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Other Learning Opportunities for Stay-at-home Scientists

NLM/MLA Leiter Lecture - Dr. John Brownstein on Digital Epidemiology and the COVID-19 Pandemic - August 11, 2020 – 6:00 PM (EDT) Icon NEW

Inside the Coronavirus: Special Coverage from Scientific American, fantastic graphics that explain what scientists know now about SARS-CoV-2 now and will be updated as we learn more Icon NEW

NINR Artificial Intelligence Virtual Boot Camp Icon NEW

Public Health Mitigation of COVID-19: An Adherence Challenge – July 29 webinar Icon NEW

ABRCMS (The Annual Biomedical Research Conference for Minority Students) has created ABRCMS Online Icon NEW

NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”, June 24

When Public Health Means Business: A Harvard T.H. Chan School of Public Health / New England Journal of Medicine Virtual Symposium: Part 4, August 5, 1:00 - 2:00 pm EDT Icon NEW

Health Disparities & Obesity Webinar: May 28, 2020

NCATS Online Course in Translational Science: June - July, 2020

Supporting People with Addiction During COVID-19: A webinar series from the National Academy of Medicine

NIH Office of Behavioral and Social Sciences Research presentation: "What are we learning from talking to scientists about scientific communication?" May 19, 2020, 2:00 - 3:00 pm EDT

The Forum: Harvard T.H. Chan School of Public Health. A series of 18 (and counting) panel discussions on the Coronavirus Pandemic.

National Academy of Sciences COVID-19 Update

Earth Day Activities: August 22

Virtual Radcliffe Discussion Series: Health Inequity in the Age of COVID-19

1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

NLM Research Symposium: Reporting, Recording, and Remembering the 1918 Influenza Epidemic

NCI Bioinformatics Training and Education Program's Single Cell RNA-Seq Virtual Town Halls, July 23 and 30 Icon NEW

PBS Film: “Ken Burns presents The Gene: An Intimate History”, now available for streaming

NIH Begins Study to Quantify Undetected Cases of Coronavirus Infection (read the article)

New Science Webinar from AAAS: Coronavirus: A Survival Guide (now available on demand)

FAES Offerings: An Afternoon with an NIH PI, a lecture series

NIH COVID-19 Lecture Series Icon NEW

Visit the National Academies Press to Download FREE PDFs of Their Reports

Virtual Keystone Symposia: The Malaria Endgame (4/22) Earlier sessions are available on demand.

NIGMS Training Offerings: NIGMS Virtual Learning Resources AND Webinar Series  Icon NEW

NIAID Bioinformatics and Computational Biosciences Branch Webinars

NIH LIBRARY SERVICES: NIH Library Online Training Classes AND Other Online Services, Training, and Resources, A Web Guide on 3D Printing Medical Supplies; Courses for August and September; JoVE Science Education Videos; Enhance Your Data Science Skills with the SAGE Data Science Video Collection Icon NEW


NLM/MLA Leiter Lecture - Dr. John Brownstein on Digital Epidemiology and the COVID-19 Pandemic - August 11, 2020 – 6:00 PM (EST)

The National Library of Medicine (NLM) and the Medical Library Association (MLA) are hosting the Leiter Lecture presented by Dr. John Brownstein on Digital Epidemiology and the COVID-19 Pandemic on Tuesday, August 11, 2020 from 6:00 – 7:00 PM (EST) by videocast.

John S. Brownstein is professor of biomedical informatics at Harvard Medical School and is the chief innovation officer of Boston Children’s Hospital. He also directs the Computational Epidemiology Lab and the Innovation and Digital Health Accelerator, both at Boston Children’s Hospital. Brownstein is also Uber’s health care advisor and cofounder of the digital health companies Epidemico and Circulation. He will be speaking on the surveillance, control, and prevention of disease, the development and application of data mining, and citizen science to public health in relation to his work with the COVID-19 pandemic.

This lecture will be streamed and archived by NIH Video Casting: https://videocast.nih.gov/watch=38269

If you have any questions about the lecture, please contact Patricia Gallagher at patricia.gallagher@nih.gov or Stacey Arnesen at stacey.arnesen@nih.gov.

Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact NLM Communications at NLMCommunications@nih.gov and/or the Federal Relay at 1-800-877-8339.  Requests should be made five days in advance.


NINR Artificial Intelligence Virtual Boot Camp

In August, the National Institute of Nursing Research (NINR) will hold a four-day virtual boot camp to explore the impact that Artificial Intelligence (AI) has in the evolving healthcare environment, and overall efforts to improve the quality of care for patients and families. The goal is to enable attendees to understand basic principles of AI and how clinicians can form strategic alliances with data scientists to carry out research on data-driven intelligent hardware and software approaches to health-related issues. The event will be broadcast live via VideoCast and archived for later viewing.

August 3-6, 2020   |   Noon-2:10 p.m. (EDT)

Register for this event: http://ow.ly/BDHp50ArNVb *Continuing Education Units (CEUs) will be available for attending this event.

Objectives:

  • Describe the field of Artificial Intelligence (AI) and explore the role of AI to promote health, and to prevent illness.
  • Discuss strategies to build partnerships and collaborations among clinicians and scientists.
  • Explore AI data collection, including ethical, legal, and social implications.
  • Analyze clinical and translational AI applications that can reach more diverse patient populations and improve the safety, efficacy, and quality of healthcare.

Boot Camp Agenda:

  • [8/3/2020] Session I: Innovations and Improvements in Health Outcomes
  • [8/4/2020] Session II: Clinical Applications
  • [8/5/2020] Session III: Ethical, Legal, And Social Implications
  • [8/6/2020] Session IV: Collaborative Science

Learn more and view the full event agenda at: www.ninr.nih.gov/bootcamp2020

To request reasonable accommodations, please contact precious.enyidah@nih.gov at least five days before the event. Real-time captioning will be available via VideoCast by pressing the CC icon on the video player.

 


Public Health Mitigation of COVID-19: An Adherence Challenge – July 29 Webinar

The NIH Adherence Network Distinguished Speakers program is hosting a webinar:

Public Health Mitigation of COVID-19: An Adherence Challenge
William T. Riley, Ph.D., Director, NIH Office of Behavioral and Social Sciences
Wednesday, July 29  1:00-2:00 p.m. ET
WebEx only

Register here: https://cbiit.webex.com/cbiit/onstage/g.php?MTID=ec06429ae0a263a31ab007b6a2f79f3e7  

The mitigation of the COVID-19 pandemic requires that nearly all of the population follow various public health recommendations including handwashing, social distancing, wearing facial coverings, etc. Although adherence research has focused primarily on medication adherence, there is a considerable literature, including from prior infectious disease epidemics, on how to facilitate adherence to public health behaviors for the current pandemic emergency. This research can guide public health officials in methods to increase adherence to the recommendations. The current pandemic also highlights gaps in our understanding of public health adherence, and further research from this pandemic will improve our response to future public health crises.

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in this event should contact Sharon McCarthy, NCI Healthcare Delivery Research Program,  sharon.mccarthy@nih.gov, 240-276-5546 and/or the Federal Relay(1-800-877-8339)  Requests should be made two business days in advance of the webinar.


ABRCMS (The Annual Biomedical Research Conference for Minority Students) has created ABRCMS Online Icon NEW

ABRCMS Online is an extension of the conference that allows the biomedical sciences community to continue learning, with resources for students, trainees, faculty, and community.


NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”

The first lecture in NLM’s Ada Lovelace Computational Health Lecture Series "AI in the Age of COVID-19: Computational Tools for a Pandemic”, will be presented Wednesday, June 24, 2020 | 1:00pm to 2:00pm | NIH Videocast

The talk will be delivered by Dr. John H. Holmes, PhD, FACE, FACMI, FIAHSI, Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Perelman School of Medicine.

