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Other Learning Opportunities for Stay-at-home Scientists

Two Online NIH courses are still open: Principles of Clinical Pharmacology and Principles and Practice of Clinical Research

CIT Technology Training Program - Winter Training Term (1-6) Icon NEW

Science Communication in the Context of a Pandemic: Highlights and Lessons: September 24, 2020

Explore the SACNAS Webinar Library. Newest addition: On-Demand Webinar: Pubic Health in Indigenous Populations

ASCB (American Society for Cell Biology) Webinar

NLM/MLA Leiter Lecture - Dr. John Brownstein on Digital Epidemiology and the COVID-19 Pandemic

Inside the Coronavirus: Special Coverage from Scientific American, fantastic graphics that explain what scientists know now about SARS-CoV-2 now and will be updated as we learn more Icon NEW

NINR Artificial Intelligence Virtual Boot Camp. Videos are now available at https://www.ninr.nih.gov/newsandinformation/events/bootcamp2020

ABRCMS (The Annual Biomedical Research Conference for Minority Students) has created ABRCMS Online

NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”

Supporting People with Addiction During COVID-19: A webinar series from the National Academy of Medicine

NIH Office of Behavioral and Social Sciences Research presentation: "What are we learning from talking to scientists about scientific communication?" May 19, 2020, 2:00 - 3:00 pm EDT

Harvard T.H. Chan School of Public Health Fall Activities. FORUM: The Coronavirus Pandemic: Global Race for a Vaccine, September 15 at noon ET and later on demand and a new session of When Public Health Means Business, September 23 at noon Icon NEW

Summer Content from the Harvard T.H. Chan School of Public Health, including a series on Voices in Leadership during Crises Icon NEW

National Academy of Sciences COVID-19 Update

Virtual Radcliffe Discussion Series: Health Inequity in the Age of COVID-19

1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

NLM Research Symposium: Reporting, Recording, and Remembering the 1918 Influenza Epidemic

PBS Film: “Ken Burns presents The Gene: An Intimate History”, now available for streaming

NIH Begins Study to Quantify Undetected Cases of Coronavirus Infection (read the article)

New Science Webinar from AAAS: Coronavirus: A Survival Guide (now available on demand)

FAES Offerings: FAES Online Workshops for Fall Icon NEW ; An Afternoon with an NIH PI, a recorded lecture series

NIH COVID-19 Lecture Series Icon NEW

Visit the National Academies Press to Download FREE PDFs of Their Reports

Virtual Keystone Symposia: Sessions are available on demand.

NIGMS Training Offerings: NIGMS Virtual Learning Resources AND Webinar Series  Icon NEW

NIAID Bioinformatics and Computational Biosciences Branch Webinars

NIH LIBRARY SERVICES: NIH Library Online Training Classes AND Other Online Services, Training, and Resources, A Web Guide on 3D Printing Medical Supplies; Courses for October and November; JoVE Science Education Videos; Enhance Your Data Science Skills with the SAGE Data Science Video Collection; Introduction to Adobe Illustrator, October 7 Icon NEW


Two Online NIH courses are still open: Principles of Clinical Pharmacology and Principles and Practice of Clinical Research

Principles and Practice of Clinical Research (IPPCR), a free, self-paced, online course is open for registration until July 1, 2021 (the current course year closes on August 1, 2021). Graduate students, post-doctoral scholars, medical, dental, and pharmacy students, scientists, nurses, and other health professionals are encouraged to enroll now.

The IPPCR course is a lecture series from thought-leaders around the world covering:

  • Study Designs, Measurement and Statistics
  • Ethical, Legal, Monitoring, and Regulatory Considerations
  • Preparing and Implementing Clinical Studies
  • Communicating Research Findings and Other Topics

To register, please visit the IPPCR website at https://ocr.od.nih.gov/courses/ippcr.html. If you have any questions, please contact Rebecca Hwang at ippcr2@mail.nih.gov.       

Please feel free to share the course information website link with any internal or external colleagues. We aim to continue to make this course a national and international success!   

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Rebecca Hwang, Office of Clinical Research, ippcr2@mail.nih.gov, 301-451-1468, and/or the Federal Relay (1-800-877-8339).

The Principles of Clinical Pharmacology (PCP) course is a free online lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. Topics covered in the course include pharmacokinetics, drug therapy in special populations, drug discovery and development, and pharmacogenomics.

The course is free, self-paced, and entirely online through the PCP website: https://ocr.od.nih.gov/courses/principles-clinical-pharmacology.html.       

Upon enrollment, course materials are available through August 1, 2021. A certificate of completion is awarded to participants who achieve a passing score on the final exam.

The course will be of interest to graduate students, post-doctoral scholars, medical and pharmacy students, scientists, and health professionals interested in expanding their pharmacology knowledge base.

For additional information on the course, please visit the website above or contact Rebecca Hwang at odpcp@mail.nih.gov. Please feel free to share the course information with any internal or external colleagues that you feel may benefit from the course.

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Rebecca Hwang, NIH Office of Clinical Research, odpcp@mail.nih.gov, 301-451-1468, and/or the Federal Relay (1-800-877-8339).


CIT Technology Training Program - Winter Training Term (1-6-21)

 

Winter is the time for comfort, for warmth beside a fire, and for our Winter training term to begin.

As the outbreak of COVID-19 continues, we will present our training sessions via WebEx; at this time, space will be limited for better facilitation.

Would you like to learn more about virtual meetings?  Are you looking to make your documents Section 508 compliant?  Are you using Microsoft Office 2016 applications?  We can be of assistance.  There is no charge for most of the courses and seminars (any charges would be listed with the course description), and registration is open to NIH staff as well as all users of CIT computing facilities.  Please use the links below to find more details about the courses and to register online.

Would you like to learn more about Microsoft Office 2016 applications:

Do you work with a Mac:

Are you interested in unified communications and web technologies:

We also have Accessibility sessions available:

Additional sessions include:

Information to join a webinar session will be sent to those who are enrolled via e-mail from the instructor. Any documents required for the training will be included. If you have not received this information by the day of the session, please e-mail us at cittraining@mail.nih.gov.

If you have expertise you would consider sharing with those in the NIH community, please contact us. We have extensive instructor support services (e.g. obtaining publications for instructors, polishing course descriptions, e-mailing course materials, setting up projection systems, etc.) to make efficient use of your time and make your presentation effective.

We also coordinate outside training personnel, classroom rental, resources, registration, and other related activities in support of training events for a nominal fee to cover complete cost recovery.

If you have any questions or need assistance with registering for sessions, please contact us by email at CITTraining@mail.nih.gov.


Science Communication in the Context of a Pandemic: Highlights and Lessons

September 24, 2020

During the rapidly evolving COVID-19 pandemic, timely, accurate, and concise communication is vital to ensure public understanding of the scientific basis for the advice they receive. The panelists will identify difficulties in science communication scenarios where there is uncertainty and urgency, together with optimal strategies for scientists and science communication professionals to cope with these challenges.

Watch the Video.


Explore the SACNAS webinar library.

On-Demand Webinar: Pubic Health in Indigenous Populations Icon NEW


In this new webinar, Donald Warne, MD, MPH, (Oglala Lakota) shares what Native people and communities need to be aware of and consider when dealing with COVID-19, by providing an in-depth look into Indigenous health, history, and policy. Dr. Warne is Associate Dean of Diversity, Equity, and Inclusion; Director, MPH Program & INMED Program; and Professor, Family & Community Medicine at UND School of Medicine and Health Sciences.

Watch now.


ASCB (American Society for Cell Biology) Webinar

 

Non-tenure-track Career Paths in Academia: October 13 (video available)


NLM/MLA Leiter Lecture - Dr. John Brownstein on Digital Epidemiology and the COVID-19 Pandemic: August 11, 2020

John S. Brownstein is professor of biomedical informatics at Harvard Medical School and is the chief innovation officer of Boston Children’s Hospital. He also directs the Computational Epidemiology Lab and the Innovation and Digital Health Accelerator, both at Boston Children’s Hospital. Brownstein is also Uber’s health care advisor and cofounder of the digital health companies Epidemico and Circulation. He will be speaking on the surveillance, control, and prevention of disease, the development and application of data mining, and citizen science to public health in relation to his work with the COVID-19 pandemic.


