Postdoctoral Fellow - AD and FTD Research (Omics and Organoids)

The position is located in the Molecular Pathology Unit within the Center for Alzheimer’s and Related Dementias (CARD) at the NIH. The Molecular Pathology Unit is dedicated to deciphering the intricate molecular and cellular mechanisms underpinning neuronal and non-neuronal pathology in Alzheimer's disease (AD) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases.

To achieve this, the research unit employs a diverse range of techniques, including single-cell and spatial omics approaches in postmortem brain tissue as well as iPSC-derived human brain organoids.

We - the Molecular Pathology Unit (MPU) at Center for Alzheimer’s Disease and Related Dementias (CARD) - are on the lookout for a dedicated, innovative, and highly motivated postdoctoral researcher to pioneer spatial and single-cell omics techniques in conjunction with iPSC-derived organoid culture. Our research is centered on exploring the intricacies of neuronal vulnerability and the toxicity of non-neuronal cells in TDP-43 proteinopathies, which encompass Alzheimer's disease and Frontotemporal Dementia. At the core of our investigations lie human postmortem brain samples and brain organoids, aimed at achieving a profound understanding of the dynamic interplay among various cell types and the influence of genetic and environmental factors on the progression of these debilitating diseases.

The postdoctoral researcher will collaborate with other labs within and outside the NIH as well as with the CARD expert groups including the Single cell sequencing, Automated Cell culture and Advanced analytics expert groups.

What We Offer:

• Collaborative Environment: Join a dynamic team of researchers, and embark on a collective journey to advance our understanding of neurodegenerative diseases
• Cutting-Edge Technologies: Access state-of-the-art technologies and resources to support your research endeavors
• Supportive Work Environment: Enjoy a friendly, collaborative atmosphere that aligns with your research ambitions and offers a well-structured budget to facilitate your work

We invite applications from individuals with expertise in neurobiology, neuropathology, cell biology, and molecular biology. The ideal candidate should hold a PhD or MD/PhD and preferentially previous experience with human samples, iPSCs culture and/or bioinformatics.

Diversity is our strength, and we encourage candidates from diverse backgrounds to apply. We are committed to fostering an inclusive and equitable research environment.

The NIH is dedicated to building a diverse community in its training and employment programs.