Traditional methods of epidemic modeling continue to be used fruitfully for characterizing outbreaks and predicting the spread of disease in populations. However, these methods, typically rely on what are known as “compartment models”, requiring assumptions that are not necessarily sensitive to the ever-changing environmental, behavioral, temporospatial, and social phenomena that influence disease spread. Compartment models can be enriched by the judicious use of robust methods drawn from the field of artificial intelligence that allow us to model more accurately and more quickly the population and disease dynamics that are central to developing policies for prevention, detection, and treatment. We will explore these approaches, including some that are currently in use as well as a proposal for novel, next-generation machine learning tools for epidemiologic investigation.

John H. Holmes, PhD, is Professor of Medical Informatics in Epidemiology at the University of Pennsylvania Perelman School of Medicine. He is the Associate Director of the Penn Institute for Biomedical Informatics and is Past-Chair of the Graduate Group in Epidemiology and Biostatistics. Dr. Holmes has been recognized nationally and internationally for his work on developing and applying new artificial intelligence approaches to mining epidemiologic surveillance data.  Dr. Holmes’ research interests are focused on the intersection of medical informatics and clinical research, specifically evolutionary computation and machine learning approaches to knowledge discovery in clinical databases, deep electronic phenotyping, interoperable information systems infrastructures for epidemiologic surveillance, and their application to a broad array of clinical domains, including cardiology and pulmonary medicine. He has served as the co-lead of the Governance Core for the SPAN project, a scalable distributed research network, and participates in the FDA Sentinel Initiative. Dr. Holmes is an elected Fellow of the American College of Medical Informatics (ACMI), the American College of Epidemiology (ACE), and the International Academy of Health Sciences Informatics Medical Informatics (ACMI), the American College of Epidemiology (ACE), and the International Academy of Health Sciences Informatics (IAHSI).

This lecture is sponsored by Valerie Florance, PhD, Associate Director of the National Library of Medicine, Division of Extramural Programs and Dr. Milton Corn, MD, Acting Scientific Director, National Library of Medicine

This lecture will be live-streamed globally, and subsequently archived, by NIH video casting: https://videocast.nih.gov/watch=37909

Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact Valerie Bartlett, bartletv@mail.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.

Submit questions during the meeting to: NLMEPInfo@mail.nih.gov.


When Public Health Means Business: A Harvard T.H. Chan School of Public Health / New England Journal of Medicine Virtual Symposium, Part 4, August 5, 1:00 - 2:00 pm EDT Icon NEW

 

Dr. Anthony Fauci, the nation’s top infectious disease specialist, will answer questions from Harvard Chan faculty and other COVID-19 experts, going narrow and deep on questions about the pandemic that you won’t hear anywhere else. The session will be moderated by Dr. Sanjay Gupta, Chief Medical Correspondent for CNN.

“When Public Health Means Business” is a multi-part series that virtually convenes luminaries from the realms of finance, industry and health to map a new path forward and ensure a better, safer future for all. Jointly presented by the Harvard T.H. Chan School of Public Health and the New England Journal of Medicine, and hosted by The Forum at the Harvard T.H. Chan School of Public Health.

The first three sessions are available on demand, below.

Part 1: The current COVID-19 pandemic has revealed a plain truth: We can no longer afford to operate in silos. Instead, this once-in-a-lifetime public health crisis demands a remarkable level of cooperation across sectors and disciplines. Now more than ever, public health and business need to forge ahead together to clear the runway for our economy and society to thrive.

What will it take to move forward globally? How do we battle the war against science? What will it take to succeed? How can we prepare now for the next pandemic?

In Part 2, we will build on that framework, examining how the value created by public health is equal to if not greater than the shareholder value created in business; how are businesses to function while waiting for COVID-19 vaccines and treatments; and should we consider privatizing the public health system?

In Part 3, the series continues with a dynamic discussion between Lawrence H. Summers, President Emeritus and Charles W. Eliot University Professor at Harvard University, and Stephanie Ruhle, NBC News Business Correspondent and Host of 'MSNBC Live'. They will examine how and why the public health and business sectors must engage for the economy and society to thrive now and well after the COVID-19 pandemic. 


Health Disparities & Obesity Webinar: May 29, 2020

An NIH Obesity Research Task Force Seminar Series presentation:

HEALTH DISPARITIES & OBESITY
Thursday, May 28, 2020
1:00 p.m. - 3:00 p.m.
Register for the webinar at the link below

https://cbiit.webex.com/cbiit/onstage/g.php?MTID=eed9688006d8d1c0f09e3027f685e7d46 

“Obesity in Hispanics/Latinos: Insights into the Intersection of Socio-cultural Factors and Genomics”
Carmen R. Isasi, MD, PhD, FAHA
Albert Einstein College of Medicine

“Neighborhood Environment as a Social Determinant of Obesity – Lessons Learned Through Community Engagement”
Tiffany M. Powell-Wiley, MD, MPH, FAHA
National Heart, Lung, and Blood Institute

“Digital Interventions for High-Risk Underserved Populations with Diabetes and Pre-diabetes”
Athena Philis-Tsimikas, MD
Scripps Whittier Diabetes Institute

Individuals with disabilities who need closed captioning to participate in this event should contact Jaime Smith, PhD, at Jaime.smith@nih.gov and/or the Federal Relay (1-800-877-8339).


NCATS Online Course in Translational Science: June - July, 2020

Enhance your translational science skills this summer with a seven-week online course designed by the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).

The course — MEDI 501: Principles of Preclinical Translational Science — is offered by NCATS in partnership with the Foundation for Advanced Education in the Sciences (FAES), which is located at the NIH.

Translational science is an emerging field that seeks to identify broadly generalizable scientific and operational principles to enhance the effectiveness and efficiency of translational research.

In this course, students will learn preclinical translational science principles. Faculty will teach these principles through a case study of a highly successful translational research partnership involving NCATS, the National Cancer Institute, Northwestern University and the University of Kansas. The partnership produced a promising potential drug shown to inhibit metastasis in animal models, which is being examined in a first-in-human clinical trial in 2020.

The course is relevant to individuals in a range of roles — including scientists, administrators and experts in scientific collaboration — and is appropriate across all career stages, from students to senior scientists.

This one-credit course requires a time commitment of about one hour per week to listen to course lectures, plus time to complete course readings and other short assignments.

Because this is a pilot course, it is being offered at a reduced fee of only $50.

To learn more, please go to https://ncats.nih.gov/events#online-course, where you’ll be able to view the course syllabus and speakers, as well as a course flyer (attached) with more information.

Registration is now open.

Go to https://faes.org/courses and locate the course title – MEDI 501: Principles of Preclinical Translational Science.  If you are new to FAES, you will need to click on the “Login” button in the right hand corner of the page, then click on “Applicant Portal Homepage” and then click on “Create a New Account” and complete the form.  There is a short wait time after submitting the form while FAES reviews the information submitted.  After this review, the account will be activated and the prospective student will receive an email with the subject heading “Welcome to FAES” and will be able to register for MEDI501.

Please contact Jessica Faupel-Badger, PhD, MPH (badgerje@mail.nih.gov) or Amanda Vogel, PhD, MPH (amanda.vogel@nih.gov) at the NCATS Education Branch with any questions about the format or content of the course.


 

Supporting People with Addiction During COVID-19: A webinar series from the National Academy of Medicine

Individuals experiencing addiction are a vulnerable population that have been significantly impacted by the COVID-19 pandemic. Physical distancing protocols have separated patients from their clinicians, made medications to treat addiction much more challenging to obtain, and shuttered many long-term recovery groups. 