 

NINR Artificial Intelligence Virtual Boot Camp

In August, the National Institute of Nursing Research (NINR) will hold a four-day virtual boot camp to explore the impact that Artificial Intelligence (AI) has in the evolving healthcare environment, and overall efforts to improve the quality of care for patients and families. The goal is to enable attendees to understand basic principles of AI and how clinicians can form strategic alliances with data scientists to carry out research on data-driven intelligent hardware and software approaches to health-related issues. The event will be broadcast live via VideoCast and archived for later viewing.

Objectives:

  • Describe the field of Artificial Intelligence (AI) and explore the role of AI to promote health, and to prevent illness.
  • Discuss strategies to build partnerships and collaborations among clinicians and scientists.
  • Explore AI data collection, including ethical, legal, and social implications.
  • Analyze clinical and translational AI applications that can reach more diverse patient populations and improve the safety, efficacy, and quality of healthcare.

Boot Camp Agenda:

  • [8/3/2020] Session I: Innovations and Improvements in Health Outcomes
  • [8/4/2020] Session II: Clinical Applications
  • [8/5/2020] Session III: Ethical, Legal, And Social Implications
  • [8/6/2020] Session IV: Collaborative Science

 

ABRCMS (The Annual Biomedical Research Conference for Minority Students) has created ABRCMS Online Icon NEW

ABRCMS Online is an extension of the conference that allows the biomedical sciences community to continue learning, with resources for students, trainees, faculty, and community.


NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”

Sequence-Structure-Function Modeling for the 3D Genome

 

The National Library of Medicine’s Ada Lovelace Computational Health Lecture Series presents, "Sequence-Structure-Function Modeling for the 3D Genome", Thursday, January 28, 2021 | 2:00 to 3:00 pm | NIH Videocast

The talk will be delivered by Katherine S. Pollard, PhD, Director, Gladstone Institute of Data Science and Biotechnology, Professor and Investigator, Chan Zuckerberg Biohub at the University of California San Francisco.

Ada Bryon Lovelace developed the idea of Poetical Science, which emphasizes the importance of intuition and image in mathematics and science. Poetical Science comprises three key features: observation, interpretation, and integration. A brilliant mathematician, Lovelace is broadly recognized as the first computer programmer. A key example of Poetical Science is her observation of a punch card-driven loom in a weaving factory that subsequently led to the mathematics that operationalized Charles Babbage's computing machine. In this talk, Dr. Pollard will discuss how the human genome sequence folds in three dimensions (3D) into a rich variety of locus-specific contact patterns.

Despite growing appreciation for the importance of 3D genome folding in various aspects of cell biology, there is a lack of models for relating mutations in genome sequences to changes in genome structure and function. Towards that goal, Dr. Pollard and her colleagues discovered that the organization of gene regulatory domains within this structure and the specific sequences that sit at boundaries between domains are under strong negative selection in the human population and over primate evolution. Motivated by this signature of functional importance, Dr. Pollard’s team developed a deep convolutional neural network, called Akita, that accurately predicts genome folding from DNA sequence alone. Representations learned by Akita underscore the importance of the structural protein CTCF but also reveal a complex grammar beyond CTCF binding sites that underlies genome folding. Akita has enabled rapid in silico predictions for effects of sequence mutagenesis on the 3D genome, including differences in genome folding across species and in disease cohorts, which are being validated with CRISPR-edited genomes. This prediction-first strategy exemplifies Dr. Pollard’s vision for a more proactive, rather than reactive, role for data science in biomedical research.

Dr. Pollard earned her BA at Pomona College and her master’s degree and PhD in biostatistics from UC Berkeley. At Berkeley, she developed computationally intensive statistical methods for the analysis of microarray data with applications in cancer biology. She implemented these approaches in Bioconductor, an open-source software program used with high-throughput genomic data. As a comparative genomics postdoctoral fellow at UC Santa Cruz, Pollard participated in the Chimpanzee Genome Project and used this sequence to identify the fastest-evolving regions in the human genome, known as Human Accelerated Regions.

Before joining Gladstone, Dr. Pollard was an assistant professor in the Genome Center and Department of Statistics at UC Davis. She was awarded the Thomas J. Watson Fellowship in 1995 and the Sloan Research Fellowship in 2008. Dr. Pollard is a fellow of the California Academy of Sciences and a Chan Zuckerberg Biohub Investigator. In 2018, she became the founding director of the Gladstone Institute of Biotechnology and Data Science. Dr. Pollard is a member of the American Society of Human Genetics, the American Statistical Association, and the International Society for Computational Biology.

This lecture is sponsored by the National Library of Medicine (NLM) Acting Scientific Director and David Landsman, PhD, Chief, Computational Biology Branch at NLM's National Center for Biotechnology Information.

This lecture will be live-streamed globally, and subsequently archived and available for viewing, at: https://videocast.nih.gov/watch=41362.

Individuals with disabilities who need reasonable accommodation to participate in this event should contact Valerie Bartlett, bartletv@mail.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.

Submit questions during the meeting to: NLMEPInfo@mail.nih.gov.

 

Implications of Poetical Science for Advancing Health Equity through Information Visualization


Suzanne Bakken, PhD, RN, FAAN, FACMI, FIAHSI, Alumni Professor of Nursing and Professor of Biomedical Informatics at Columbia University presented the National Library of Medicine’s Ada Lovelace Computational Health Lecture on December 7, 2020. The title of her talk was “Implications of Poetical Science for Advancing Health Equity through Information Visualization”

In this talk, Dr. Bakken will use the lens of Poetical Science to describe a program of research focused on advancing health equity of urban Latinos through use of information visualization. This will include the integration of perspectives from the fields of health equity, nursing science, health literacy, health communication, and information visualization.

Suzanne Bakken, PhD, RN, FAAN, FACMI, FIAHSI, is the Alumni Professor of Nursing and Professor of Biomedical Informatics at Columbia University. Following her doctorate in Nursing at the University of California, San Francisco, she completed a post-doctoral fellowship in Medical Informatics at Stanford University. Her program of research has focused on the intersection of informatics and health equity for more than 30 years and has been funded by AHRQ, NCI, NIMH, NINR, and NLM. Dr. Bakken’s program of research has resulted in more than 300 peer-reviewed papers. At Columbia Nursing, she leads the NINR-funded Precision in Symptom Self-Management (PriSSM) Center and Reducing Health Disparities Through Informatics (RHeaDI) Pre- and Post-doctoral Training Program.

She is a Fellow of the American Academy of Nursing, American College of Medical Informatics, International Academy of Health Sciences Informatics, and a member of the National Academy of Medicine. Dr. Bakken has received multiple awards for her research including the Pathfinder Award from the Friends of the National Institute of Nursing Research, the Nursing Informatics Award from the Friends of the National Library of Medicine, the Sigma Theta Tau International Nurse Researchers Hall of Fame, and the Virginia K. Saba Award from the American Medical Informatics Association. Most recently, she was the first nurse recipient of the Francois Gremy Award from the International Medical Informatics Association. Dr. Bakken currently serves as Editor-in-Chief of the Journal of the American Medical Informatics Association and a member of the National Library of Medicine’s Board of Regents.

This lecture is sponsored by Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine and David Landsman, PhD, Chief, Computational Biology Branch at the NLM’s National Center for Biotechnology Information.

This lecture will be live-streamed globally, and subsequently archived, by NIH video casting: https://videocast.nih.gov/watch=40070.

Dynamic Genome Rearrangements in the Ciliate Oxytricha


The talk was delivered on October 13, 2020, by Dr. Laura Landweber, PhD, Professor of Biochemistry & Molecular Biophysics and of Biological Sciences, Columbia University.

Topic:  The ciliate Oxytricha trifallax possesses a complex pair of genomes, and massive DNA rearrangements produce a highly fragmented but functional somatic macronucleus from a complex germline micronucleus. This process eliminates nearly all noncoding DNA, including transposons, and rearranges over 225,000 short DNA segments to produce a second genome containing thousands of gene-sized "nanochromosomes”. The mature, somatic genome contains over 17,000 nanochromosomes. Noncoding RNAs regulate the entire process of genome rearrangement. Millions of parental 27nt small RNAs provide the critical information to mark and protect the retained DNA segments of the genome. These and other processes illustrate the multifaceted ability of noncoding RNAs to transmit heritable information to the next generation.

