovery, the coronavirus was sequenced extremely rapidly, and multiple RT-PCR assays were quickly developed, and the details shared for use by laboratories worldwide. The molecular assays have excellent performance characteristics with very high sensitivity and specificity. In the United States, the assay designed by the CDC and granted Emergency Use Authorization by the FDA was adopted across the country. In addition, many academic laboratories and commercial manufacturers designed different versions of SARS-CoV-2 tests. The unprecedented need for testing resulted in a severe shortage of all reagents and supplies including collection swabs, transport media, extraction kits, and RT-PCR enzyme mixtures. Creative solutions such as the 3D printing of swabs resulted. A number of studies are underway to determine which specimens (nasopharyngeal, nasal, oropharyngeal, or saliva) are acceptable for testing. Studies that examine viral load from exposure to the end of the disease course are critical for characterizing this sometimes-fatal disease as we work to find treatments. As we develop an algorithm to move out of "stay-at-home lockdown," there is a scramble to develop a high-quality serological assay that would detect neutralizing antibodies.
 
Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness
 
Please join us for "Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness," by Barney S. Graham, M.D., Ph.D., deputy director of the NIAID Vaccine Research Center, April 22. This lecture is now archived at https://videocast.nih.gov/watch=36377
 
The prototype pathogen approach for pandemic preparedness has been applied to the Middle East respiratory syndrome coronavirus (MERS CoV) over the last seven years.  It was informed by structure-based immunogen-design concepts established for respiratory syncytial virus fusion (RSV F) subunit vaccines, and focused on solving coronavirus spike structures, defining mechanisms of CoV neutralization, and evaluating MERS CoV vaccine candidates in collaboration with a commercial mRNA manufacturer.  Prior spike protein engineering experience resulted in rapid sequence selection and using the mRNA manufacturing platform provided rapid Good Manufacturing Practice (GMP) production a COVID-19 mRNA vaccine in record time.  This candidate was tested in mice in approximately 25 days and humans in approximately 65 days from the time the sequence was released.  Clinical and nonclinical evaluation are now proceeding in parallel with hopes to begin efficacy testing before next winter.  The proactive preparation not only facilitated vaccine development but provided a stabilized spike protein reagent that is supporting the development of serological assays.
 
The Biomedical Research Response to COVID-19: A View from NIAID
 
Please join us for a special remote lecture, "The Biomedical Research Response to COVID-19: A View from NIAID," by Hilary D.  Marston, M.D., M.P.H., on Wednesday, April 15. This lecture is now archived.
 
NIAID has a long-standing dual mandate to maintain a robust portfolio of research in its key focus areas and to respond to emerging and re-emerging infectious diseases (EIDs).  With this mandate, NIAID has also sought to improve EID-response preparedness, working in partnership with other U.S.  government research entities, industry, academia, and international public-health organizations.  This preparedness planning helped the institute respond rapidly to COVID-19.  NIAID tapped existing coronavirus expertise and other assets to stand up research programs spanning basic virology and immunology through to countermeasure development (diagnostics, therapeutics, and vaccines).  As the outbreak has expanded, so too has the NIAID research program and the scope of the problems it seeks to solve.  As the COVID-19 pandemic has grown, it has become increasingly clear that the biomedical research response must draw upon the collective expertise of many NIH Institutes and Centers. 

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  • How People Learn, Volumes I and II
  • Attribution of Extreme Weather Events in the Context of Climate Change
  • Barriers and Opportunities for 2-year and 4-year STEM Degrees
  • Science, Evolution, and Creationism

Virtual Keystone Symposia
offers free, on-demand and live-streaming of scientific content, highlighting today's breakthroughs in basic research, translational impacts and global health topics. Videos are available on demand after the live sessions.

NIGMS Offerings
 
NIGMS Webinar Series 
 
NIGMS is hosting a series of webinars that may be of interest to you/your trainees. The next webinar is Monday, May 11 at 4 PM ET and focuses on "Infectious Disease Modeling Research and the MIDAS Network."  Others topics include "Virtual Teaching and Learning," "Cryo-EM: Present and Future," "Computational Biology and Biomedical Data Science", and "Culturally Aware Practices for Virtual Mentoring, Teaching, and Learning."
 
See the full list here: 
https://www.nigms.nih.gov/News/meetings/Pages/webinars-for-trainees.aspx
Log in information will be available under the "date" column in the table of topics and speakers.
 
NIGMS Virtual Learning Resources for Scientists at All Career Stages
To assist with virtual learning during the COVID-19 pandemic, NIGMS has assembled valuable resources to support its trainee and educator communities. These resources apply to all levels, ranging from community college students to faculty.
 
  • Clearinghouse for Training Modules to Enhance Data Reproducibility
    A variety of free training modules, workshops, and online courses aimed at enhancing rigor and reproducibility in research.
  • iBiology 
    A collection of high-quality, free online videos of scientists talking about their research, career paths, and related topics. Several complete courses are also available in areas including experimental design, microscopy, and image analysis. iBiology also has resources for flipped-classroom teaching.
  • National Research Mentoring Network 
    A free, web-based platform designed to help undergraduates, graduate students, and postdocs connect professionally through online mentoring and networking activities.

NIAID Bioinformatics and Computational Biosciences Branch Presents NIAID BEST: Training Webinars in Times of Teleworking
 
Are your teleworking days giving you some additional flexibility in your schedule? If so, this could be a great opportunity to learn or strengthen your bioinformatics and computational skills! The NIAID Bioinformatics and Computational Biosciences Branch (BCBB) is launching the Bioinformatics Education Support Training (NIAD BEST) program to offer free webinars for all NIH employees over the next few weeks.
 