A new webinar series from the NAM and the American Society of Addiction Medicine will provide insight and targeted guidance on how to ensure that these individuals are cared for and protected during this ongoing public health crisis.

Webinar 1: Helping People with Addiction Stay Connected during COVID-19. Available as a video recording.


NIH Office of Behavioral and Social Sciences Research presentation: "What are we learning from talking to scientists about scientific communication?" May 19, 2020, 2:00 - 3:00 pm EDT

Register: https://obssr.od.nih.gov/what-we-are-learning-from-talking-to-scientists-about-science-communication .

Presentation Overview:

In recent years, Dr. John Besley has shifted his research from the study of public opinion about science to trying to understand scientists' opinion about the public.

As part of this work, he and his collaborators have advanced a framework for strategic science communication that emphasizes setting clear behavioral goals and then working backwards to identify communication objectives that have the potential of affecting desired behaviors, as well as tactics to help achieve the communication objectives. This perspective puts identifying and prioritizing specific communication objectives at the core of being an effective communicator.

Dr. Besley will share his thinking along with selected data from his surveys and interviews of scientists.

John Besley, Ph.D., is Ellis N. Brandt Professor of Public Relations at Michigan State University.

The recording of this webinar will be available with closed captioning on OBSSR’s website approximately two weeks following the webinar: https://obssr.od.nih.gov/what-we-are-learning-from-talking-to-scientists-about-science-communicatio.


The Forum: Harvard T.H. Chan School of Public Health. A series of 18 panel discussions (and counting) on the Coronavirus Pandemic

https://theforum.sph.harvard.edu/series/covid-19/

Email your questions to theforum@hsph.harvard.edu or post them to Facebook @ForumHSPH or @pritheworld.

Did You Miss Some? Watch These and More On Demand:

The Coronavirus Pandemic: Equity, Impacts and Global Fragile Communities (August 11th, noon, EDT)

#First RespondersFirst: The Path Forward (July 29)

The Coronavirus Pandemic: Unequal Risks for Communities of Color (July 21st)

The Coronavirus Pandemic: Advances in Testing, Fighting the Surge (July 14th)

The Coronavirus Pandemic: Surging Cases, A Growing Crisis (July 7th)

Food Insecurity, Inequality, and COVID-10 (June 30)

The Coronavirus Pandemic: What's Next? with Caroline Buckee (June 23)

Racism and COVID-19, with David Harris, (June 18)

The Coronavirus Pandemic: Stopping the Spread of Misinformation, with K. "Vish" Vishwanath (May 26)

The Coronavirus Pandemic: Responding Now and Averting Future Crises, with Howard Koh (May 19)

The Coronavirus Pandemic: Antibody Testing and Reopening Society, with Dr. Michael Mina (May 15)

The Coronavirus Pandemic: Safely Opening Workplaces, with Dr. Joseph Allen (May 12, 2020)

The Coronavirus Pandemic: Potential Vaccines and Treatments, with Dr. Barry Bloom (May 7, 2020)

The Coronavirus Pandemic: Mental Health, Stress and Resiliency, with Karestan Koenen (May 5, 2020)

Voices in Leadership During Crises: Stephanie Ferguson (April 30, 2020)

The Coronavirus Pandemic: Health Inequities and Vulnerable Communities, with Mary Bassett (April 28, 2020)

COVID-19: Where do we go from here?, Presented jointly by the Harvard T.H. Chan School of Public Health and the New England Journal of Medicine (April 21, 2020)

The Coronavirus Pandemic: Hospital Frontlines During the Surge, with Paul Biddinger (April 16, 2020)


National Academy of Sciences COVID-19 Update

Saturday, April 25, 2020
2:00 p.m. EDT

  •  Jeremy Farrar, Director, Wellcome Trust (confirmed)
  •  Anthony S. Fauci, Director, National Institute of Allergy and Infectious Diseases (accepted, schedule permitting)
  •  George F. Gao, Director-General, Chinese Center for Disease Control & Prevention (confirmed)
  •  Susan R. Weiss, Professor of Microbiology, Perelman School of Medicine, University of Pennsylvania (confirmed)
  •  Richard J. Hatchett, CEO, Coalition for Epidemic Preparedness Innovations (confirmed)
  •  Sanjay Gupta, Chief Medical Correspondent, CNN (confirmed)

http://www.nasonline.org/about-nas/events/annual-meeting/nas157/covid19-update.html


Earth Day Activities: It's the 50th Anniversary! August 22

 

March for Science: Flatten the Curve Forum - April 22, 2020, 8:30am - 6:00pm

Agenda:

https://mcusercontent.com/411a4f036b04a4b0a416702e2/images/c14e93c5-64cc-451e-b68b-fffd669c8ca8.png?mc_cid=4e465fdd89&mc_eid=5907627ca4

To Register:

https://www.eventbrite.com/e/earth-week-2020-march-for-science-media-zone-registration-101821675372?mc_cid=4e465fdd89&mc_eid=5907627ca4

The March for Science Media Zone April 22-26, 2020 in honor of the 50th Anniversary of Earth Day. Streaming Live on facebook.com/marchforscience.

New Documentary on the Discovery Channel: The Story of Plastic

The new documentary The Story of Plastic premieres on Discovery Network channels around the world Friday, April 22nd, Earth Day!

The Story of Plastic takes a sweeping look at the global plastic pollution crisis and how it’s affecting the health of our planet and people around the world; it’s also a story of hope, featuring the heroes who are bringing meaningful solutions to life all along the plastics supply chain.

Discovery Channel Premiere

The Story of Plastic will air on Discovery Network channels in 134 countries and territories around the world over the coming weeks.

In the United States, the movie will premiere on April 22nd at 2pm Eastern and Pacific. Please check your local listings for broadcast information and visit storyofplastic.org/watch for more information. 

 


Virtual Radcliffe Discussion Series: Health Inequity in the Age of COVID-19

 
The Radcliffe Institute is launching a new Virtual Radcliffe programming platform to offer lectures and conferences that connect leading scholars and practitioners with the public and advance discourse on pressing issues. Beginning on Thursday, April 23, Radcliffe will host a series of discussions examining the grave health inequities revealed and exacerbated by COVID-19, which is disproportionately impacting vulnerable and marginalized communities. The first event in our series will examine health equity in the context of disability.

We look forward to continuing to share announcements about upcoming virtual events in our e-newsletters throughout the remainder of the semester and summer months. You can also check our website for a list of programs.

State Prisons and COVID-19 Icon NEW

Wednesday, May 6, 1 PM
Register

How should directors of state prison systems respond to the current pandemic? Patricia Caruso and Harold Clarke will draw on their decades of experience to address the particular challenges posed by COVID-19. They will consider possible solutions, including steps to protect both the incarcerated population and staff, repurposing prison garment shops to produce protective gear for people on the front lines, and responsible early release—all with the aim of contributing to lasting public safety.

Health, Inequity, and COVID-10 Icon NEW

April 28, 2020
Recordings of prior sessions will be posted approx. 2 weeks after the events.

International experience in recent months has powerfully illustrated that the COVID-19 virus has particularly harmful and disproportionate effects on already vulnerable populations. Mary Bassett and Khalil Gibran Muhammad will discuss inequity and public health in the time of COVID-19, exploring how the virus encounters existing inequalities, replicates these inequalities, and, in many cases, amplifies them.

Ensuring Health Equity for Persons with Disabilities: The Context and Ethics of Health Rationing Protocols during COVID-19

Thursday, April 23, 4 PM
Recordings of prior sessions will be posted approx. 2 weeks after the events

As COVID-19 threatens to push hospital resources beyond capacity, states, hospitals, and advocacy organizations have formulated protocols to address potential discrimination against persons with disabilities. Highly influential statements by the Arc and the University of Pittsburgh are setting new standards for the ethical treatment of persons with disabilities. This Radcliffe webinar places these triaging policies within the context of the history of disability civil rights, culture, and bioethics and considers what is necessary to achieve equitable health outcomes for persons with disabilities during this time of crisis.