Dr. Laura Landweber is a Professor in the Departments of Biochemistry & Molecular Biophysics, Biological Sciences, and Systems Biology, in the Colleges of Physicians & Surgeons and Arts & Sciences. Prior to moving her lab to Columbia University Medical Center she was faculty at Princeton University from 1994-2016, and a Junior Fellow of the Society of Fellows at Harvard University, where she received her PhD in 1993. She has authored over 150 publications in molecular and evolutionary biology and edited 3 books, in areas ranging from genetics and evolution to biological computation. She is President (2017) of the Society for Molecular Biology and Evolution (SMBE) and has served on several panels, working groups, and advisory committees for the NSF, NIH, and NASA, including co-chairing the NHGRI Comparative Genome Evolution Working Group from 2003-2007. Recent awards include a Guggenheim fellowship (2012) and a Blavatnik award for young scientists (2008), and she was elected a Fellow of AAAS for probing the diversity of genetic systems in microbial eukaryotes, including scrambled genes, RNA editing, variant genetic codes, and comparative genomics. Her work investigates the origin of novel genetic systems and complex genome architectures, using the ciliate Oxytricha as a model. Recent discoveries include the ability of small and long non-coding RNA molecules to program genome organization across generations, bypassing the information encoded in DNA.

This lecture is sponsored by David Landsman, PhD, Director of the Computational Biology Branch, NCBI, and Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine

This lecture is archived at https://videocast.nih.gov/watch=37909.

Computational Tools for the Classification, Prediction, and Characterization of a Pandemic

The first lecture in NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”, was presented Wednesday, June 24, 2020, by by Dr. John H. Holmes, PhD, FACE, FACMI, FIAHSI, Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine.

Traditional methods of epidemic modeling continue to be used fruitfully for characterizing outbreaks and predicting the spread of disease in populations. However, these methods, typically rely on what are known as “compartment models”, requiring assumptions that are not necessarily sensitive to the ever-changing environmental, behavioral, temporospatial, and social phenomena that influence disease spread. Compartment models can be enriched by the judicious use of robust methods drawn from the field of artificial intelligence that allow us to model more accurately and more quickly the population and disease dynamics that are central to developing policies for prevention, detection, and treatment. We will explore these approaches, including some that are currently in use as well as a proposal for novel, next-generation machine learning tools for epidemiologic investigation.

This lecture was sponsored by Valerie Florance, PhD, Associate Director of the National Library of Medicine, Division of Extramural Programs and Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine

A recording of the lecture is available: https://videocast.nih.gov/watch=37909.


 

Supporting People with Addiction During COVID-19: A webinar series from the National Academy of Medicine

Individuals experiencing addiction are a vulnerable population that have been significantly impacted by the COVID-19 pandemic. Physical distancing protocols have separated patients from their clinicians, made medications to treat addiction much more challenging to obtain, and shuttered many long-term recovery groups. 

A new webinar series from the NAM and the American Society of Addiction Medicine will provide insight and targeted guidance on how to ensure that these individuals are cared for and protected during this ongoing public health crisis.

Webinar 1: Helping People with Addiction Stay Connected during COVID-19. Available as a video recording.


NIH Office of Behavioral and Social Sciences Research presentation: "What are we learning from talking to scientists about scientific communication?" May 19, 2020, 2:00 - 3:00 pm EDT

Register: https://obssr.od.nih.gov/what-we-are-learning-from-talking-to-scientists-about-science-communication .

Presentation Overview:

In recent years, Dr. John Besley has shifted his research from the study of public opinion about science to trying to understand scientists' opinion about the public.

As part of this work, he and his collaborators have advanced a framework for strategic science communication that emphasizes setting clear behavioral goals and then working backwards to identify communication objectives that have the potential of affecting desired behaviors, as well as tactics to help achieve the communication objectives. This perspective puts identifying and prioritizing specific communication objectives at the core of being an effective communicator.

Dr. Besley will share his thinking along with selected data from his surveys and interviews of scientists.

John Besley, Ph.D., is Ellis N. Brandt Professor of Public Relations at Michigan State University.

The recording of this webinar will be available with closed captioning on OBSSR’s website approximately two weeks following the webinar: https://obssr.od.nih.gov/what-we-are-learning-from-talking-to-scientists-about-science-communicatio.


 

Harvard T.H. Chan School of Public Health Fall Activities:

 

 

FORUM: The Coronavirus Pandemic (Presented jointly with NPR)

 

Mental Health in the Time of COVID-19, January 27, 2021, 1:00-2:00 pm ET. Register to watch.

Earlier sessions are available on demand.

The COVID-19 Vaccine Rollout,January 22, 2021
The Disrupted School Year and Public Health, January 12, 2021
COVID-19: The Year Ahead, December 15
Airborne Transmission, Ventilation and School and Workplace Reopenings December 11
Mental Health Fatigue, the Holidays, and Resiliency, November 17
The Coronavirus Pandemic: Surging Cases, Rapid Diagnostics, and New Vacines, December 1, 2020
Race for the COVID-19 Vaccine: Latest Updates, November 20
THE 2020 ELECTION: Impacts on Health Policy and More, November 13
Innovating on Campus: Supporting Mental Health of Students of Color during COVID-19 and Beyond October 27
Latest Updates, Approaching the Holidays, October 13
More Surges, Growing Concerns, October 8
Will People Accept a COVID-19 Vaccine?
 October 2
Serious Impacts on Minority Communities in U.S. Cities, September 30

Reopening Schools and Workplaces, September 22
Global Race for a Vaccine, September 15

Human Rights = Public Health: A Discussion with Michelle Bachelet, UN High Commissioner for Human Rights

October 6, 2020.

The event, which was co-sponsored by the David Rockefeller Center for Latin American Studies at Harvard University, is available on-demand.

FORUM: Innovating in the Workplace (Presented in partnership with The Steve Fund and jointly with WGBH News)


Supporting the Mental Health of Young People of Color during COVID-19 and Beyond, October 27, 2020

When Public Healh Means Business, Part 5


Wednesday, September 23, 2020, 1:00-2:00 pm (EDT)

The current COVID-19 pandemic has revealed a plain truth: We can no longer afford to operate in silos. Instead, this once-in-a-lifetime public health crisis demands a remarkable level of cooperation across sectors and disciplines. Now more than ever, public health and business need to forge ahead together to clear the runway for our economy and society to thrive.

What will it take to move forward globally? How do we battle the war against science? What will it take to succeed? How can we prepare now for the next pandemic?

Watch live and find links to the 5 earlier sessions in the series.


Summer Content from the Harvard T.H. Chan School of Public Health, including a series on Voices in Leadership during Crises

 

Selected Forum and Voices in Leadership (VIL) During Crises Videos with Searchable Transcripts

The Coronavirus Pandemic: Equity, Impacts and Global Fragile Communities, (August 11, 2020)
VIL: Deval L. Patrick, 71st Governor of Massachusetts (July 23, 2020)
The Coronavirus Pandemic: Unequal Risks for Communities of Color, (July 21, 2020)
The Coronavirus Pandemic: Advances in Testing, Fighting the Surge, (July 14, 2020)
The Coronavirus Pandemic: Surging Cases, A Growing Crisis, (July 7, 2020)
Food Insecurity, Inequality and COVID-19, (June 30, 2020)
VIL: Martin J. Walsh, 54th Mayor of the City of Boston (June 24, 2020)
The Coronavirus Pandemic: What’s Next, (June 23, 2020)
Racism and COVID-19: Inequities and Policing, (June 18, 2020)
VIL: Michelle A. Williams, Dean of the Faculty, Harvard T.H. Chan School of Public Health, and Jeffrey Sánchez, Former Massachusetts State Representative (June 11, 2020)
VIL: Karl Lauterbach, Professor of Health Economics and Clinical Epidemiology, University of Cologne, Member of the Deutsche Bundestag (MdB (June 4, 2020)
The Coronavirus Pandemic: Stopping the Spread of Misinformation, (May 26, 2020)
The Coronavirus Pandemic: Responding Now and Averting Future Crises, (May 19, 2020)
The Coronavirus Pandemic: Antibody Testing and Reopening Society, (May 15, 2020)
The Coronavirus Pandemic: Safely Reopening Workplaces, (May 12, 2020)
The Coronavirus Pandemic: Potential Vaccines and Treatments, (May 7, 2020)
The Coronavirus Pandemic: Mental Health, Stress and Resiliency, (May 5, 2020)

Additional programming hosted by The Forum

When Public Health Means Business

A multipart series that virtually convenes luminaries from the realms of finance, industry, and health to map a new path forward through COVID-19 and beyond. Presented jointly by the Harvard T.H. Chan School of Public Health and the New England Journal of Medicine and hosted by The Forum. 