In summer 2020, the seminars included:
  • Publishing to NCBI SRA the Easy Way Using METAGENOTE
  • Customizing Your Graphs Using GraphPad Prism 8
  • Practical Training on GraphPad Prism for Statistical Testing - Parts I & II
  • Introduction to UNIX
  • Finding Master Genes Through Gene Regulatory Network Analysis
  • Studying the Microbiome Using the Nephele Web Platform
  • Molecular Visualization with Chimera
  • Preparing and Submitting Protein Structures to the NIAID 3D Printing Service
All webinars were recorded and posted for self-paced learning at https://bioinformatics.niaid.nih.gov/resources.
Contact us at bioinformatics@niaid.nih.gov for questions or suggestions for additional topics.

Ethical and Regulatory Aspects Of Clinical Research
 
Register for the course Ethical and Regulatory Aspects of Clinical Research. This 7-week course covers essential topics in the ethics of clinical research and is designed for researchers and research teams, clinical staff, IRB members, and others interested in the ethics of clinical research. Presentations are given by experts from both within and outside the NIH. 
The course runs from 22 September 2021 – 3 November 2021 and will be broadcast live. The course meets Wednesday mornings from 8:30 –11:30 am Eastern. In addition to lectures, we will host conversations with experts and engage in case discussions.  Due to the uncertainty about COVID the course will be delivered virtually this year.
 
Information about the course including the syllabus are available at https://bioethics.nih.gov/courses/ethical-regulatory-aspects.shtml    
 
This course is available to anyone via live video-cast at http://videocast.nih.gov. There is no charge.  Videos from last year’s course as well as many years prior are posted here: https://videocast.nih.gov/PastEvents?c=22

Translational Research in Clinical Oncology
 
The NCI Center for Cancer Training is pleased to announce that the Translational Research in Clinical Oncology (TRACO) course will be offered virtually from September 7, 2021 to November 29, 2021.  The TRACO course is designed to provide an overview of the general principles of cancer biology and treatment, genomics, precision medicine, mechanisms of resistance, use of preclinical models and identification of novel molecular targets.  Participants will have an opportunity to learn new information, glimpse into the future developments of translational research in clinical oncology and see leaders in cancer research.  NIH Postdoctoral and Clinical Fellows are encouraged to participate.
 
The TRACO course usually occurs on Monday afternoons from 4:00-6:00 p.m.  Due to the pandemic, this year's course will be held by WebEx.  Registration, at no cost, is available at http://www.cancer.gov/grants-training/training/resources-trainees/courses-fellowships/translational-research-clinical-oncology and is due by Sept. 7, 2021.  The registration limit is 200 and the course schedule is shown below. 
 
Sept. 7: Introduction by T. Moody; Cervical Cancer by J. Schiller. 
Sept. 13: Global Health and Cancer by S. Gopal; Covid-19 and Cancer by W. Dahut.
Sept. 20: Ovarian Cancer by C. Annunziata; Immune Checkpoints by S. Goff. 
Sept. 27: Small Molecules by A. Simeonov; Clinical Trials by J. Smith. 
Oct. 4: Radiation Oncology by E. Nichols; Tumor Imaging by P. Choyke. 
Oct. 12: Prostate Cancer by R. Madan; Cannabis and Cancer by A. Freedman.
Oct. 18: Genomics by J. Wei; CAR-T cells by J. Brudno. 
Oct. 25: Breast Cancer by F. Zia; SCLC by H. Chen.
Nov. 1: KRAS by J. Luo; Brain Cancer by W. Timmer. 
Nov. 8: NSCLC by E. Szabo; HIV by F. Maldarelli.
Nov. 15: Epigenetics by M. Verma; Case reports by O. Olaku. 
Nov. 22: Precision Medicine by C. Harris: Topoisomerase by Y Pommier. 
Nov. 29: Pancreatic Cancer by P. Hussain; Nanotechnology by M. Dobrovolskaia.
 
All lectures will be recorded and archived.  Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Dr. T. Moody at 9609 Medical Ctr. Dr., Rm. 2W340, moodyt@nih.gov, 240-276-7785 and/or the Federal Relay (1-800-877-8339).

Advancing NIH Research on The Health Of Women: A 2021 Conference
 
On behalf of the NIH Office of Research on Women’s Health (ORWH) and in accordance with the efforts outlined in the new NIH-Wide Strategic Plan, I want to bring to your attention an opportunity to provide comments to help inform an upcoming virtual NIH event, “Advancing NIH Research on the Health of Women: A 2021 Conference,” on October 20, 2021. ORWH, in conjunction with the Advisory Committee on Research on Women’s Health, will host this conference in response to a congressional request asking NIH to review its research efforts related to the following:
  • Rising maternal morbidity and mortality rates
  • Increasing rates of chronic debilitating conditions in women
  • Stagnant cervical cancer survival rates
To participate in the conference, please register at https://bit.ly/3eKSeHC.
In preparation for the conference, the open comment period will assist in identifying gaps in research and clinical practice pertaining to the topics mentioned above. More information on this comment period can be found here or in this Federal Register notice (FRN). We would appreciate your support by responding to the request for comments and sharing this FRN with your network. Comments will be accepted through September 15, 2021 and must be submitted by email to WHCC@od.nih.gov. Sample social media messages can be found here.

Molecular Mechanisms and Evolution Of Vocal Learning
 
Please join the NIH Office of Behavioral and Social Sciences Research (OBSSR) for a virtual presentation by Erich D. Jarvis, Ph.D., Rockefeller University, on September 14, from 2:00 to 3:00 pm ET.
 