1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

https://www.youtube.com/watch?v=UDY5COg2P2c&feature=emb_rel_end

Historical documentary about 1918 Swine Flu or Spanish Flu and the role of World War I in spreading the disease among troops making it into a worldwide plague of devastating proportions. The video covers where it began, how and where it spread, the symptoms, how it affected America and whether it could happen again.


NLM Research Symposium: Reporting, Recording, and Remembering the 1918 Influenza Epidemic

The symposium will be held virtually on Wednesday, April 29, 2020, 2:00-4:00pm ET, via streamlined Webex to reduce bandwidth usage, while being livestreamed and subsequently archived by NIH Videocasting as part of its archive of past NLM history of medicine events.

Watch and hear the program via this URL: https://videocast.nih.gov/watch=36347

Join us to learn the research outcomes of Virginia Tech students studying the history of data in social context through individual and collaborative primary-source research here at the NLM and elsewhere, and as part of their course Topics in the History of Data in Social Context, being taught by Dr. E. Thomas Ewing.

During the symposium, the students will present their research on various aspects of the 1918 pandemic, including newspaper reporting at the peak of the epidemic (late September to early November 1918), contemporary social distancing policies and procedures, and how contemporaries determined that the epidemic was ending, and how they remembered the remarkable experience of this intense, but relatively brief, crisis in community health.

Discussants will include Dr. Nancy Bristow of the University of Puget Sound and author of American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford University Press, 2012), among others to be announced.

All are welcome to tune-in to this research symposium which advances the NLM 2017-2027 strategic plan emphasizing data-driven discovery, enhanced stakeholder engagement, and the role of libraries and archives in providing trusted information.

Reporting, Recording, and Remembering the 1918 Influenza Epidemic is sponsored by the NLM History of Medicine Division in cooperation with the National Endowment (NEH) for the Humanities Office of Digital Humanities—as part of the ongoing NLM/NEH partnership to collaborate on research, education, and career initiatives.

Individuals with disabilities who need sign language interpreting and/or other reasonable accommodations to participate in this event should contact Dr. Stephen Greenberg at greenbes@mail.nlm.nih.gov and/or the Federal Relay at 1-800-877-8339. Requests should be made five days in advance.


NCI Bioinformatics Training and Education Program Virtual Town Halls: Ask Your Single Cell RNA-Seq Questions: July 23 and 30

In May, the NIH Library Bioinformatics Support Program presented a Single Cell Sequencing Bioinformatics Workshop. The workshop generated a lot of interest and follow-up questions. This month, our Bioinformatics Team is following up the workshop by coordinating with the NCI CCR Bioinformatics Training and Education Program (BTEP) to present two virtual town halls on the topic of single cell sequencing. The town halls will be held online on July 23 and July 30, 10:00 a.m. to 12:00 p.m.

This is a great opportunity to get your single cell sequencing questions answered. See below for the official announcement and registration information, along with a link to submit questions which will be addressed during the town halls. Please note that questions must be submitted by July 15 to be included in the town hall discussions.

*********************

The NCI CCR Bioinformatics Training and Education Program (BTEP), in conjunction with the NIH Library and the CCR Single Cell Analysis Facility (SCAF), announces a series of virtual “Single Cell” town halls.

Get your questions answered about single cell RNA-seq experimental design and data analysis by a panel of scientists with expertise in these techniques. You can submit questions to https://btep.ccr.cancer.gov/question/single_cell_rna_seq/. Your questions will be answered during two live webinars on July 23 and July 30.

For more information and to register for the events:  

Individuals with disabilities who need Sign Language Interpreters and/or reasonable accommodation to participate in these events should contact Amy Stonelake, amy.stonelake@nih.gov, (240)760-6314, and/or the Federal Relay (1-800-877-8339). Such requests should be made at least two business days in advance of either event. 


PBS Film: “Ken Burns presents The Gene: An Intimate History” -- aired April 7 & 14. You can now stream it from https://www.pbs.org/kenburns/the-gene/.

 

A new PBS film, “Ken Burns presents The Gene: An Intimate History,” based on the book by Dr. Siddhartha Mukherjee, will air in two parts: tomorrow, April 7 at 8 pm ET and next Tuesday, April 14 at 8 pm ET.  Dr. Mukherjee shared his insights on the book with NIH staff in April 2017 as part of the NIH Big Read series (https://videocast.nih.gov/summary.asp?live=21833&bhcp=1).

For more than two years, the National Human Genome Research Institute (NHGRI) has been proud to support the education and outreach associated with this film, and the NIH Office of the Director, the National Institute of General Medical Sciences, and others across NIH have also contributed substantially.

The film describes the history of genetics, from Mendel to modern day. It brings to life the story of today’s revolution in medical science through present-day tales of patients and doctors at the forefront of the search for genetic treatments, interwoven with a compelling history of the discoveries that made this possible and the ethical challenges raised by the ability to edit DNA with precision.

The filmmakers interviewed many NIH staff and NIH-funded researchers in making the documentary, and you will see multiple NIH employees featured in the final cut. For example, Dr. Francis Collins and I were given the opportunity to recount the excitement of the Human Genome Project and its incredible legacy, including the birth of NHGRI and the increased investments in genetics and genomics by all parts of NIH.


New Science Webinar from AAAS: Coronavirus: A Survival Guide

Thursday, 16 April 2020, 11 a.m. Eastern, 8 a.m. Pacific, 4 p.m. UK (BST), 5 p.m. Central Europe (CEST)
Now available on demand.

  • What the coronavirus is and how it makes you sick
  • What you can do to protect yourself, and keep your friends and family safe
  • How you can build resilience to deal with this new way of life
  • What the end of this pandemic might look like 
  • Where you can get the latest information about the virus that is accurate and trustworthy.

FAES Offerings

 
An afternoon with an NIH PI, a new lecture series hosted by FAES Icon NEW

 
We are excited to announce a new virtual lecture series called “An afternoon with an NIH PI” during May 2020 in which prominent scientists from the NIH will share their latest research and insights into their career path. Attendees will be able to submit questions during and after the seminar via chat, and those will be discussed at the end of the seminar. Recordings of all the lectures are now available at https://faes.org/content/an-afternoon-with-an-NIH-PI.

  1. A Drug's Purpose: From ED to Viral Hepatitis to COVID-19
    Jake Liang​, MD | NIH Distinguished Investigator, Chief, Liver Diseases Branch, NIDDK

  2. Role of the Microbiota in Immunity and Repair
    Yasmine Belkaid, PhD​ | Chief, Metaorganism Immunity Section, NIAID

  3. Big-Small, Tall-Short, Big Ears-Little Ears: What is the Genetics of it All?
    Elaine Ostrander, PhD | NIH Distinguished Investigator, Cancer Genetics and Comparative Genomics Branch, NHGRI
     
  4. Self-Renewal, Differentiation and Transformation in Hematopoiesis and in Science
    Cynthia Dunbar, MD | Chief, Translational Stem Cell Biology Branch, NHLBI
     
  5. From Axon Damage to Disease: Common Pathways in Neurodegeneration
    Claire Le Pichon, PhD | Investigator, Unit on the Development of Neurodegeneration, NICHD

  6. scRNAseq Developmental Trajectories to Investigate Differentiation
    Jeff Farrell, PhD | Earl Stadtman Investigator, Unit on Cell Specification and Differentiation, NICHD

  7. Biological Imaging at High Spatiotemporal Resolution (and How I Got into This)
    Hari Shroff, PhD | Senior Investigator, Laboratory of High Resolution Optical Imaging, NIBIB

FAES Online Summer Courses

The summer semester will run from June 15th - July 31st and all courses will be taught online.  Tuition per course ranges from $160 - $640, depending on course credit hours.