#FirstRespondersFirst: The Path Forward

Event presented jointly by the Harvard T.H. Chan School of Public Health, Thrive Global, and the CAA Foundation and hosted by The Forum at the Harvard T.H. Chan School of Public Health (July 29, 2020). 

Podcasts of Forum events with The World from PRX & WGBH

Coronavirus Conversations: How the coronavirus affects already fragile communities
Coronavirus Conversations: How the coronavirus crisis has exposed entrenched health inequities
Coronavirus Conversations: Can advances in testing counter surging COVID-19 cases?
Coronavirus Conversations: Are countries prepared for a coronavirus surge?
Coronavirus Conversations: How the pandemic is exacerbating food insecurity and global inequities
Coronavirus Conversations: What's next in the fight against the coronavirus?
Coronavirus Conversations: How systemic racism intersects with the pandemic
Coronavirus Conversations: Stopping the spread of misinformation amid the coronavirus crisis
Coronavirus Conversations: Lessons from the coronavirus pandemic to avert a future crisis
Coronavirus Conversations: How do we reopen workplaces safely amid the coronavirus crisis?

Short Videos: Coronavirus Pandemic: Harvard Chan Experts Answer Your Questions

Mary Bassett: Why are low income, people of color at higher risk for COVID-19?Caroline Buckee: Is the current state of testing an accurate indicator of case numbers right now?
Vish Viswanath: Why is there so much misinformation circulating about COVID-19?
David Harris: Can we tackle disparities that put communities of color at higher risk for COVID-19?
Joseph Allen: Will companies screen and test employees for COVID-19?


National Academy of Sciences COVID-19 Update

Saturday, April 25, 2020
2:00 p.m. EDT

  •  Jeremy Farrar, Director, Wellcome Trust (confirmed)
  •  Anthony S. Fauci, Director, National Institute of Allergy and Infectious Diseases (accepted, schedule permitting)
  •  George F. Gao, Director-General, Chinese Center for Disease Control & Prevention (confirmed)
  •  Susan R. Weiss, Professor of Microbiology, Perelman School of Medicine, University of Pennsylvania (confirmed)
  •  Richard J. Hatchett, CEO, Coalition for Epidemic Preparedness Innovations (confirmed)
  •  Sanjay Gupta, Chief Medical Correspondent, CNN (confirmed)

http://www.nasonline.org/about-nas/events/annual-meeting/nas157/covid19-update.html

 


Virtual Radcliffe Discussion Series: Health Inequity in the Age of COVID-19

 
The Radcliffe Institute is launching a new Virtual Radcliffe programming platform to offer lectures and conferences that connect leading scholars and practitioners with the public and advance discourse on pressing issues. Beginning on Thursday, April 23, Radcliffe will host a series of discussions examining the grave health inequities revealed and exacerbated by COVID-19, which is disproportionately impacting vulnerable and marginalized communities. Recordings are now available.

Health, Inequity, and COVID-10

April 28, 2020

International experience in recent months has powerfully illustrated that the COVID-19 virus has particularly harmful and disproportionate effects on already vulnerable populations. Mary Bassett and Khalil Gibran Muhammad will discuss inequity and public health in the time of COVID-19, exploring how the virus encounters existing inequalities, replicates these inequalities, and, in many cases, amplifies them.

Ensuring Health Equity for Persons with Disabilities: The Context and Ethics of Health Rationing Protocols during COVID-19

Thursday, April 23, 2020

As COVID-19 threatens to push hospital resources beyond capacity, states, hospitals, and advocacy organizations have formulated protocols to address potential discrimination against persons with disabilities. Highly influential statements by the Arc and the University of Pittsburgh are setting new standards for the ethical treatment of persons with disabilities. This Radcliffe webinar places these triaging policies within the context of the history of disability civil rights, culture, and bioethics and considers what is necessary to achieve equitable health outcomes for persons with disabilities during this time of crisis.


1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

https://www.youtube.com/watch?v=UDY5COg2P2c&feature=emb_rel_end

Historical documentary about 1918 Swine Flu or Spanish Flu and the role of World War I in spreading the disease among troops making it into a worldwide plague of devastating proportions. The video covers where it began, how and where it spread, the symptoms, how it affected America and whether it could happen again.


NLM Research Symposium: Reporting, Recording, and Remembering the 1918 Influenza Epidemic

The symposium will be held virtually on Wednesday, April 29, 2020, 2:00-4:00pm ET, via streamlined Webex to reduce bandwidth usage, while being livestreamed and subsequently archived by NIH Videocasting as part of its archive of past NLM history of medicine events.

Watch and hear the program via this URL: https://videocast.nih.gov/watch=36347

Join us to learn the research outcomes of Virginia Tech students studying the history of data in social context through individual and collaborative primary-source research here at the NLM and elsewhere, and as part of their course Topics in the History of Data in Social Context, being taught by Dr. E. Thomas Ewing.

During the symposium, the students will present their research on various aspects of the 1918 pandemic, including newspaper reporting at the peak of the epidemic (late September to early November 1918), contemporary social distancing policies and procedures, and how contemporaries determined that the epidemic was ending, and how they remembered the remarkable experience of this intense, but relatively brief, crisis in community health.

Discussants will include Dr. Nancy Bristow of the University of Puget Sound and author of American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford University Press, 2012), among others to be announced.

All are welcome to tune-in to this research symposium which advances the NLM 2017-2027 strategic plan emphasizing data-driven discovery, enhanced stakeholder engagement, and the role of libraries and archives in providing trusted information.

Reporting, Recording, and Remembering the 1918 Influenza Epidemic is sponsored by the NLM History of Medicine Division in cooperation with the National Endowment (NEH) for the Humanities Office of Digital Humanities—as part of the ongoing NLM/NEH partnership to collaborate on research, education, and career initiatives.

Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact Dr. Stephen Greenberg at greenbes@mail.nlm.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.


PBS Film: “Ken Burns presents The Gene: An Intimate History” -- aired April 7 & 14. You can now stream it from https://www.pbs.org/kenburns/the-gene/.

 
A new PBS film, “Ken Burns presents The Gene: An Intimate History,” based on the book by Dr. Siddhartha Mukherjee, will air in two parts: tomorrow, April 7 at 8 pm ET and next Tuesday, April 14 at 8 pm ET.  Dr. Mukherjee shared his insights on the book with NIH staff in April 2017 as part of the NIH Big Read series (https://videocast.nih.gov/summary.asp?live=21833&bhcp=1).

For more than two years, the National Human Genome Research Institute (NHGRI) has been proud to support the education and outreach associated with this film, and the NIH Office of the Director, the National Institute of General Medical Sciences, and others across NIH have also contributed substantially.

The film describes the history of genetics, from Mendel to modern day. It brings to life the story of today’s revolution in medical science through present-day tales of patients and doctors at the forefront of the search for genetic treatments, interwoven with a compelling history of the discoveries that made this possible and the ethical challenges raised by the ability to edit DNA with precision.

The filmmakers interviewed many NIH staff and NIH-funded researchers in making the documentary, and you will see multiple NIH employees featured in the final cut. For example, Dr. Francis Collins and I were given the opportunity to recount the excitement of the Human Genome Project and its incredible legacy, including the birth of NHGRI and the increased investments in genetics and genomics by all parts of NIH.


New Science Webinar from AAAS: Coronavirus: A Survival Guide

Thursday, 16 April 2020, 11 a.m. Eastern, 8 a.m. Pacific, 4 p.m. UK (BST), 5 p.m. Central Europe (CEST)
Now available on demand.