Register for this virtual event: https://bit.ly/3guwbpq.
 
Presentation Overview:
Vocal learning is the most critical behavior for spoken language. It has evolved multiple independent times among mammals and birds. Remarkably, although all vocal learning species are distantly related and have closer relatives that are non-vocal learners, humans and the vocal learning birds have evolved convergent forebrain pathways that control vocal learning. We used comparative genomics and transcriptomics to discover convergent changes in multiple genes in song learning pathways in birds and speech pathways in humans. The vocal learning brain pathways have convergent specialized changes in genes that control connectivity, neuroprotection, and synaptic plasticity. We have found that specialized regulation is associated with convergent accelerated regions in the genomes of these species, which in turn have differential epigenetic availability in enhancer regions of some of the genes, inside the neurons of the vocal learning brain regions. To explain these findings, we propose a motor theory of vocal learning origin, in which brain pathways for vocal learning evolved by brain pathway duplication of an ancestral motor learning pathway, using mostly the same genes, but with some divergences in gene regulation via sequence and epigenetic changes, that control divergent connectivity and other functions.
 
Presenter Biography:
Erich D. Jarvis, Ph.D.
Professor and Head of the Laboratory of Neurogenetics of Language, Rockefeller University, Investigator, Howard Hughes Medical Institute.
 
Individuals who need reasonable accommodation to participate in this event should contact Erica Moore, erica.moore2@nih.gov, 301-594-4392, and/or the Federal Relay at 1-800-877-8339.

NIMH Director’s Innovation Speaker Series
 
Title: Developmental Cognitive Neuroscience in the Era of Big Data
 
Speaker: Damien Fair PA-C, Ph.D.
 
Date: September 9, 2021, 3:00-4:00 PM ET
 
Zoom registration required: ATTENDEE REGISTRATION LINK https://zoom.us/webinar/register/WN_YZhJpThlSmCUQKdwWX1QXQ
Webinar ID: 972 2572 5678
 
Please join the National Institute of Mental Health (NIMH) on September 9, 2021, for its annual Director’s Innovation Speaker Series, dedicated to innovation, invention, and scientific discovery.
 
The guest speaker is Damien Fair PA-C, Ph.D., a founding co-director of the Masonic Institute for the Developing Brain and a professor in the Department of Pediatrics at the University of Minnesota Medical School. Dr. Fair’s research focuses on mechanisms and principles underlying child and adolescent brain development. Most of his work uses functional MRI and resting-state functional connectivity MRI to assess typical and atypical populations.
 
The field of cognitive neuroscience, particularly developmental cognitive neuroscience, continues to evolve in ways that its founders may not have recognized nearly 50 years ago. The past decade has witnessed the emergence of a series of openly available, large-scale (N > 1000) neuroimaging data resources, spanning a range of populations and experimental designs. Over the same period, the growth of small N studies (N ~ 1-10) with massive amounts of within-subject imaging (>10 hrs) and phenotyping have also emerged. These “big data” areas have brought about new concepts and technologies but have also highlighted new challenges and pitfalls in the field. On the one hand, these growing pains revealed the promise of the work for understanding complex human brain function and its translational potential. On the other hand, it exposed practices slowing progress.
 
Modern-day efforts toward characterizing correspondence of complex behavioral phenotypes to networks and systems in the brain require new sample collection strategies, study designs, and analytic strategies. During his talk, Dr. Fair will highlight positive developments in functional neuroimaging with the potential to put the field on a more solid footing moving forward and realize the translational potential of these non-invasive methodologies.
 
More information is available on the NIMH website at https://www.nimh.nih.gov/news/innovation-speaker-series/.   
 
For questions, please email InnovationSpeakers@mail.nih.gov.
 
Sign Language Interpreters will be provided. Individuals with disabilities who need a reasonable accommodation to participate in this program should contact the Federal Relay (1-800-877-8339).

Complementary and Integrative Medicine

The NCI Center for Cancer Training is pleased to announce the Complementary and Integrative Medicine course (IM), 2021 Fall Term (September 15 to December 2).
 
This course is designed for NIH fellows who want to enhance and broaden their knowledge of evidence-based comprehensive integrative healthcare to improve the lives of patients, including those with cancer. Topics will be presented with research evidence, followed by clinical scenarios. Students will have the opportunity to better understand the current state of the science of each subject, as well as be introduced to cutting-edge advances in medical research. 
 
There will be two-hour sessions each day with two 45 min lectures. It will usually occur on Thursday, 3-5 p.m., except September 15 at 10 a.m.-12 p.m. Due to the pandemic, the course sessions will be conducted via WebEx ONLY.  Speakers will be representative of experts in their field, domestic and international, drawn broadly from government, academia, and the integrative medicine community.  NIH staff, Postdoctoral and Clinical fellows are encouraged to participate. The lectures are open to the public.
 
 
COURSE SCHEDULE AND CURRICULUM
 
September 15: Traditional Chinese Medicine: Philosophy & Research by W. Lu; Acupuncture by H. Langevin.
September 30: Nutrition, Physical Activity and Cancer by D. Abrams.
October 14: Light Therapy and Circadian Clock by U. Albrecht; Circadian Clock and Cancer by B. Altman.
October 28: Tai Chi and Qigong: Practice & Research by Y. Yang; Physical Activity (NIH Common Fund) by C. Nierras.
November 4: Music Therapy by A. Pantelyat; Natural Product by C. Paller.
November 18: Exercise and Cancer by L. Jones; Mindfulness and COVID-19 by R. Ameli.
December 2: Cannabinoid and Immune System by A. Oláh; Integrative Medicine Education in Acupuncture Training by L. Lao.
 
