Job
Postdoctoral Fellow
Organization
National Institute of Allergy and Infectious Diseases, Bethesda, MD and surrounding area
Scientific focus area
Computational Biology, Genetics and Genomics, Immunology, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry
The Antibody Biology Unit in the NIAID Laboratory of Immunogenetics, headed by Dr. Joshua Tan, is seeking a Postdoctoral Fellow to establish a novel antibody discovery platform using next-generation sequencing, micro-fluidics, and library display.
About the position
Monoclonal antibodies are powerful tools for the treatment of infectious and immunological disease. The Antibody Biology Unit in the NIAID Laboratory of Immunogenetics aims to discover therapeutic monoclonal antibodies to combat major pathogens, including malaria, TB and infectious viruses.
Specifically, the Tan Lab has recently identified rare monoclonal antibodies that target the malaria parasite (Dacon et al., Science 2025; Wang et al., Cell 2024), as well as broadly neutralizing antibodies that fight against coronaviruses (Dacon et al., Science 2022), both of which are leading candidates for clinical development. However, even the most advanced methods for antibody discovery are labor- and time-intensive.
Recent advances in library display, microfluidics and next-generation sequencing have provided promising tools to construct large-scale antibody panels that can be willingly screened for potent neutralizing antibodies against any target of interest. Yet, this potential has not yet been realized with the construction of a workable platform that fully utilizes these developments.
As such, we are now seeking a postdoctoral fellow to develop a new method of antibody discovery that is substantially faster than our existing methods. This position is ideal for a candidate, with a strong genome-sciences or molecular-biology background, who is interested in making a real-world impact on how we prevent and treat disease.
Additionally, the NIH Intramural program provides excellent training and career development opportunities. Trainees will receive health insurance as well as a stipend commensurate with experience.
Apply for this vacancy
What you'll need to apply
Interested candidates should send a cover letter, current curriculum vitae, and three letters of reference to Dr. Joshua Tan at the email below.
Contact name
Joshua Tan
Contact email
Qualifications
Prospective candidates must have a Ph.D. in genome sciences, molecular biology, or biochemistry, or a relevant field, experience in next-generation sequencing, including barcode demultiplexing and association with protein variants, experience in bioinformatics, particularly in analysis of complex genetic datasets, and a track record of scientific publication and willingness to collaborate and work as part of a team.
Disclaimer/Fine Print
U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.
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