Postdoctoral fellow

A postdoctoral position is available in the Metabolism, Genes, and Environment Group at the National Institute of Environmental Health Sciences (NIEHS), a major research institute of the NIH located in the research triangle park of North Carolina. NIEHS offers an outstanding research environment and has been constantly rated by The Scientist as one of the best places to work.

The long-term goal of the research group is to understand how cellular metabolism mediates environmental influences on cellular functions through interaction with epigenetic modification enzymes, and to further investigate how dysregulation of this interplay contributes to pathogenesis of diseases and aging. To achieve this goal, the group has two major research directions. The first direction is focused on SIRT1, a highly conserved NAD+-dependent protein deacetylase/deacylase important for epigenetic and transcriptional regulation of gene expression. Utilizing mice and culture cells as model systems, our group combines molecular, cellular, and genetic approaches to study the role of metabolism, SIRT1, and protein acetylation/acylation in mediating environmental influence on aging, development, and metabolic diseases. The second direction aims to understand the impact of dietary methionine restriction, a dietary regimen that is known to protect against metabolic diseases and aging, on cancer and anti-cancer immunity. The current research areas include host-microbe interaction in host NAD+ metabolism and related (patho)physiology; host regulation of gut microbiota in intestinal tissue homeostasis, inflammation, and tumorigenesis; metabolic and epigenetic regulation of stem cell functions and tumorigenesis. For more information, please visit: https://www.niehs.nih.gov/research/atniehs/labs/stl/pi/metabolism/index.cfm.

We seek self-motivated individuals who have strong training in epigenetics, chromatin remodeling, and transcriptional regulation and are interested in metabolism. A background on gastroenterology, particularly in gut microbiome and tumorigenesis, is a plus. Applicants must have a doctoral levels degree with less than five years of postdoctoral research experience.