Trans-NIH Integrative Medicine Training Course Committee.
  1. Xi, Ph.D., IM Course Director; A. Berger, M.D.; T. Moody, Ph.D.; D. Shurtleff, Ph.D.; and F. Zia, M.D.
Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this course should contact Dr. Terry Moody, moodyt@nih.gov, 240-276-7785, or Dr. Dan Xi, xida@mail.nih.gov, 240-276-6143, and/or the Federal Relay (1-800-877-8339).

Racial and Ethnic Diversity in the United States
 
Title: “Racial and Ethnic Diversity in the United States: Highlights from the 2020 Census”
Date: Tuesday, September 14, 2021
Time: 10:30–11:30 a.m. ET
 

Speaker: Nicholas A. Jones, Director and Senior Advisor of Race and Ethnic Research and Outreach, Population Division, U.S. Census Bureau

Link: https://nih.webex.com/nih/onstage/g.php?MTID=e896c3646f128c861f64e3ccfe84ad938

Please join the Health Disparities Interest Group and the NIMHD Division of Intramural Research for a seminar by Mr. Nicholas A. Jones, Director and Senior Advisor of Race and Ethnic Research and Outreach, Population Division, U.S. Census Bureau.

Mr. Jones began his career at the Census Bureau in 2000 as an analyst in the Racial Statistics Branch. His research helped shed light on race reporting patterns and the demographic characteristics of children in interracial families. As an analyst, Mr. Jones authored numerous reports and presentations and became a renowned expert on the multiracial population and the racial and ethnic diversity of the United States.

Mr. Jones has presented his work at numerous academic conferences and professional meetings and discussed race and ethnicity trends with a wide variety of media outlets. He was honored by American Demographics magazine as one of the top young demographers for his research on the multiracial population and earned two Department of Commerce Bronze Medal Awards for the review and analysis of race data from the 2000 and 2010 Censuses.

Mr. Jones received a master’s degree in sociology from the University of Michigan and a bachelor’s degree in sociology and anthropology from St. Mary’s College of Maryland.

For lecture questions, please email Dr. Kelvin Choi at Kelvin.Choi@nih.gov.

Individuals who need reasonable accommodations to participate, please contact Edgar Dews at Edgar.Dews@nih.gov or the Federal Relay at 1-800-877-8339.


Methodological Approaches for Whole Person Research
 
Please join us for “Methodological Approaches for Whole Person Research,” which represents a trans–National Institutes of Health (NIH) effort. Ten NIH institutes, centers, and offices were involved in planning this event (see list of collaborators below).
 
Methodological Approaches for Whole Person Research (September 29–30, 2021)
11:30 a.m.–5:30 p.m. ET
 
View the agenda and register at https://bit.ly/3zjYAF2.
This free workshop will be live-streamed and archived online.
 
The National Center for Complementary and Integrative Health's new strategic plan defines whole person research as including three components:
 
  1. Exploring the fundamental science of interconnected systems
  2. Investigating multicomponent interventions or therapeutic systems
  3. Examining the impact of these interventions on multisystem or multiorgan outcomes
 
The “Methodological Approaches for Whole Person Research” workshop will provide examples of research studies in these three areas from diverse fields. The workshop will also identify opportunities for this type of research in complementary and integrative health and discuss:
 
  • Relevant study designs
  • Statistical methods
  • Computational approaches.
Whether you are a scientist in the fields of system/computational biology or complex clinical trials, or a complementary and integrative health provider or researcher, whole person researcher, or just interested in the topic, we welcome you to register and participate.
 
NIH Collaborators:
 
National Center for Complementary and Integrative Health; National Institute on Aging; National Institute on Minority Health and Health Disparities; National Institute of Nursing Research; National Institute of Dental and Craniofacial Research; Fogarty International Center; Office of Research on Women’s Health; Office of Behavioral and Social Sciences Research; Office of Disease Prevention; Office of Nutrition Research
 
Accommodations:
To request sign language interpretation or other reasonable accommodations to participate, contact the NCCIH Clearinghouse at info@nccih.nih.gov or 1-888-644-6226 or the Federal Relay Service (1-800-877-8339).
Disabilities in Science
 
 
2021 Annual Interagency Accessibility Forum
 

September 20, 2021 - Please join us for the virtual 2021 Annual Interagency Accessibility Forum this October 12-14.

Attendees of this year’s IAAF will hear presentations and panel discussions that will focus on accessibility as a foundation for inclusion, diversity, and equity within the federal government. In addition, the forum will include virtual exhibitions by accessibility consultants and IT companies with accessibility products and services that support those with disabilities.

SAVE YOUR SEAT
When: October 12-14, 2021; from 12:00 PM - 4:00 PM ET
Where: Virtual - Note that the event will be recorded for reuse and archiving
Who: There is something for everyone - contracting officials, business analysts, project managers, developers, testers, content creators, Section 508 Program Managers, and members of agency management and leadership
How: Register Today!

For full event and registration information, visit Section508.gov/IAAF.
 
To rediscover keynote addresses and presentations from a range of presenters, panelists, and speakers over the years, visit the Interagency Accessibility Forum (IAAF) Archives.

The 2021 Interagency Accessibility Forum (IAAF) is sponsored by the Federal Chief Information Officer Council’s (Federal CIO Council) Accessibility Community of Practice (ACOP) and hosted by the Government-wide IT Accessibility Program from the Office of Government-wide Policy (OGP) of the General Services Administration (GSA), Department of Health and Human Services (HHS), Department of Labor (DOL), and Merit Service Protection Board (MSPB), in partnership with other federal agencies.