Virtual Information Session Registration:  https://faes.org/events/faes-virtual-information-session 

Course Registration:  https://faes.org/courses

BIOF439 Data Visualization with R
BIOL102 Foundations in Biomedical Sciences II
ENGL355 Advanced English Conversation: Language, Culture, and Medicine
ENGL365 Writing for Your Audience
GENL319 MCAT Review and Test Preparation
GENL322 GRE Review
IMMU369 Epidemics, Vaccines, and Prevention
IMMU403 Basic Principles of Immunology and Hypersensitivity
MICR325 Molecular Microbiology
PBHL402 Social Determinants of Health
PBHL537 Health Policy Analysis Using SAS and STATA
PHAR402 Drug Transport
STAT200 Experimental Statistics I
TECH490 Communication in Biomedical Sciences

If you have any questions, please email registrar@faes.org or call 301-496-7976.

Individuals with disabilities who need reasonable accommodation to take FAES classes should contact registrar@faes.org. Requests should be made at least five days in advance.

FAES Online Bioinformatics Workshops

FAES@NIH is pleased to offer virtual hands-on workshops in a variety of bioinformatics subjects (NGS data analysis, R, Python, Linux, MATLAB, etc.) in April, May, and June 2020                                                      

Rosetta for Molecular Modeling and Design: Hands-on Training (6/22 - 6/25)

To register or for more information, visit our website: https://faes.org/workshops-conferences, email registrar@faes.org, or call 301-496-7977. 


NIH COVID-19 Lecture Series

SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects," by Alessandro Sette, Ph.D., professor and member of the La Jolla Institute for Immunology, La Jolla, Calif.

This lecture will be on Wednesday, July 29, from 3:00 to 4:00 p.m. ET via https://videocast.nih.gov.  Please see viewing instructions below.  This lecture will be the last talk in the COVID-19 lecture series for two months.  We will resume in October.   

Lecture summary:

For his lecture, Dr. Sette will review data examining the nature and specificity of T cell responses to SARS-CoV-2 from convalescent and acute donors, and in non-exposed subjects.  Over the past three decades, the Sette lab has defined in chemical terms the specific structures that the immune system recognizes, and it has capitalized on this knowledge to measure and understand immune responses.  This approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology.  Turning to SARS-CoV-2, Dr. Sette and his colleagues applied this approach to provide the one of the first assessments of whether the immune system can mount a substantial and lasting response, finding evidence of T cell reactivity against and pre-existing immunity to SARS-CoV-2.  Dr. Sette will highlight these and other findings in his talk.

This lecture will be videocast live and quickly archived at https://videocast.nih.gov.  To watch live, we suggest that you have Adobe Flash Player installed on your computer and that your web browser of choice can access Flash. 

If you cannot log on because of the high demand, please note that the archive will be available within two days.

Sign-language interpreters can be provided.  Individuals with disabilities who need reasonable accommodation to participate in this event should contact Karen Nemes, nemesk@od.nih.gov, or the Federal Relay, 800-877-8339.

 

COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far," by Stefania Pittaluga, M.D., and David Kleiner, M.D., Ph.D., senior research physicians in the NCI-CCR Laboratory of Pathology, July 22. This lecture is now archived.

Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published.  Although most patients experience mild symptoms, some have serious complications—including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia—that contribute to the high mortality rate.  Autopsies can offer a better understanding of the underlying pathophysiology.  Unfortunately few autopsies were performed early in the pandemic because of the potential risks.  Untreated patients who died of SARS-CoV-2 were rarely autopsied.  Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs.  We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH.  We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.

Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Nucleic Acid Delivery Systems for RNA Therapy and Gene Editing," by Dan Anderson, Ph.D., professor of chemical engineering and of health sciences and technology at the MIT Koch Institute for Integrative Cancer Research, July 15. This lecture is now archived.

High–throughput, combinatorial approaches have revolutionized small-molecule drug discovery.  Dan Anderson will describe his work on the combinatorial development of nanoparticulate, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized, formulated, and screened for their ability to deliver macromolecular payloads inside of cells.  These nanoformulations facilitate in vivo delivery, enabling gene suppression with small-interfering RNA, gene expression with messenger RNA, or permanent genetic editing using the CRISPR/Cas9 system.  Formulations have been developed with in vivo efficacy and show potential therapeutic applications for a range of different diseases.  This lecture will focus on the application of these formulations toward controlling the immune system and in particular as vaccines for infectious disease.

 

Lessons Learned: Management and Treatment during COVID-19 Pandemic

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Lessons Learned: Management and Treatment during COVID-19 Pandemic," by Judith A. Aberg, M.D., chief of Infectious Diseases, Icahn School of Medicine at Mount Sinai, and a member of the panel developing NIH COVID-19 Treatment Guidelines, July 8. This lecture is now archived.

Dr. Aberg will briefly discuss what is new in the pathogenesis of SARS-CoV-2 and how this affected the decision-making processes on the management and treatment of SARS-CoV-2 infection during the COVID-19 pandemic in New York City. Even in the absence of data and insufficient knowledge of what may or may not work, the Mount Sinai Health System created treatment guidelines that were updated frequently based on physicians' observations and information gathered from multiple disciplines across the system. Dr. Aberg will present a few lessons learned that affected the quality-of-care of patients. The majority of her talk will focus on how clinical observations at the Mount Sinai Health System and how social media and knowledge imparted from colleagues across the globe influenced clinical decision making. Dr. Aberg will close the talk with a summary of how she and her colleagues are better prepared for the future, the knowledge they have gained, and the potential therapeutic options currently under investigation.

High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "High Seroprevalence, Drastic Decline of Incidence and Low Infection Fatality Rate of SARS-CoV-2 Infections in Children and Adults in the Ski Resort Ischgl, Austria," by Dorothee von Laer, M.D., Medical University of Innsbruck, July 1. This lecture is now archived.

In early March 2020, a SARS-CoV-2 outbreak at a ski resort in Ischgl, Austria, initiated the spread of SARS-CoV-2 throughout Austria and Northern Europe. Thousands of infections can be traced back to Ischgl. In a recent study by Medical University of Innsbruck investigators, 42.4 percent of those living in Ischgl were shown to be carrying the new coronavirus antibodies, indicating they had been infected in the COVID-19 pandemic. Between April 21 and 27, a cross-sectional epidemiologic study targeting the full population of Ischgl (n= app. 1,867), of which 79 percent could be included (n=1473), was performed. For each individual, the study involved a SARS-CoV-2 PCR test for the virus, antibody testing, and a questionnaire. In addition, the SARS-CoV-2 PCR+ cases reported to the authorities were included. The seroprevalence was 42 percent and individuals under 18 showed a significantly lower seroprevalence (27 percent) than adults (45 percent). However, only 105 study participants remembered if they had a previous positive PCR result. The clinical course was generally mild and only two individuals in Ischgl had died from infection corresponding to an infection fatality rate (IFR) of 0.26 percent. In the first week of April, a public screening in Ischgl had found 19 percent of the population to be PCR+. However, only 8 (0.5 percent) individuals were newly diagnosed to be infected with SARS-CoV-2 during the study conducted 2-3 weeks later.  Ischgl was hit early and hard by SARS-CoV-2, which led to a high local seroprevalence of 42 percent, that was lower in individuals below the age of 18 than in adults with a low IFR. As nonpharmaceutical interventions (e.g. social distancing, mask wearing) had already reduced virus spread, mathematical models conclude that the high seroprevalence significantly contributed to the drastic decline of new infections during April.

