Postdoctoral Fellow (NCATS)

The fellow will advance the i3D-RARE program, developing validated 3D cellular models (e.g., organoids, spheroids) from stem cells. These models serve as predictive assays, integrated with multiomics, to discover new drug targets and treatments for rare diseases. Join a dynamic, collaborative team dedicated to pioneering innovative disease modeling and accelerating preclinical drug discovery.

The selected candidate will:

• Work on the development and optimization of in vitro models of rare diseases using patient stem cells derived 2D cells and 3D organoids.
• Identify disease phenotypes and biomarkers using these patient stem cell-derived models.
• Learn and participate in the drug development process and will apply new technologies, such as patient iPSC-based disease modeling and 3D organoids, for the evaluation of drug efficacy and toxicity.
• Develop in vitro biochemical and cell-based assays for HTS of compound libraries to identify lead compounds, which will be used as tools to further understand disease pathophysiology and to be developed as therapeutics.
• Collaborate with researchers from other universities and NIH institutes and centers, and will present experimental findings at scientific conferences.

Upon completion of training, the fellow will have gained extensive experience and skills in translational research for drug discovery and development across a range of therapeutic modalities. The fellow will:

• Communicate results to project team members and collaborators and provide updates to senior management.
• Keep accurate and complete records of all scientific experiments according to established procedures
• Ensure that these records and raw data are properly retained.
• Write technical reports and manuscripts.

The ideal candidate should possess a doctoral degree (Ph.D.) with a background in cell biology, molecular biology, or pharmacology, and have a strong record of publishing research results in high-impact, peer-reviewed scientific journals.

Experience in human iPSC-related research or drug screening is preferred, although training in these areas will be provided.

Applicants should be independent thinkers and team players who are able to work in an interactive and fast-paced environment.

Candidates are expected to present results of ongoing work at meetings (e.g., internal group meetings, project team meetings and national conferences) and submit their work for publication in peer-reviewed scientific journals. Therefore, effective communication and presentation skills are required.

Applicants should be eligible to work in the United States for any employer.

U.S. citizens and permanent residents are eligible to apply. NIH welcomes foreign nationals with the exception of individuals from this list.