National Disability Employment Awareness Month (NDEAM)

USDA TARGET Center Commemorates the Contributions of Individuals with Disabilities at USDA and America's Workplaces Lectures: https://www.targetcenter.dm.usda.gov/content/2021-ndeam

ODEP News Brief (including articles and talks about disabilities): https://www.dol.gov/agencies/odep/publications/news-brief?utm_source=govdelivery&utm_medium=email&utm_campaign=ODEP_Newsletter_footer_web-view

Celebrate NDEAM 2021 and the 20th Anniversary of the Office of Disability Employment Policy: https://www.eventbrite.com/e/celebrate-national-disability-employment-awareness-month-2021-tickets-186087802627

The Accessibility of Motherhood - A Workshop on Disability and Pregnancy

November 1-3, 2021
12:00 p.m. – 1:30 p.m. ET.

Although existing research documents that women with disabilities experience inequities with reproductive health and quality of life compared to women without disabilities, the research remains nascent and incomplete. Further evidence is needed to expose and support the actions that improve equity for women with disabilities. The goal of this three-day interactive workshop of stakeholders is to identify priority areas of focus and create momentum for the research agenda needed to address inequities in pregnancy outcomes and related health care among women with disabilities, especially the inequities experienced by those from underserved and underrepresented populations.

Workshop Registration closes October 25. Space is limited.

The workshops will include real-time captioning and remote video American Sign Language interpreting. Presentations slides will be emailed to attendees prior to the event. If you need other disability-related accommodations, please specify your needs on the registration form. If you have any difficulties registering, please email events@1sourceevents.com.

ACL/NIH Disability and Pregnancy: Research from NIDILRR and NICHD: https://acl.gov/sites/default/files/Aging%20and%20Disability%20in%20America/ACL-NIH-Issue-Brief-Disability-Pregnancy-2021-508compliant_AR%20corrections%20and%20ES.docx


 

Building your Personal Brand

Sponsored by the ASBMB Education and Professional Development Committee

What are personal brands, and how can scientists put them to work for their careers? In this interactive workshop, participants will learn about personal brands, create their own personal statements and identify ways to build their personal brands. To make the most of this session, bring paper and pen to write down your ideas and connect with other attendees about theirs.

Watch here: https://zoom.us/meeting/register/tJEoce-orzwpG9SfpE-eHROF4DIUhVs0Ngpg

This free workshop is part of the ASBMB's activities celebrating National Postdoc Appreciation Week.


 

Women Leaders in Academic Research

Invited monthly lecture series highlighting & honoring women leaders in academic research, especially related disciplines of Interventional Radiology, Biomedical Engineering, Radiology, Imaging Sciences, Data Science, & Image-Guided Oncology. The honorary lecture series was established by the NIH Center for Interventional Oncology as a small effort to help counter the under-representation of women in academic research & the impact of gender disparity & implicit bias on role modeling and mentoring. Monthly topics are open-ended & are geared towards highlighting successful female or other under-represented academic leaders, as role models for trainees.

Re-Thinking Mentoring:  Perspectives from a Biomedical Engineer - Jenna Mueller
 
Building New Roads: the importance of tenacity, resilience, and mentorship - Isabel Newton
 
Leading the Way to a Modern Data Ecosystem: Stories of Women (and Men) Making an Impact in Data Science at NIH – Susan Gregurick
 
Triple Threat of Teaching, Research, & Patient Care: Easy as 1-2-3 – Sarah White
 
Team Science: An IR’s Adventures in Academic Medicine- Alda Tam
 
Keep Calm and Break Glass: The Gender Equity Imperative – Carolyn Meltzer

STRIVE

NICHD launched STRIVE to improve equity, diversity, and inclusion (EDI) in all aspects of its research and workforce.

Led by the Office of Health Equity, STRIVE aims to:

  • Reinforce EDI within NICHD’s workforce
  • Foster EDI in the broader scientific workforce and among trainees
  • Understand how to mitigate, through research, the root causes of health disparities that may result from structural racism and discrimination, and develop potential solutions to reduce or address these disparities

NICHD’s STRIVE complements broader NIH efforts to promote EDI in its workforce and among those who participate in and conduct its research. The NIH UNITE initiative seeks to further these goals while also working to eliminate structural racism.

For access to future and past talks, check out https://www.nichd.nih.gov/about/org/strive/engagement.


 

Clinical Center Grand Rounds

The NIH Clinical Center Grand Rounds, which is a weekly CME activity, aims to offer its audience a wide variety of topics from a diverse group of speakers to not only help them remain current on the latest advances in medicine but also assist them as they continue to grow professionally. All physicians, clinicians, biomedical researchers, nurses, and all other healthcare professionals within and outside the NIH community are welcome to attend.

The CME activity code will be posted at the beginning and end of the 12:00 pm lecture. If you need the code or have questions, email Rita Stevens, CME Administrator at rita.stevens@nih.gov. More information about how to get CMS credit can be found in the link below.

Current month's meetings: https://clinicalcenter.nih.gov/about/news/grcurrent.html

Older meetings: https://clinicalcenter.nih.gov/about/news/grandrounds/grounds.html


 

Effective Approaches to Fostering Faculty Gender Diversity, Equity, and Inclusion: Celebrating Progress

The Office of Research on Women’s Health (ORWH) invites you to attend a forum titled “Effective Approaches to Fostering Faculty Gender Diversity, Equity, and Inclusion: Celebrating Progress,” presented by NIH, in partnership with the American Association for the Advancement of Science’s (AAAS) STEMM Equity Achievement (SEA) Change initiative and in collaboration with the National Academies of Sciences, Engineering, and Medicine’s (NASEM) Committee on Women in Science, Engineering, and Medicine.