Covid-19: A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing," by Nevan Krogan, Ph.D., University of California, San Francisco, June 24. This lecture is now archived.

Efforts to develop antiviral drugs versus COVID-19 or vaccines for its prevention have been hampered by limited knowledge of the molecular details of SARS-CoV-2, the virus that causes COVID-19. This webinar will describe Nevan Krogan's efforts to address this challenge. He and his lab expressed 26 of the 29 SARS-CoV-2 proteins in human cells and are using affinity–purification mass spectrometry to identify the human proteins physically associated with each. Among 332 high–confidence SARS-CoV-2-human protein–protein interactions, Krogan's lab has identified 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Within a subset of these, Krogan's lab has used several viral assays to identify two sets of pharmacological agents that displayed antiviral activity.

COVID-19: The Australian Experience and a Perspective Through a SARS-1 Lens


The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "COVID-19: the Australian Experience and a Perspective Through a SARS-1 Lens," by Kanta Subbarao, M.B.B.S., Director of the WHO Collaborating Centre for Reference and Research on Influenza Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia, June 17. This lecture is now archived.

In a few short months, SARS-CoV-2 has swept through the world infecting more than 7 million people and causing more than 400,000 deaths.  However, the pandemic experience and response in different countries around the world has varied.  The peak of the outbreak has passed in Australia, with more than 7,000 cases and more than 100 deaths, but there is a real  possibility of a second wave of infection. The viruses that caused the SARS outbreak of 2002/2003 and the current COVID-19 pandemic are related betacoronaviruses.  Experience with SARS-1 provides some insights into the COVID-19 pandemic.  In this seminar, Dr. Subbarao will discuss the Australian COVID-19 experience and response and will look back on SARS-1 vaccine development for important lessons that can inform SARS-CoV-2 vaccine design, testing, and implementation.

 

Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas

 

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Toward Understanding COVID-19 Infection, Transmission, and Pathogenesis at Single-Cell Resolution with the Human Cell Atlas," by Aviv Regev, Ph.D., Broad Institute, June 3. This lecture is now archived.

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Single-cell analysis of healthy- and SARS-CoV-2-infected tissues offers a unique lens to identify these mechanisms. In an international integrated analysis of the Human Cell Atlas Lung Biological Network--which spans more than 100 single-cell and single-nucleus RNA-Seq datasets previously collected from healthy tissues and includes many previously unpublished studies--we identified the cell types throughout the body most likely to be susceptible to viral entry. In line with epidemiological observations, we also identified increased expression of key mediators of SARS-CoV-2 cellular entry associated with increasing age, male gender, and smoking. In addition, we identified a gene program shared by these cells that includes genes that may mediate viral entry and play key immune roles, such as IL6 and its receptor and co-receptor, IL1R; TNF-response pathways; and complement genes. Following these studies, as the pandemic reached our local Boston community, we have adapted existing sample-processing pipelines with our collaborators in Boston hospitals and are using single-cell and spatial genomics techniques to procure, process, and analyze blood and post-mortem tissue from COVID-19 patients. We are using these pipelines to examine the tissue and immune cellular response to COVID-19, particularly to understand the factors underlying its severity in some individuals, and will share our preliminary results.

 

Structural Studies of Coronavirus Fusion Glycoproteins

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Structural Studies of Coronavirus Fusion Glycoproteins," by David Veesler, Ph.D., Assistant Professor of Biochemistry, University of Washington, May 27. This lecture is now archived.

SARS-CoV-2 is a newly emerged coronavirus responsible for the current COVID-19 pandemic. Coronavirus spike (S) glycoprotein trimers promote the virus’s entry into cells and are the main targets of the humoral immune response. We demonstrated that Angiotensin-converting enzyme 2 (ACE2) is a functional entry receptor for this novel coronavirus and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to ACE2, which correlates with the efficient spread of SARS-CoV-2 among humans. We used cryo-electron microscopy to determine the structures of the SARS-CoV-2 S ectodomain trimer, demonstrating spontaneous opening of the receptor-binding domain, and providing a blueprint for the design of vaccines and inhibitors of viral entry. SARS-CoV S murine polyclonal sera potently inhibited SARS-CoV-2 S-mediated entry into target cells, indicating that vaccination can elicit cross-neutralizing antibodies targeting conserved S epitopes. We subsequently isolated a monoclonal antibody (termed S309) from the memory B cells of an individual who recovered from SARS-CoV in 2003 and showed that S309 potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2. Using cryo-electron microscopy and binding assays, we show that S309 recognizes a receptor-binding domain--glycan-containing epitope, which is conserved within the sarbecovirus subgenus--without competing with receptor attachment. Antibody cocktails including S309 further enhanced SARS-CoV-2 neutralization and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease.

Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic

 

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic," by Tara N. Palmore, M.D., Hospital Epidemiologist, NIH Clinical Center, May 20. This lecture is now archived.

Dr. Palmore will discuss infection control related to COVID-19.  Dr. Palmore began her career at the NIH as a staff clinician in the NIAID Laboratory of Clinical Infectious Diseases.  She became deputy hospital epidemiologist in the NIH Clinical Center in 2007 and became hospital epidemiologist in 2014.  As hospital epidemiologist, Dr. Palmore aims to optimize patient safety through prevention of hospital-acquired infections.  Her research interests include modes of nosocomial transmission of multidrug-resistant bacteria, Clostridium difficile and antimicrobial stewardship.

Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Clinical Trials in Public Health Emergencies: the Ebola and COVID Experiences," by Lori Dodd, Ph.D., Mathematical Statistician, Biostatistics Research Branch, NIAID Division of Clinical Research, May 13. This lecture is now archived.

Designing and implementing clinical trials for novel infectious disease treatments brings many challenges, especially during a rapidly evolving pandemic.  A new disease brings uncertainties arising from an imperfect understanding about illness, limited information about proposed countermeasures, and complexities in measuring relevant patient outcomes.  A pandemic adds an overloaded medical system with limited resources for research, heightened pressure to find cures quickly, and unpredictability about potential case numbers.  I will discuss issues related to designing and conducting treatment trials in outbreaks of Ebola and COVID based on my experience with three studies: Prevail II (the West African Ebola virus disease study of ZMapp), PALM (the Democratic Republic of the Congo Ebola virus disease study of ZMapp, mAb114, REGN-EB3 and remdesivir) and ACTT-1 (the multinational, platform COVID-19 study of remdesivir vs placebo.

Animal Models for COVID-19: A Critical Component of the Response to the Pandemic

The NIH COVID-19 Scientific Interest Group is pleased to announce its next lecture, "Animal Models for COVID-19: A Critical Component of the Response to the Pandemic," by Emmie de Wit, Ph.D., chief of the NIAID Molecular Pathogenesis Unit, May 6. This lecture is now archived at https://videocast.nih.gov.

We are learning more about different aspects of COVID-19 disease manifestations on an almost daily basis. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models where repeated sampling and tissue collection is possible. Non-human primate models that recapitulate aspects of human disease are essential for our understanding of the pathogenic processes involved in severe respiratory disease and for the development of medical countermeasures such as vaccines and antivirals. We have developed a rhesus macaque model that recapitulates COVID-19 with regard to virus replication and shedding, the presence of pulmonary infiltrates, histological lesions, and seroconversion. These data allow us to bridge between the rhesus macaques model and the disease observed in humans and to use this animal model to assess the efficacy of medical countermeasures. While a large number of investigational, approved, and repurposed drugs have been suggested for the treatment of COVID-19, preclinical data from animal models can guide a more focused search for effective treatments in humans by ruling out treatments that have no proven efficacy in vivo. Remdesivir (GS-5734) is a nucleotide analog prodrug with broad antiviral activity, including against coronaviruses, that is currently being investigated in COVID-19 clinical trials worldwide. The therapeutic efficacy of remdesivir was tested in our rhesus macaque model of COVID-19. Remdesivir treatment initiated early during infection had a clear clinical benefit in SARS-CoV-2-infected rhesus macaques.

COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2


Please join us for "COVID-19 Diagnostics: The Challenge of Rapid, High-Volume Detection of SARS-CoV-2," by Karen Frank, M.D., Ph.D., Chief, Department of Laboratory Medicine, NIH Clinical Center, April 29. This lecture is now archived at https://videocast.nih.gov.

Since the COVID-19 pandemic began, detection of individuals infected with SARS-CoV-2, followed by contact tracing and quarantine, has been critical to slow the spread of disease. After discovery, the coronavirus was sequenced extremely rapidly, and multiple RT-PCR assays were quickly developed and the details shared for use by laboratories worldwide. The molecular assays have excellent performance characteristics with very high sensitivity and specificity. In the United States, the assay designed by the CDC and granted Emergency Use Authorization by the FDA was adopted across the country. In addition, many academic laboratories and commercial manufacturers designed different versions of SARS-CoV-2 tests. The unprecedented need for testing resulted in a severe shortage of all reagents and supplies including collection swabs, transport media, extraction kits, and RT-PCR enzyme mixtures. Creative solutions such as the 3D printing of swabs resulted. A number of studies are underway to determine which specimens (nasopharyngeal, nasal, oropharyngeal, or saliva) are acceptable for testing. Studies that examine viral load from exposure to the end of the disease course are critical for characterizing this sometimes-fatal disease as we work to find treatments. As we develop an algorithm to move out of "stay-at-home lockdown," there is a scramble to develop a high-quality serological assay that would detect neutralizing antibodies.

Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness

Please join us for "Rapid COVID-19 Vaccine Development: An Example of the Prototype Pathogen Approach for Pandemic Preparedness," by Barney S. Graham, M.D., Ph.D., deputy director of the NIAID Vaccine Research Center, April 22. This lecture is now archived at https://videocast.nih.gov

The prototype pathogen approach for pandemic preparedness has been applied to the Middle East respiratory syndrome coronavirus (MERS CoV) over the last seven years.  It was informed by structure-based immunogen-design concepts established for respiratory syncytial virus fusion (RSV F) subunit vaccines, and focused on solving coronavirus spike structures, defining mechanisms of CoV neutralization, and evaluating MERS CoV vaccine candidates in collaboration with a commercial mRNA manufacturer.  Prior spike protein engineering experience resulted in rapid sequence selection and using the mRNA manufacturing platform provided rapid Good Manufacturing Practice (GMP) production a COVID-19 mRNA vaccine in record time.  This candidate was tested in mice in approximately 25 days and humans in approximately 65 days from the time the sequence was released.  Clinical and nonclinical evaluation are now proceeding in parallel with hopes to begin efficacy testing before next winter.  The proactive preparation not only facilitated vaccine development but provided a stabilized spike protein reagent that is supporting the development of serological assays.

The Biomedical Research Response to COVID-19: A View from NIAID

Please join us for a special remote lecture, "The Biomedical Research Response to COVID-19: A View from NIAID," by Hilary D.  Marston, M.D., M.P.H., on Wednesday, April 15. This lecture is now archived.

NIAID has a long-standing dual mandate to maintain a robust portfolio of research in its key focus areas and to respond to emerging and re-emerging infectious diseases (EIDs).  With this mandate, NIAID has also sought to improve EID-response preparedness, working in partnership with other U.S.  government research entities, industry, academia, and international public-health organizations.  This preparedness planning helped the institute respond rapidly to COVID-19.  NIAID tapped existing coronavirus expertise and other assets to stand up research programs spanning basic virology and immunology through to countermeasure development (diagnostics, therapeutics, and vaccines).  As the outbreak has expanded, so too has the NIAID research program and the scope of the problems it seeks to solve.  As the COVID-19 pandemic has grown, it has become increasingly clear that the biomedical research response must draw upon the collective expertise of many NIH Institutes and Centers. 


Visit the National Academies Press at https://NAP.edu

 

Login or register to get access to free PDF downloads of thousands of scientific reports. Examples:

  • How People Learn, Volumes I and II
  • Attribution of Extreme Weather Events in the Context of Climate Change
  • Barriers and Opportunities for 2-year and 4-year STEM Degrees
  • Science, Evolution, and Creationism

Virtual Keystone Symposia

offers free, on-demand and live-streaming of scientific content, highlighting today's breakthroughs in basic research, translational impacts and global health topics. Videos are available on demand after the live sessions.

Register to hear from global research leaders about new directions in biomedical research and innovation, from cancer immunotherapy to advances in vaccinology, bioinformatics tools and more.

The Malaria Endgame

 

Date: April 22, 2020
Time: 12:00PM - 01:30PM
You must be registered to participate!

Covering the current state of the field, and future directions and challenges in the fight to eliminate malaria from endemic countries, this ePanel will highlight various aspects of disease prevention, treatment and control, including:

  • current state of vaccine
  • impact of co-infections in Africa
  • genetically modified mosquitos-benefits, risks and community engagement challenges
  • the disconnect between research and malaria control programs

NIGMS Offerings

 

NIGMS Webinar Series Icon NEW

 

NIGMS is hosting a series of webinars that may be of interest to you/your trainees. The next webinar is Monday, May 11 at 4 PM ET and focuses on "Infectious Disease Modeling Research and the MIDAS Network."  Others topics include "Virtual Teaching and Learning," "Cryo-EM: Present and Future," "Computational Biology and Biomedical Data Science", and "Culturally Aware Practices for Virtual Mentoring, Teaching, and Learning."

See the full list here: 
https://www.nigms.nih.gov/News/meetings/Pages/webinars-for-trainees.aspx
Log in information will be available under the "date" column in the table of topics and speakers.

NIGMS Virtual Learning Resources for Scientists at All Career Stages

To assist with virtual learning during the COVID-19 pandemic, NIGMS has assembled valuable resources to support its trainee and educator communities. These resources apply to all levels, ranging from community college students to faculty.

  • Clearinghouse for Training Modules to Enhance Data Reproducibility
    A variety of free training modules, workshops, and online courses aimed at enhancing rigor and reproducibility in research.
  • iBiology 
    A collection of high-quality, free online videos of scientists talking about their research, career paths, and related topics. Several complete courses are also available in areas including experimental design, microscopy, and image analysis. iBiology also has resources for flipped-classroom teaching.
  • National Research Mentoring Network 
    A free, web-based platform designed to help undergraduates, graduate students, and postdocs connect professionally through online mentoring and networking activities.


NIAID Bioinformatics and Computational Biosciences Branch Presents NIAID BEST: Training Webinars in Times of Teleworking

 

Are your teleworking days giving you some additional flexibility in your schedule? If so, this could be a great opportunity to learn or strengthen your bioinformatics and computational skills! The NIAID Bioinformatics and Computational Biosciences Branch (BCBB) is launching the Bioinformatics Education Support Training (NIAD BEST) program to offer free webinars for all NIH employees over the next few weeks.

A webinar schedule has been posted on the bioinformatics @NIAID portal (https://bioinformatics.niaid.nih.gov). Topics include genomics, structural biology, programming, and more. When you visit the Events page of the portal, select the webinar title and register for the GoToWebinar. GoToWebinar will send you a customized link, so registration is required. 