  • What the coronavirus is and how it makes you sick
  • What you can do to protect yourself, and keep your friends and family safe
  • How you can build resilience to deal with this new way of life
  • What the end of this pandemic might look like 
  • Where you can get the latest information about the virus that is accurate and trustworthy.

FAES Offerings

 

New January Intersession With Special Coding Course for Beginners

FAES is pleased to offer BIOF101 Introductory Coding, a new online course that will teach novice students the needed programming skills for success in academic, scientific and industrial settings. Students will first learn the basic components of programming, such as variables, conditionals, loops, object-oriented programming and simple data structures.  Students will also be taught how to properly prepare a computer for efficient and effective programming. Students will then apply basic programming principles by using the Python programming language to complete assignments that reflect real-word tasks. Finally, students will put together a plan for further programming education. No prior knowledge of programming is necessary to be successful in this class.

BIOF101 will run from January 11 - January 29th.  For students affiliated with NIH, tuition is $75 and for non-NIH students, tuition is $100. To register, go to https://faes.org/courses.

If you have any questions, please email registrar@faes.org or call 301-496-7976.

Individuals with disabilities who need reasonable accommodation to take FAES classes should contact registrar@faes.org. Requests should be made at least five days in advance.

 

Upcoming FAES Online Workshops: ... Register Now!

       2020      

       December

       December 15 - 17, 2020                   Intro to Data Science with Python

       2021      

       January

       January 4 - 8, 2021                            Microbiome Bioinformatics with QIIME2 Registration Ends December 14, 2020
       January 11, 25 & February 1, 2021        Project Management Essentials      
       January 12 - 14, 2021                        Introduction to Text Mining using Python
       January 19 - February 4, 2021             Python for Beginners  Evening
       January 25 - 29, 2021                        Genome Editing with CRISPR
       January 27 - 29, 2021                        Introduction to Statistical Analysis in R

       February

       February 2 - 4, 2021                          Molecular Modeling and Molecular Dynamics: Hands-on Training
       February 8 - 12, 2021                        Visualization with R
       February 9, 16, 23, 2021                   Introductory R Boot Camp  Evening
       February 16 - 19, 2021                      Introduction to Deep Learning
       February 17 - 20, 2021                      For True BeginRs | Hands-on R Training Wednesday - Saturday
       February 23 - 26, 2021                      Cellular Immunology

       March      

       March 2 - 4, 2021                               MATLAB Fundamentals Registration Ends February 1, 2021​
       March 9, 16, 23, 2021                        Intermediate R Boot Camp Evening

       April

       April 6, 13, 20, 2021                          Designing Effective Data Visualizations in R Evening
       April 14 - 15, 2021                             Image Processing and Analysis

Pricing varies by workshop. Pricing and registration information is at: https://faes.org/workshops-conferences.

Questions: registrar@faes.org or call 301-496-7977

Individuals with disabilities who need reasonable accommodation to take FAES classes should contact registrar@faes.org. Requests should be made at least five days in advance.

 

An afternoon with an NIH PI, a new lecture series hosted by FAES

 
We are excited to announce a new virtual lecture series called “An afternoon with an NIH PI” during May 2020 in which prominent scientists from the NIH will share their latest research and insights into their career path. Attendees will be able to submit questions during and after the seminar via chat, and those will be discussed at the end of the seminar. Recordings of all the lectures are now available at https://faes.org/content/an-afternoon-with-an-NIH-PI.

  1. A Drug's Purpose: From ED to Viral Hepatitis to COVID-19
    Jake Liang​, MD | NIH Distinguished Investigator, Chief, Liver Diseases Branch, NIDDK

  2. Role of the Microbiota in Immunity and Repair
    Yasmine Belkaid, PhD​ | Chief, Metaorganism Immunity Section, NIAID

  3. Big-Small, Tall-Short, Big Ears-Little Ears: What is the Genetics of it All?
    Elaine Ostrander, PhD | NIH Distinguished Investigator, Cancer Genetics and Comparative Genomics Branch, NHGRI
     
  4. Self-Renewal, Differentiation and Transformation in Hematopoiesis and in Science
    Cynthia Dunbar, MD | Chief, Translational Stem Cell Biology Branch, NHLBI
     
  5. From Axon Damage to Disease: Common Pathways in Neurodegeneration
    Claire Le Pichon, PhD | Investigator, Unit on the Development of Neurodegeneration, NICHD

  6. scRNAseq Developmental Trajectories to Investigate Differentiation
    Jeff Farrell, PhD | Earl Stadtman Investigator, Unit on Cell Specification and Differentiation, NICHD

  7. Biological Imaging at High Spatiotemporal Resolution (and How I Got into This)
    Hari Shroff, PhD | Senior Investigator, Laboratory of High Resolution Optical Imaging, NIBIB

NIH COVID-19 Lecture Series

Fall 2020 Lectures

The NIH COVID-19 Scientific Interest Group (SIG) Lecture Series will resume on October 1, 2020. We are writing to let you know that the lecture series has a new day and time: the first and third Thursday of each month at 12:00 pm (ET). The lectures will be available live and archived at videocast.nih.gov.

October 1: Paul Bieniasz (Rockefeller University) "Neutralizing Antibodies to SARS-CoV-2."
October 15: Kizzmekia Corbett (NIH) "SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness."
November 5: E. John Wherry (Perelman School of Medicine, UPenn) "Immune Profiling to Understand COVID-19 Pathogenesis."
November 19: Christine Grady (NIH) "Ethical Quandaries in the COVID-19 Pandemic."
December 3: Helen Su (NIH) "Genetic Studies Illuminating Pathways Important for Controlling COVID Disease."
December 17: James J. Collins (Wyss Institute at Harvard) "Harnessing Synthetic Biology and Deep Learning to Address the COVID-19 Pandemic."

For more information about the COVID-19 Scientific Interest Group, refer to https://oir.nih.gov/sigs/covid-19-scientific-interest-group.

Sign-language interpreters can be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Jacqueline Roberts, robertsjm@od.nih.gov, 301-594-6747, or the Federal Relay, 800-877-8339.

— The COVID-19 SIG Leadership


Spring and Summer 2020 Lectures

 

SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects," by Alessandro Sette, Ph.D., professor and member of the La Jolla Institute for Immunology, La Jolla, CA, July 29. This lecture is now archived.

For his lecture, Dr. Sette will review data examining the nature and specificity of T cell responses to SARS-CoV-2 from convalescent and acute donors, and in non-exposed subjects.  Over the past three decades, the Sette lab has defined in chemical terms the specific structures that the immune system recognizes, and it has capitalized on this knowledge to measure and understand immune responses.  This approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.  Turning to SARS-CoV-2, Dr. Sette and his colleagues applied this approach to provide the one of the first assessments of whether the immune system can mount a substantial and lasting response, finding evidence of T cell reactivity against and pre-existing immunity to SARS-CoV-2.  Dr. Sette will highlight these and other findings in his talk.

COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far," by Stefania Pittaluga, M.D., and David Kleiner, M.D., Ph.D., senior research physicians in the NCI-CCR Laboratory of Pathology, July 22. This lecture is now archived.

Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published.  Although most patients experience mild symptoms, some have serious complications—including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia—that contribute to the high mortality rate.  Autopsies can offer a better understanding of the underlying pathophysiology.  Unfortunately few autopsies were performed early in the pandemic because of the potential risks.  Untreated patients who died of SARS-CoV-2 were rarely autopsied.  Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs.  We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH.  We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.

Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing," by Dan Anderson, Ph.D., professor of chemical engineering and of health sciences and technology at the MIT Koch Institute for Integrative Cancer Research, July 15. This lecture is now archived.

High–throughput, combinatorial approaches have revolutionized small-molecule drug discovery.  Dan Anderson will describe his work on the combinatorial development of nanoparticulate, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized, formulated, and screened for their ability to deliver macromolecular payloads inside of cells.  These nanoformulations facilitate in vivo delivery, enabling gene suppression with small-interfering RNA, gene expression with messenger RNA, or permanent genetic editing using the CRISPR/Cas9 system.  Formulations have been developed with in vivo efficacy and show potential therapeutic applications for a range of different diseases.  This lecture will focus on the application of these formulations toward controlling the immune system and in particular as vaccines for infectious disease.

