Postdoctoral Fellow

This postdoctoral fellowship, under Dr. Stefania Dell’Orso, is ideal for candidates interested in pursuing technology-driven careers in industry, biotech, or advanced research infrastructure. This position will include mentored hands-on experience with a broad spectrum of next-generation sequencing and multi-omics technologies. Potential candidates will work at the interface of technology development, experimental design, and bioinformatics analysis in a highly collaborative environment, with opportunities to lead independent projects in support of immunology, metabolism, transcriptional control, skin, musculoskeletal and auto-immune disorders research.

This is a full-time position with an initial appointment of one year, renewable annually, up to 5 total years. The NIH offers a competitive salary and comprehensive health insurance. The NIH is also dedicated to the continued education and career development of all its research staff, including opportunities to attend and present at national and international scientific meetings.

Key Responsibilities of this position include:

• Conducting library preparation, experimental design, and sequencing & data analysis in collaboration with investigators, including the selection of platforms, assay types, and depth/coverage considerations aligned with scientific projects.
• Optimizing sequencing libraries for short-read platforms (Illumina MiSeq, NextSeq 2000, NovaSeq X Plus) and long-read sequencing (Oxford Nanopore).
• Operating and maintaining cutting-edge instruments to ensure high-quality data generation.
• Performing bioinformatics analyses of sequencing data (not limited to QC), including processing, integration, and interpretation of bulk and single-cell datasets.
• Contributing to the development, optimization, and interpretation of omics-data across Single-Cell Genomics Applications.
• Designing and executing single-cell experiments using 10x Genomics, Takara ICELL8, and plate-based approaches.
• Applying a wide range of assays including scRNA-seq, scATAC-seq, scCUT&Tag, CITE-seq, CRISPR-based screens, scTCR, and scBCR.
• Performing and supporting spatial transcriptomics workflows using Xenium, Visium HD, and emerging platforms (e.g. Atera).
• Other processes include ChIP-seq CUT&Tag, CUT&RUN Hi-C, Whole Genome Sequencing, and Whole Exome Sequencing.

Prospective applicants should have a Ph.D. in molecular biology, genomics, biotechnology, or a related field, as well as experience with NGS library preparation or genomics assays. They should also have an interest in technology development, platforms, and applied genomics. Strong organizational and collaborative skills are required.

This position is particularly well-suited for candidates who enjoy working with evolving technologies, supporting diverse scientific projects, and building deep technical expertise, and who are considering careers in industry, core facilities, or advanced research environments.

Candidates are subject to a background investigation. U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.