Event Details:

Tuesday, October 5, at 12:00 p.m.–5:00 p.m. (Eastern Time).

Registration: https://bit.ly/3BYk8ck.

Description:

The forum will feature opening remarks by the NIH Director and the ORWH Director, a presentation by leadership of the AAAS SEA Change initiative, and several panels, including one moderated by NASEM’s Director of Diversity, Equity, and Inclusion. The panels for the forum include:

Panel - Vision for Institutional Change.
Panel - Training for Inclusive, Equity-Minded Environments.
Panel - Reducing Barriers to Career Advancement.
Panel - Effective Tools for Assessing and Monitoring Outcomes.
 
Featured Speakers:
Francis S. Collins, M.D., Ph.D., NIH Director.
Janine Austin Clayton, M.D., FARVO, ORWH Director.
Sudip Parikh, Ph.D., CEO of AAAS.
Shirley Malcom, Ph.D., Senior Advisor to the CEO of AAAS and the Director of the AAAS SEA Change initiative.
Rita Colwell, Ph.D., Distinguished University Professor of Bioinformatics and Computational Biology at the University of Maryland.
Representatives from the prizewinning institutions.
Representatives from the AAAS SEA Change initiative.
 

Individuals with disabilities who need reasonable accommodations to participate in this event should contact Leika Inniss at leika.inniss@nih.gov, at 240-541-4764, and/or through the Federal Relay (800-877-8339).


 

National Work and Family Month

This October, NIH will again participate in National Work and Family Month with the theme “Taking Care of Your Personal Well-Being.” This year’s event is by far the most important due to the past 18 challenging months of the pandemic. We pivoted our priorities at the beginning of the pandemic and have not faltered in our response efforts to ensure that NIH continues to be the National Institutes of Hope. During this period, however, many of us have placed our own well-being on hold.  Today, I am asking you to pause and “reboot” yourself by engaging in some very important activities. 

The Office of Research Services (ORS) and the Office of Human Resources (OHR) have outdone themselves this year as they once again partnered to provide over 70 archived and live events and work-life and well-being resources. I encourage everyone—federal employees, trainees, fellows and contractors—to explore and rediscover how to start taking care of yourself this month, but also throughout the year.

With sincere appreciation for all you do to support the NIH mission,
Francis S. Collins, M.D., Ph.D.
NIH Director
 

The Role for Feasible and Sustainable Interventions in Reducing Health Disparities

Date: Tuesday, October 12, 2021
Time: 10:30-11:30 a.m. ET
 
Speaker:
Margarita Alegría, Ph.D.
Chief, Disparities Research Unit
Massachusetts General Hospital
Professor, Departments of Medicine and Psychiatry Harvard Medical School
 

Location: https://videocast.nih.gov/watch=43957

Please join the NIMHD joint Health Disparities Interest Group and Division of Intramural Research lecture by Margarita Alegría, Ph.D., the chief of the Disparities Research Unit in the Mongan Institute at Massachusetts General Hospital, and a professor in the departments of medicine and psychiatry at Harvard Medical School.

Dr. Alegría has spent most of her career working on how to reduce health disparities for populations of color, immigrants, and linguistic minorities. Her research focuses on the improvement of health care services delivery for diverse racial and ethnic populations, conceptual and methodological issues with multicultural populations, and ways to bring the community’s perspective into the design and implementation of health services.

Dr. Alegría is currently the principal investigator of four NIH-funded research studies and has published more than 300 papers, editorials, intervention training manuals, and several book chapters. Prior to her work at Harvard, she was the director of the Center for Multicultural Mental Health Research at Cambridge Health Alliance and was previously the director of the Center for Evaluation and Sociomedical Research at the University of Puerto Rico.

Dr. Alegría was elected as a member of the National Academy of Medicine in acknowledgement of her scientific contributions to her field and has been the recipient of numerous prestigious awards. She obtained her B.A. in psychology from Georgetown University and her Ph.D. from Temple University.

For lecture questions, please email Dr. Kelvin Choi at Kelvin.Choi@nih.gov.

Individuals who need reasonable accommodation to participate, please contact Edgar Dews at Edgar.Dews@nih.gov.


 

Reading Between the Tweets: Social Technologies for Predicting and Changing Health Behavior

Tuesday, November 2, 2021

1-2 p.m. ET

No registration is required, and all are welcome. This online-only presentation will be broadcast live and archived at https://videocast.nih.gov/watch=43775 and on Facebook Live at https://www.facebook.com/nih.nccih. More information is available at https://bit.ly/IMLSDrYoung. For questions or requests concerning this lecture, please email info@nccih.nih.gov.              

Social technologies and their associated data are increasingly being used as tools in public health research and practice. Examples include social media, mobile apps, internet searches, and wearable sensors. More than half of the world uses social media sites to create, share, and discuss content—often personal and/or medical in nature. Dr. Young will discuss how social technologies and data (e.g., artificial intelligence and data science modeling) are being used to impact public health, and how researchers and health departments/agencies might apply them in public health surveillance/intervention efforts. He will also present his team’s research on how these tools can be employed to predict and change health behaviors as well as implementation-related issues. Studies to be discussed involve populations affected by HIV, mental health and substance use disorders, COVID-19, and car crashes.


 

PLOS Writing Center

We understand that the rapid publication of credible, peer-reviewed studies is essential to you as a researcher.

That’s why we have compiled an author resource hub, which includes resources and insight into best practices for every stage of the writing and publishing process. From tips on writing a great title, reporting statistics, or editing your work, the PLOS Writing Center has proven to be an invaluable resource for authors.