 

Lessons Learned: Management and Treatment during COVID-19 Pandemic

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Lessons Learned: Management and Treatment during COVID-19 Pandemic," by Judith A. Aberg, M.D., chief of Infectious Diseases, Icahn School of Medicine at Mount Sinai, and a member of the panel developing NIH COVID-19 Treatment Guidelines, July 8. This lecture is now archived.

Dr. Aberg will briefly discuss what is new in the pathogenesis of SARS-CoV-2 and how this affected the decision-making processes on the management and treatment of SARS-CoV-2 infection during the COVID-19 pandemic in New York City. Even in the absence of data and insufficient knowledge of what may or may not work, the Mount Sinai Health System created treatment guidelines that were updated frequently based on physicians' observations and information gathered from multiple disciplines across the system. Dr. Aberg will present a few lessons learned that affected the quality-of-care of patients. The majority of her talk will focus on how clinical observations at the Mount Sinai Health System and how social media and knowledge imparted from colleagues across the globe influenced clinical decision making. Dr. Aberg will close the talk with a summary of how she and her colleagues are better prepared for the future, the knowledge they have gained, and the potential therapeutic options currently under investigation.

High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria," by Dorothee von Laer, M.D., Medical University of Innsbruck, July 1. This lecture is now archived.

In early March 2020, a SARS-CoV-2 outbreak at a ski resort in Ischgl, Austria, initiated the spread of SARS-CoV-2 throughout Austria and Northern Europe. Thousands of infections can be traced back to Ischgl. In a recent study by Medical University of Innsbruck investigators, 42.4 percent of those living in Ischgl were shown to be carrying the new coronavirus antibodies, indicating they had been infected in the COVID-19 pandemic. Between April 21 and 27, a cross-sectional epidemiologic study targeting the full population of Ischgl (n= app. 1,867), of which 79 percent could be included (n=1473), was performed. For each individual, the study involved a SARS-CoV-2 PCR test for the virus, antibody testing, and a questionnaire. In addition, the SARS-CoV-2 PCR+ cases reported to the authorities were included. The seroprevalence was 42 percent and individuals under 18 showed a significantly lower seroprevalence (27 percent) than adults (45 percent). However, only 105 study participants remembered if they had a previous positive PCR result. The clinical course was generally mild and only two individuals in Ischgl had died from infection corresponding to an infection fatality rate (IFR) of 0.26 percent. In the first week of April, a public screening in Ischgl had found 19 percent of the population to be PCR+. However, only 8 (0.5 percent) individuals were newly diagnosed to be infected with SARS-CoV-2 during the study conducted 2-3 weeks later.  Ischgl was hit early and hard by SARS-CoV-2, which led to a high local seroprevalence of 42 percent, that was lower in individuals below the age of 18 than in adults with a low IFR. As nonpharmaceutical interventions (e.g. social distancing, mask wearing) had already reduced virus spread, mathematical models conclude that the high seroprevalence significantly contributed to the drastic decline of new infections during April.

Covid-19: A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing," by Nevan Krogan, Ph.D., University of California, San Francisco, June 24. This lecture is now archived.

Efforts to develop antiviral drugs versus COVID-19 or vaccines for its prevention have been hampered by limited knowledge of the molecular details of SARS-CoV-2, the virus that causes COVID-19. This webinar will describe Nevan Krogan's efforts to address this challenge. He and his lab expressed 26 of the 29 SARS-CoV-2 proteins in human cells and are using affinity–purification mass spectrometry to identify the human proteins physically associated with each. Among 332 high–confidence SARS-CoV-2-human protein–protein interactions, Krogan's lab has identified 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Within a subset of these, Krogan's lab has used several viral assays to identify two sets of pharmacological agents that displayed antiviral activity.

COVID-19: The Australian Experience and a Perspective Through a SARS-1 Lens


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19: the Australian Experience and a Perspective Through a SARS-1 Lens," by Kanta Subbarao, M.B.B.S., Director of the WHO Collaborating Centre for Reference and Research on Influenza Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia, June 17. This lecture is now archived.

In a few short months, SARS-CoV-2 has swept through the world infecting more than 7 million people and causing more than 400,000 deaths.  However, the pandemic experience and response in different countries around the world has varied.  The peak of the outbreak has passed in Australia, with more than 7,000 cases and more than 100 deaths, but there is a real  possibility of a second wave of infection. The viruses that caused the SARS outbreak of 2002/2003 and the current COVID-19 pandemic are related betacoronaviruses.  Experience with SARS-1 provides some insights into the COVID-19 pandemic.  In this seminar, Dr. Subbarao will discuss the Australian COVID-19 experience and response and will look back on SARS-1 vaccine development for important lessons that can inform SARS-CoV-2 vaccine design, testing, and implementation.

 

Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas

 

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas," by Aviv Regev, Ph.D., Broad Institute, June 3. This lecture is now archived.

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Single-cell analysis of healthy- and SARS-CoV-2-infected tissues offers a unique lens to identify these mechanisms. In an international integrated analysis of the Human Cell Atlas Lung Biological Network--which spans more than 100 single-cell and single-nucleus RNA-Seq datasets previously collected from healthy tissues and includes many previously unpublished studies--we identified the cell types throughout the body most likely to be susceptible to viral entry. In line with epidemiological observations, we also identified increased expression of key mediators of SARS-CoV-2 cellular entry associated with increasing age, male gender, and smoking. In addition, we identified a gene program shared by these cells that includes genes that may mediate viral entry and play key immune roles, such as IL6 and its receptor and co-receptor, IL1R; TNF-response pathways; and complement genes. Following these studies, as the pandemic reached our local Boston community, we have adapted existing sample-processing pipelines with our collaborators in Boston hospitals and are using single-cell and spatial genomics techniques to procure, process, and analyze blood and post-mortem tissue from COVID-19 patients. We are using these pipelines to examine the tissue and immune cellular response to COVID-19, particularly to understand the factors underlying its severity in some individuals, and will share our preliminary results.

 

Structural Studies of Coronavirus Fusion Glycoproteins

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Structural Studies of Coronavirus Fusion Glycoproteins," by David Veesler, Ph.D., Assistant Professor of Biochemistry, University of Washington, May 27. This lecture is now archived.

SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19 pandemic. Coronavirus spike (S) glycoprotein trimers promote the virus’s entry into cells and are the main targets of the humoral immune response. We demonstrated that Angiotensin-converting enzyme 2 (ACE2) is a functional entry receptor for this novel coronavirus and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to ACE2, which correlates with the efficient spread of SARS-CoV-2 among humans. We used cryo-electron microscopy to determine the structures of the SARS-CoV-2 S ectodomain trimer, demonstrating spontaneous opening of the receptor-binding domain, and providing a blueprint for the design of vaccines and inhibitors of viral entry. SARS-CoV S murine polyclonal sera potently inhibited SARS-CoV-2 S-mediated entry into target cells, indicating that vaccination can elicit cross-neutralizing antibodies targeting conserved S epitopes. We subsequently isolated a monoclonal antibody (termed S309) from the memory B cells of an individual who recovered from SARS-CoV in 2003 and showed that S309 potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2. Using cryo-electron microscopy and binding assays, we show that S309 recognizes a receptor-binding domain--glycan-containing epitope, which is conserved within the sarbecovirus subgenus--without competing with receptor attachment. Antibody cocktails including S309 further enhanced SARS-CoV-2 neutralization and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease.

Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic

 

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic," by Tara N. Palmore, M.D., Hospital Epidemiologist, NIH Clinical Center, May 20. This lecture is now archived.

Dr. Palmore will discuss infection control related to COVID-19.  Dr. Palmore began her career at the NIH as a staff clinician in the NIAID Laboratory of Clinical Infectious Diseases.  She became deputy hospital epidemiologist in the NIH Clinical Center in 2007 and became hospital epidemiologist in 2014.  As hospital epidemiologist, Dr. Palmore aims to optimize patient safety through prevention of hospital-acquired infections.  Her research interests include modes of nosocomial transmission of multidrug-resistant bacteria, Clostridium difficile and antimicrobial stewardship.

Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences," by Lori Dodd, Ph.D., Mathematical Statistician, Biostatistics Research Branch, NIAID Division of Clinical Research, May 13. This lecture is now archived.

