Postdoctoral Fellow (AD/FTD Organoids)

Our lab's research is centered on exploring the intricacies of neuronal vulnerability and the toxicity of non-neuronal cells in TDP-43 proteinopathies, which include Alzheimer's disease and Frontotemporal Dementia. Prospective postdocs will use iPSC-derived brain cells and organoids, as well as organotypic slice cultures, to explore non-neuronal cell interactions during disease onset and progression. They will do so by leveraging a range of complementary approaches, including multi-omics (proteomics, single-cell and spatial transcriptomics, and long-read sequencing), histology, advanced microscopy, genetic engineering tool and electrophysiology. This postdoctoral researcher will also collaborate with other intramural NIH labs, extramural labs, and be supported by CARD mentors and expert groups.

Applications are invited from individuals with an expertise in neurobiology, neuropathology, cell biology, molecular biology, and bioinformatics. Ideally, candidates should hold a PhD or MD/PhD. Previous experience in iPSC culture or organotypic slice culture is highly recommended, and skills in bioinformatics (scRNAseq, spatial omics analysis, R, Python) would be a plus.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.