Explore the PLOS Writing Center and discover the resources that thousands of researchers use to maximize the impact of their work.

Explore the PLOS Writing Center


 

NIH Library Services

NOTE: Access to some of these resources may be limited to NIH personnel.
 
Earn Continuing Medical Education (CME) Credits with NIH Library Resources
Did you know that you can earn Continuing Medical Education (CME) credits through resources provided by the NIH Library? NIH staff can earn credits by researching clinical topics and completing evaluations and quizzes while using the resources below.
While on the NIH network, register for a free personal account in each of the following resources. Learn more about how to earn CME credits in each via the CME Information links. Then get started earning CMEs today.
 
Due to licensing, these resources are only available to NIH staff. New personal accounts must be set up while on the NIH network. For more information, contact Lisa Scanlon, lisa.scanlon@nih.gov

Enhance Your Data Science Skills with the SAGE Data Science Video Collection
Looking to enhance your data science skills this summer? Check out the SAGE Data Science, Big Data Analytics, and Digital Methods video collection made available by the NIH Library. Whether you are just starting out and want to learn how to program in R, or are an expert interested in brushing up on statistics or analytical tools and methods, this video collection can help. The collection is browsable, searchable, and, with an easy-to-create profile, users can save clips, playlists, and searches, and generate alerts. 

These online videos cover a wide range of innovative methods and best practices for data analysis, data visualization, and computational social science research. Over 3,200 videos comprising over 120 hours are available. Example topics include:
  • Programming (Python, R)
  • Data visualization
  • Data management
  • Data and text mining
  • Social media analytics
  • Statistical models and methods
  • Artificial intelligence, machine learning and deep learning
  • Networks and social network analysis
  • Spatial analysis
Check out the Data Science, Big Data Analytics, and Digital Methods video collection and start accelerating your data science training today.
 
Adobe Creative Cloud Software and Classes at the NIH Library (posted 6-10-21)
The NIH Library now provides remote access to the Adobe Creative Cloud suite of software, including After Effects, Illustrator, InDesign, Photoshop, and Premiere Pro. These industry-standard applications can be used for graphic design, video editing, and more. To use one of these applications through the Library’s remote access service, make a reservation. You will receive instructions for accessing the workspace along with the reservation confirmation. To ensure NIH Library staff are available to facilitate your online access, 48 hours advance notice is requested.
 
If you are new to these tools or want to brush up your skills, we also offer training on some of the most popular Creative Cloud applications. Join us for one of our upcoming classes—click on the links below to learn more and register.
Introduction to Adobe Photoshop
June 24, 10:00–11:30 am
Introduction to Adobe Illustrator
July 29, 10:00–11:30 am
Introduction to Adobe Premiere Pro
August 24, 1:00–2:00 pm
Intermediate Adobe Premiere Pro
September 29, 1:30–3:00 pm

For more information about remote access to Adobe Creative Cloud software or the upcoming classes, contact Alicia Lillich, alicia.lillich@nih.gov.
 
NIH Library Online Training Classes for September and October:
NIH Library classes are available. All classes are online via WebEx. Descriptions and registration are available through the links below.
 
Sep 1         Ingenuity Pathway Analysis (IPA)
Sep 7         Introduction to Scopus
Sep 9         Introduction to Scoping Reviews
Sep 23       Introduction to Taxonomies
Sep 27       Pathway Analysis
Sep 28       MATLAB for Open Science
 
Oct 5         Genome Browser
Oct 7         Introduction to EndNote Desktop
Oct 8         How to Write an Abstract
Oct 8         Introduction to PubMed
Oct 12       MATLAB with Python
Oct 14       Advanced PubMed
Oct 19       MetaCore Advanced Session
Oct 26       MATLAB for Excel Users
 
NIH Library Online Training Classes
 
The NIH Library Training Program is a premier provider of information and data management training for the NIH intramural research community. NIH Library classes are free, available to NIH and select HHS staff, and are currently being offered entirely online via WebEx. All sessions are taught by dedicated subject matter experts including NIH Library staff, guest instructors, and industry experts.
The NIH Library Training Program also offers on-demand, online tutorials to accommodate self-paced learning. For personalized instruction, schedule an individual or group consultation with one of our information experts.
NIH Library staff are available for ongoing support and help with research questions, specific training needs, or with follow-up questions after classes.

Full-text online journals, the library catalog, and information about Library resources and services are available on the Library's website: https://nihlibrary.nih.gov. For more information, contact the Library at 301-496-1080 or nihlibrary@nih.gov.
To stay up to date on NIH Library classes, events, resources, and services, subscribe to our e-news.
The NIH Library serves the information needs of NIH staff and select Department of Health and Human Services agencies. The NIH Library is part of the Office of Research Services in the Office of the Director.
 
Online Services, Training, and Resources from the NIH Library
 
The NIH Library is here to help you—online—with your teleworking information and research needs. This week, we are sharing top-level online services, training, and resources available from the NIH Library. In the coming weeks, we will feature additional online offerings under each of these main areas. 
 
Services
  • Ask A Question: contact us with your information questions
  • Get Help: use our “get help” forms to request materials, suggest a resource, get editing assistance, and more (most of our library services remain available during this time)
  • Find Your Librarian: contact your librarian for personalized assistance—each Institute or Center has their own dedicated informationist or specialized librarian
Training
  • Training classes: sign up for online classes in bioinformatics, databases, technology, writing and publishing, and other topics
  • Consultations: contact us to get personalized help with using our resources, conducting a systematic review, getting help with your bioinformatics questions, and more
  • Tutorials: check out our collection of on-demand, online tutorials which are ideal for self-paced learning 
Resources
  • Journals: access over 12,000 online current and historical journals, most with complete archives
  • eBooks: extend your research with our collection of over 160,000 scholarly eBooks
  • Databases: search over 50 reference databases including PubMed@NIH, Web of Science, Scopus, and UpToDate
NIH staff can access these online resources via the NIH VPN, or by logging in through the NIH Library’s remote access service. Eligible HHS employees should connect through the remote access service. 
Contact us today for assistance with your information and research needs.
 