Designing and implementing clinical trials for novel infectious disease treatments brings many challenges, especially during a rapidly evolving pandemic.  A new disease brings uncertainties arising from an imperfect understanding about illness, limited information about proposed countermeasures, and complexities in measuring relevant patient outcomes.  A pandemic adds an overloaded medical system with limited resources for research, heightened pressure to find cures quickly, and unpredictability about potential case numbers.  I will discuss issues related to designing and conducting treatment trials in outbreaks of Ebola and COVID based on my experience with three studies: Prevail II (the West African Ebola virus disease study of ZMapp), PALM (the Democratic Republic of the Congo Ebola virus disease study of ZMapp, mAb114, REGN-EB3 and remdesivir) and ACTT-1 (the multinational, platform COVID-19 study of remdesivir vs placebo.

Animal Models for COVID-19: A Critical Component of the Response to the Pandemic

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Animal Models for COVID-19: A Critical Component of the Response to the Pandemic," by Emmie de Wit, Ph.D., chief of the NIAID Molecular Pathogenesis Unit, May 6. This lecture is now archived at https://videocast.nih.gov.

We are learning more about different aspects of COVID-19 disease manifestations on an almost daily basis. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models where repeated sampling and tissue collection is possible. Non-human primate models that recapitulate aspects of human disease are essential for our understanding of the pathogenic processes involved in severe respiratory disease and for the development of medical countermeasures such as vaccines and antivirals. We have developed a rhesus macaque model that recapitulates COVID-19 with regard to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions, and seroconversion. These data allow us to bridge between the rhesus macaques model and the disease observed in humans and to use this animal model to assess the efficacy of medical countermeasures. While a large number of investigational, approved, and repurposed drugs have been suggested for the treatment of COVID-19, preclinical data from animal models can guide a more focused search for effective treatments in humans by ruling out treatments that have no proven efficacy in vivo. Remdesivir (GS-5734) is a nucleotide analog prodrug with broad antiviral activity, including against coronaviruses, that is currently being investigated in COVID-19 clinical trials worldwide. The therapeutic efficacy of remdesivir was tested in our rhesus macaque model of COVID-19. Remdesivir treatment initiated early during infection had a clear clinical benefit in SARS-CoV-2-infected rhesus macaques.

COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2


Please join us for "COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2," by Karen Frank, M.D., Ph.D., Chief, Department of Laboratory Medicine, NIH Clinical Center, April 29. This lecture is now archived at https://videocast.nih.gov.

Since the COVID-19 pandemic began, detection of individuals infected with SARS-CoV-2, followed by contact tracing and quarantine, has been critical to slow the spread of disease. After discovery, the coronavirus was sequenced extremely rapidly, and multiple RT-PCR assays were quickly developed and the details shared for use by laboratories worldwide. The molecular assays have excellent performance characteristics with very high sensitivity and specificity. In the United States, the assay designed by the CDC and granted Emergency Use Authorization by the FDA was adopted across the country. In addition, many academic laboratories and commercial manufacturers designed different versions of SARS-CoV-2 tests. The unprecedented need for testing resulted in a severe shortage of all reagents and supplies including collection swabs, transport media, extraction kits, and RT-PCR enzyme mixtures. Creative solutions such as the 3D printing of swabs resulted. A number of studies are underway to determine which specimens (nasopharyngeal, nasal, oropharyngeal, or saliva) are acceptable for testing. Studies that examine viral load from exposure to the end of the disease course are critical for characterizing this sometimes-fatal disease as we work to find treatments. As we develop an algorithm to move out of "stay-at-home lockdown," there is a scramble to develop a high-quality serological assay that would detect neutralizing antibodies.

Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness

Please join us for "Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness," by Barney S. Graham, M.D., Ph.D., deputy director of the NIAID Vaccine Research Center, April 22. This lecture is now archived at https://videocast.nih.gov

The prototype pathogen approach for pandemic preparedness has been applied to the Middle East respiratory syndrome coronavirus (MERS CoV) over the last seven years.  It was informed by structure-based immunogen-design concepts established for respiratory syncytial virus fusion (RSV F) subunit vaccines, and focused on solving coronavirus spike structures, defining mechanisms of CoV neutralization, and evaluating MERS CoV vaccine candidates in collaboration with a commercial mRNA manufacturer.  Prior spike protein engineering experience resulted in rapid sequence selection and using the mRNA manufacturing platform provided rapid Good Manufacturing Practice (GMP) production a COVID-19 mRNA vaccine in record time.  This candidate was tested in mice in approximately 25 days and humans in approximately 65 days from the time the sequence was released.  Clinical and nonclinical evaluation are now proceeding in parallel with hopes to begin efficacy testing before next winter.  The proactive preparation not only facilitated vaccine development but provided a stabilized spike protein reagent that is supporting the development of serological assays.

The Biomedical Research Response to COVID-19: A View from NIAID

Please join us for a special remote lecture, "The Biomedical Research Response to COVID-19: A View from NIAID," by Hilary D.  Marston, M.D., M.P.H., on Wednesday, April 15. This lecture is now archived.

NIAID has a long-standing dual mandate to maintain a robust portfolio of research in its key focus areas and to respond to emerging and re-emerging infectious diseases (EIDs).  With this mandate, NIAID has also sought to improve EID-response preparedness, working in partnership with other U.S.  government research entities, industry, academia, and international public-health organizations.  This preparedness planning helped the institute respond rapidly to COVID-19.  NIAID tapped existing coronavirus expertise and other assets to stand up research programs spanning basic virology and immunology through to countermeasure development (diagnostics, therapeutics, and vaccines).  As the outbreak has expanded, so too has the NIAID research program and the scope of the problems it seeks to solve.  As the COVID-19 pandemic has grown, it has become increasingly clear that the biomedical research response must draw upon the collective expertise of many NIH Institutes and Centers. 


Visit the National Academies Press at https://NAP.edu

 

Airborne Transmission of SARS-CoV-2, Proceedings of a Workshop in Brief, August 2020

Login or register to get access to free PDF downloads of thousands of scientific reports. Examples:

  • How People Learn, Volumes I and II
  • Attribution of Extreme Weather Events in the Context of Climate Change
  • Barriers and Opportunities for 2-year and 4-year STEM Degrees
  • Science, Evolution, and Creationism

Virtual Keystone Symposia

offers free, on-demand and live-streaming of scientific content, highlighting today's breakthroughs in basic research, translational impacts and global health topics. Videos are available on demand after the live sessions.


NIGMS Offerings

 

NIGMS Webinar Series Icon NEW

 

NIGMS is hosting a series of webinars that may be of interest to you/your trainees. The next webinar is Monday, May 11 at 4 PM ET and focuses on "Infectious Disease Modeling Research and the MIDAS Network."  Others topics include "Virtual Teaching and Learning," "Cryo-EM: Present and Future," "Computational Biology and Biomedical Data Science", and "Culturally Aware Practices for Virtual Mentoring, Teaching, and Learning."

See the full list here: 
https://www.nigms.nih.gov/News/meetings/Pages/webinars-for-trainees.aspx
Log in information will be available under the "date" column in the table of topics and speakers.

NIGMS Virtual Learning Resources for Scientists at All Career Stages

To assist with virtual learning during the COVID-19 pandemic, NIGMS has assembled valuable resources to support its trainee and educator communities. These resources apply to all levels, ranging from community college students to faculty.

  • Clearinghouse for Training Modules to Enhance Data Reproducibility
    A variety of free training modules, workshops, and online courses aimed at enhancing rigor and reproducibility in research.
  • iBiology 
    A collection of high-quality, free online videos of scientists talking about their research, career paths, and related topics. Several complete courses are also available in areas including experimental design, microscopy, and image analysis. iBiology also has resources for flipped-classroom teaching.
  • National Research Mentoring Network 
    A free, web-based platform designed to help undergraduates, graduate students, and postdocs connect professionally through online mentoring and networking activities.


NIAID Bioinformatics and Computational Biosciences Branch Presents NIAID BEST: Training Webinars in Times of Teleworking

 

Are your teleworking days giving you some additional flexibility in your schedule? If so, this could be a great opportunity to learn or strengthen your bioinformatics and computational skills! The NIAID Bioinformatics and Computational Biosciences Branch (BCBB) is launching the Bioinformatics Education Support Training (NIAD BEST) program to offer free webinars for all NIH employees over the next few weeks.

