Postdoctoral Fellow

Our laboratory develops curative strategies for sickle cell disease, β-thalassemia, and other inherited blood disorders. We use CRISPR-Cas9, base editing, prime editing, and emerging genome engineering technologies to achieve these aims. Prospective postdoctoral candidates will participate in highly-translational projects spanning from mechanistic studies to preclinical evaluations of clinically-relevant animal models.

Our current research areas include:

• CRISPR-Cas9, base editing, and prime editing of human hematopoietic stem and progenitor cells (HSPCs)
• The development of novel editing strategies for fetal hemoglobin reactivation and mutation correction
• The optimization of genome editing efficiency, precision, and long-term stem cell function
• The functional assessment of edited HSPCs using in vitro differentiation, colony assays, and transplantation models
• The evaluation of genome-editing outcomes using molecular and genomic analyses, including next-generation sequencing and off-target assessment
• The translation of genome-editing approaches into mouse xenograft and nonhuman primate transplantation models

Prospective applicants should have a Ph.D., M.D., or an equivalent doctoral degree received within the past 5 years, or otherwise expect to receive their degree within the next 6 months, in molecular biology, genetics, stem cell biology, biomedical engineering, immunology, and/or a related field.

Experience in CRISPR genome editing, Mammalian cell culture, hematopoietic stem cell biology, Flow cytometry, and/or cell sorting is welcome, as is expertise in performing general molecular biology techniques. Experience with animal models of hematopoiesis and/or Bioinformatics and next-generation sequencing analysis is also highly-desirable.

The ideal candidate will be motivated, intellectually curious, and passionate about developing innovative genome editing therapies with direct translational and clinical relevance. This position offers opportunities to collaborate with leading investigators across the NIH, academia, and industry, as well as present research at national and international conferences. Candidates can also expect to publish in high-impact scientific journals and contribute to projects that advance towards clinical translation.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.