For ease of search, the titles of the seminars scheduled to-date are:

  • Publishing to NCBI SRA the Easy Way Using METAGENOTE
  • Customizing Your Graphs Using GraphPad Prism 8
  • Practical Training on GraphPad Prism for Statistical Testing - Parts I & II
  • Introduction to UNIX
  • Finding Master Genes Through Gene Regulatory Network Analysis
  • Studying the Microbiome Using the Nephele Web Platform
  • Molecular Visualization with Chimera
  • Preparing and Submitting Protein Structures to the NIAID 3D Printing Service

If you are unable to attend, all webinars will be recorded and posted for self-paced learning.

Contact us at bioinformatics@niaid.nih.gov for questions or suggestions for additional topics.


NIH Library Service


Enhance Your Data Science Skills with the SAGE Data Science Video Collection

Looking to enhance your data science skills this summer? Check out the SAGE Data Science, Big Data Analytics, and Digital Methods video collection made available by the NIH Library. Whether you are just starting out and want to learn how to program in R, or are an expert interested in brushing up on statistics or analytical tools and methods, this video collection can help. The collection is browsable, searchable, and, with an easy-to-create profile, users can save clips, playlists, and searches, and generate alerts. 

These online videos cover a wide range of innovative methods and best practices for data analysis, data visualization, and computational social science research. Over 3,200 videos comprising over 120 hours are available. Example topics include:

  • Programming (Python, R)
  • Data visualization
  • Data management
  • Data and text mining
  • Social media analytics
  • Statistical models and methods
  • Artificial intelligence, machine learning and deep learning
  • Networks and social network analysis
  • Spatial analysis

Check out the Data Science, Big Data Analytics, and Digital Methods video collection and start accelerating your data science training today.

 

NIH Library Online Training Classes: June and July 2020

NIH Library August and September classes are now available for registration. All classes are being offered online via WebEx. Descriptions and registration are available through the links below.

August

Aug 5           Introduction to Adobe Photoshop
Aug 6           VSClinical for American College of Medical Genetics and Genomics Guidelines
Aug 6           Biosketch: Telling Your Research Stories
Aug 10         VarSeq Copy Number Variation Caller and Golden Helix CancerKB for AMP Workflow
Aug 11         Introduction to R Data Types
Aug 12         Introduction to Web of Science
Aug 12         Introduction to PubMed
Aug 13         Searching Smarter: Keeping Current in the Literature
Aug 14         Using VSClinical for Association for Molecular Pathology Guidelines
Aug 14         Introduction to Taxonomies
Aug 18         Tips for the Path to Publishing Success
Aug 20         SNP and Variation Suite for Genome-Wide Association Studies
Aug 26         Introduction to EndNote Online
Aug 27         Web Searching: Thinking Beyond Google
Aug 28         Introduction to EndNote Desktop
Aug 28         Pathway Analysis

September

Sept 2          Variant Selection in Genomics DNA Sequences
Sept 2          Introduction to the Systematic Review Process
Sept 3          Types of Literature Reviews: Selecting the Most Appropriate Review for Your Research
Sept 8          Genome Browser
Sept 9          Developing and Publishing Your Systematic Review Protocol
Sept 9          Bibliometric Analysis Using InCites
Sept 10        Developing the Research Question and Conducting the Literature Search
Sept 14        Gray Literature
Sept 15        Screening Best Practices and Managing Your Data for Systematic Reviews
Sept 16        Introduction to Scopus
Sept 16        Using Endnote for Systematic Reviews
Sept 16        Introduction to PubMed
Sept 17-18   Data Management and Sharing (Two-Part Course)
Sept 22        Writing and Publishing Your Systematic Review
Sept 23        MetaCore Introductory Training
Sept 24        MetaCore Advanced Session
Sept 25        Introduction to Taxonomies
Sept 25        NCI Cancer Research Data Commons: Cloud Computing
Sept 29        Meta-Analysis: Quantifying a Systematic Review
Sept 30        Introduction to EndNote Desktop
Sept 30        Introduction to EndNote Online

July 27        Information Resources for Clinical Research
July 28        Copyright and Plagiarism: What Authors Need to Know
July 29        Statistical Considerations in Preparing Your Manuscript
July 30        Introduction to EndNote Online

 

NIH Library Online Training Classes

 

The NIH Library Training Program is a premier provider of information and data management training for the NIH intramural research community. NIH Library classes are free, available to NIH and select HHS staff, and are currently being offered entirely online via WebEx. All sessions are taught by dedicated subject matter experts including NIH Library staff, guest instructors, and industry experts.

The NIH Library Training Program also offers on-demand, online tutorials to accommodate self-paced learning. For personalized instruction, schedule an individual or group consultation with one of our information experts.

NIH Library staff are available for ongoing support and help with research questions, specific training needs, or with follow-up questions after classes.

Full-text online journals, the library catalog, and information about Library resources and services are available on the Library's website: https://nihlibrary.nih.gov. For more information, contact the Library at 301-496-1080 or nihlibrary@nih.gov.

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The NIH Library serves the information needs of NIH staff and select Department of Health and Human Services agencies. The NIH Library is part of the Office of Research Services in the Office of the Director.

Online Services, Training, and Resources from the NIH Library

The NIH Library is here to help you—online—with your teleworking information and research needs. This week, we are sharing top-level online services, training, and resources available from the NIH Library. In the coming weeks, we will feature additional online offerings under each of these main areas. 

Services

  • Ask A Question: contact us with your information questions
  • Get Help: use our “get help” forms to request materials, suggest a resource, get editing assistance, and more (most of our library services remain available during this time)
  • Find Your Librarian: contact your librarian for personalized assistance—each Institute or Center has their own dedicated informationist or specialized librarian

Training

  • Training classes: sign up for online classes in bioinformatics, databases, technology, writing and publishing, and other topics
  • Consultations: contact us to get personalized help with using our resources, conducting a systematic review, getting help with your bioinformatics questions, and more
  • Tutorials: check out our collection of on-demand, online tutorials which are ideal for self-paced learning 

Resources

  • Journals: access over 12,000 online current and historical journals, most with complete archives
  • eBooks: extend your research with our collection of over 160,000 scholarly eBooks
  • Databases: search over 50 reference databases including PubMed@NIH, Web of Science, Scopus, and UpToDate

NIH staff can access these online resources via the NIH VPN, or by logging in through the NIH Library’s remote access service. Eligible HHS employees should connect through the remote access service. 

Contact us today for assistance with your information and research needs. ___________________________

The NIH Library
301-496-1080
nihlibrary@nih.gov

3D Printing Medical Supplies: A Web Guide from the NIH Library

During the COVID-19 pandemic, “makers” have come together to design, 3D print, and distribute medical supplies. In support of this effort, staff from the NIH Library Technology Hub Team collected and consolidated information about making personal protective equipment, or PPE, in a helpful web guide.

This page will be updated regularly with information about federal guidelines, maker initiatives, scholarly research, and NIH’s involvement. Please note that this is for informational purposes only; the NIH Library does not endorse any plans, models, or organization shared in this guide.

For questions or suggestions about this web guide contact Alicia Lillich, alicia.lillich@nih.gov.


Experience Science in Action with JoVE Science Education Videos


JoVE Science Education videos
help you and your lab stay up to date on scientific fundamentals with easy-to-follow video demonstrations created by experts at top institutions. The videos can accelerate learning and improve lab productivity; use them to help train new employees, increase retention of techniques and concepts through the video transcripts, reduce time needed to learn new methods, and improve overall productivity and reproducibility.

The videos cover a wide range of subjects, including basic and advanced science topics, lab safety, and scientific and research methods. The NIH Library provides access to selected collections, which are available to NIH staff:

Check out the JoVE video collections today and experience science in action.