In summer 2020, the seminars included:

  • Publishing to NCBI SRA the Easy Way Using METAGENOTE
  • Customizing Your Graphs Using GraphPad Prism 8
  • Practical Training on GraphPad Prism for Statistical Testing - Parts I & II
  • Introduction to UNIX
  • Finding Master Genes Through Gene Regulatory Network Analysis
  • Studying the Microbiome Using the Nephele Web Platform
  • Molecular Visualization with Chimera
  • Preparing and Submitting Protein Structures to the NIAID 3D Printing Service

All webinars were recorded and posted for self-paced learning at https://bioinformatics.niaid.nih.gov/resources.

Contact us at bioinformatics@niaid.nih.gov for questions or suggestions for additional topics.


NIH Library Service


NOTE: Access to some of these resources may be limited to NIH personnel.

Earn Continuing Medical Education (CME) Credits with NIH Library Resources

Did you know that you can earn Continuing Medical Education (CME) credits through resources provided by the NIH Library? NIH staff can earn credits by researching clinical topics and completing evaluations and quizzes while using the resources below.

While on the NIH network, register for a free personal account in each of the following resources. Learn more about how to earn CME credits in each via the CME Information links. Then get started earning CMEs today.

Due to licensing, these resources are only available to NIH staff. New personal accounts must be set up while on the NIH network. For more information, contact Lisa Scanlon, lisa.scanlon@nih.gov


Enhance Your Data Science Skills with the SAGE Data Science Video Collection

Looking to enhance your data science skills this summer? Check out the SAGE Data Science, Big Data Analytics, and Digital Methods video collection made available by the NIH Library. Whether you are just starting out and want to learn how to program in R, or are an expert interested in brushing up on statistics or analytical tools and methods, this video collection can help. The collection is browsable, searchable, and, with an easy-to-create profile, users can save clips, playlists, and searches, and generate alerts. 

These online videos cover a wide range of innovative methods and best practices for data analysis, data visualization, and computational social science research. Over 3,200 videos comprising over 120 hours are available. Example topics include:

  • Programming (Python, R)
  • Data visualization
  • Data management
  • Data and text mining
  • Social media analytics
  • Statistical models and methods
  • Artificial intelligence, machine learning and deep learning
  • Networks and social network analysis
  • Spatial analysis

Check out the Data Science, Big Data Analytics, and Digital Methods video collection and start accelerating your data science training today.

 

NIH Library Online Training Classes for November and December:

January 2021

Jan 27       Introduction to the New EndNote 20 Desktop
Jan 28       Introduction to EndNote Online
Jan 28       Measuring Your Citation Impact
Jan 29       Advanced PubMed
Jan 29       Introduction to UpToDate

February 2021

Feb 1         Types of Literature Reviews
Feb 2         Network Biology Analysis of Omics Data
Feb 3         Introduction to the New EndNote 20 Desktop
Feb 4         Bibliometric Analysis: Using Web of Science and Scopus
Feb 4         Introduction to the Systematic Review Process
Feb 8         Developing and Publishing Your Systematic Review Protocol
Feb 10       Data Wrangling in R
Feb 11       Identifying, Interpreting, and Prioritizing Causal Variants Using QCII-T
Feb 11       Developing the Research Question and Conducting the Literature Search
Feb 11       Introduction to the New EndNote 20 Desktop
Feb 16       Exploring the Cochrane Library
Feb 17       Introduction to the New EndNote 20 Desktop
Feb 17       Gray Literature: Searching Beyond Databases
Feb 18       Screening Best Practices and Managing Your Data for Systematic Reviews
Feb 18       Introduction to PubMed
Feb 19       Advanced PubMed
Feb 24       Using Endnote for Systematic Reviews
Feb 25       Getting Your Systematic Review Written and Published
Feb 25       Introduction to Adobe Premiere Pro
Feb 25       Introduction to the New EndNote 20 Desktop
Feb 26       Introduction to UpToDate

March

Mar 2         Bulk RNA-Seq Data Analysis in Partek Flow
Mar 3         Variant Selection in Genomics DNA Sequences
Mar 4         Single Cell RNA-Seq Data Analysis in Partek Flow
Mar 5         ATAC-Seq/ChIP-Seq Data Analysis in Partek Flow
Mar 12       Bibliometric Analysis Using InCites
Mar 15       Exploring the Cochrane Library: Systematic Reviews, Clinical Trials, and More
Mar 18       Data Management and Sharing: Part 1
Mar 19       Data Management and Sharing: Part 2
Mar 24       Introduction to Artificial Intelligence and Machine Learning

NIH Library Online Training Classes

 

The NIH Library Training Program is a premier provider of information and data management training for the NIH intramural research community. NIH Library classes are free, available to NIH and select HHS staff, and are currently being offered entirely online via WebEx. All sessions are taught by dedicated subject matter experts including NIH Library staff, guest instructors, and industry experts.

The NIH Library Training Program also offers on-demand, online tutorials to accommodate self-paced learning. For personalized instruction, schedule an individual or group consultation with one of our information experts.

NIH Library staff are available for ongoing support and help with research questions, specific training needs, or with follow-up questions after classes.

Full-text online journals, the library catalog, and information about Library resources and services are available on the Library's website: https://nihlibrary.nih.gov. For more information, contact the Library at 301-496-1080 or nihlibrary@nih.gov.

To stay up to date on NIH Library classes, events, resources, and services, subscribe to our e-news.

The NIH Library serves the information needs of NIH staff and select Department of Health and Human Services agencies. The NIH Library is part of the Office of Research Services in the Office of the Director.

Online Services, Training, and Resources from the NIH Library

The NIH Library is here to help you—online—with your teleworking information and research needs. This week, we are sharing top-level online services, training, and resources available from the NIH Library. In the coming weeks, we will feature additional online offerings under each of these main areas. 

Services

  • Ask A Question: contact us with your information questions
  • Get Help: use our “get help” forms to request materials, suggest a resource, get editing assistance, and more (most of our library services remain available during this time)
  • Find Your Librarian: contact your librarian for personalized assistance—each Institute or Center has their own dedicated informationist or specialized librarian

Training

  • Training classes: sign up for online classes in bioinformatics, databases, technology, writing and publishing, and other topics
  • Consultations: contact us to get personalized help with using our resources, conducting a systematic review, getting help with your bioinformatics questions, and more
  • Tutorials: check out our collection of on-demand, online tutorials which are ideal for self-paced learning 

Resources

  • Journals: access over 12,000 online current and historical journals, most with complete archives
  • eBooks: extend your research with our collection of over 160,000 scholarly eBooks
  • Databases: search over 50 reference databases including PubMed@NIH, Web of Science, Scopus, and UpToDate

NIH staff can access these online resources via the NIH VPN, or by logging in through the NIH Library’s remote access service. Eligible HHS employees should connect through the remote access service. 

Contact us today for assistance with your information and research needs. ___________________________

The NIH Library
301-496-1080
nihlibrary@nih.gov

3D Printing Medical Supplies: A Web Guide from the NIH Library

During the COVID-19 pandemic, “makers” have come together to design, 3D print, and distribute medical supplies. In support of this effort, staff from the NIH Library Technology Hub Team collected and consolidated information about making personal protective equipment, or PPE, in a helpful web guide.

This page will be updated regularly with information about federal guidelines, maker initiatives, scholarly research, and NIH’s involvement. Please note that this is for informational purposes only; the NIH Library does not endorse any plans, models, or organization shared in this guide.

For questions or suggestions about this web guide contact Alicia Lillich, alicia.lillich@nih.gov.


Experience Science in Action with JoVE Science Education Videos


JoVE Science Education videos
help you and your lab stay up to date on scientific fundamentals with easy-to-follow video demonstrations created by experts at top institutions. The videos can accelerate learning and improve lab productivity; use them to help train new employees, increase retention of techniques and concepts through the video transcripts, reduce time needed to learn new methods, and improve overall productivity and reproducibility.

The videos cover a wide range of subjects, including basic and advanced science topics, lab safety, and scientific and research methods. The NIH Library provides access to selected collections, which are available to NIH staff:

Check out the JoVE video collections today and experience science in action.