3D Printing Medical Supplies: A Web Guide from the NIH Library
 
During the COVID-19 pandemic, “makers” have come together to design, 3D print, and distribute medical supplies. In support of this effort, staff from the NIH Library Technology Hub Team collected and consolidated information about making personal protective equipment, or PPE, in a helpful web guide.
This page will be updated regularly with information about federal guidelines, maker initiatives, scholarly research, and NIH’s involvement. Please note that this is for informational purposes only; the NIH Library does not endorse any plans, models, or organization shared in this guide.
For questions or suggestions about this web guide contact Alicia Lillich, alicia.lillich@nih.gov.

Experience Science in Action with JoVE Science Education Videos

JoVE Science Education videos
 help you and your lab stay up to date on scientific fundamentals with easy-to-follow video demonstrations created by experts at top institutions. The videos can accelerate learning and improve lab productivity; use them to help train new employees, increase retention of techniques and concepts through the video transcripts, reduce time needed to learn new methods, and improve overall productivity and reproducibility.
 
The videos cover a wide range of subjects, including basic and advanced science topics, lab safety, and scientific and research methods. The NIH Library provides access to selected collections, which are available to NIH staff:
Check out the JoVE video collections today and experience science in action.
 
Watch Online Biomedical & Life Sciences Lectures from HSTalks

The NIH Library is pleased to offer the HSTalks Biomedical & Life Sciences Collection. This lecture series features renowned world experts (including NIH researchers and scientists) presenting on a broad range of topics from basic science to therapeutic interventions.

Whether you are interested in the latest on COVID-19 or the use of artificial intelligence in medicine, HSTalks provides access to over 2,900 lectures at introductory, intermediate, and highly advanced levels. Users can browse and search the collection by subject, speaker, and institution. New series and talks are added monthly, and users can sign up for an account to access content offline and earn CME and CPD credits.
 
Example subjects include:
Interested in learning more? Watch this six-minute video. For additional questions or more information, contact Lisa Scanlon, lisa.scanlon@nih.gov.
 
PubMed
 
Do you want to get the most out of PubMed? Use PubMed@NIH, a special edition of PubMed for NIH staff. While PubMed provides access to many published articles for free, many more full-text articles are available to the NIH research communities through PubMed@NIH. Using this tool connects your PubMed searches directly to the NIH Library collection and maximizes your access to full-text articles. It can even save you time when you need to order documents from the Library.
 
How to Access and Use PubMed@NIH
You must have NIH credentials (a PIV card) and be on the NIH campus or connected to the NIH VPN to use PubMed@NIH. Note: you will see “nihlib” at the end of the URL when connected to PubMed@NIH.
  1. Go to the NIH Library website> click on the PubMed@NIH button in the grey bar (below the main search box), or bookmark this link for future reference: http://www.ncbi.nlm.nih.gov/pubmed?otool=nihlib.
  2. Open asingle record in PubMed@NIH in the abstract or full record format.
  3. Click on the blue and green "NIH Library Go" icon in the top right-hand corner of the abstract/record. 
    • If the NIH Library has a subscription to the journal, you will be directed to the full-text article.
    • If the NIH Library does not have a subscription for the article, you will be directed to the NIH Library document delivery form, which will be automatically completed, allowing you to effortlessly submit the order. 
Learn more
For new and advanced PubMed users, join us for a class—click on the links below to learn more and register. Individual and group online tutorials are also available upon request.  
Contact Dera Tompkins, tompkins@nih.gov for more information about using PubMed@NIH, upcoming classes, or tutorials.
HHS and CMS staff: you also have your own PubMed tools. Look for an update from your Librarian
 

Are you looking to increase your search results? Try Embase, a comprehensive tool for searching for information about drugs, devices, and diseases. Embase includes conference abstracts and articles from 2,900 journals that are not in PubMed/MEDLINE and is especially effective for conducting drug and device searches. Embase can also be an important tool to use when doing systematic and other rigorous reviews. 

Embase

How to Access Embase 
You must have NIH credentials (a PIV card) and be on the NIH campus or connected to the NIH VPN to use Embase. Find it on the NIH Library website under the Resources tab at the top of the page, or bookmark this link for future reference: https://www.embase.com/

Learn More 
Join us for a class to learn more about Embase—click on the links below to register. Individual and group tutorials are also available upon request. 
 
September 9, 1:00‒2:00 pm 
This seminar will provide an overview of Embase and demonstrate how it compares to other databases like PubMed. The class will cover designing queries, using form-based queries, developing multiple search strategies, combining searches, and finding conference and literature information. This class was designed for beginners and intermediate users. 
 
September 16, 11:00 am‒12:00 pm 
This advanced training session will focus on using Embase for general literature searching and will cover how to use the database’s embedded tools to design advanced queries for systematic reviews and adverse drug reactions. Participants will also learn how to combine queries to increase search precision, and how to use the PICO (population, intervention, comparison, and outcome) and the PV (Pharmacovigilance) wizards. 
 
Contact Christine Caufield-Noll, christine.caufield-noll@nih.gov, for more information about Embase, upcoming classes, or tutorials. 
 
The NIH Library
301-496-1080