Postdoctoral Fellow - Epigenetics, Gene Expression, and Aging

The Gene Regulation Section (GRS) within the Laboratory of Molecular Biology and Immunology (LMBI) at the National Institute on Aging (NIA), National Institutes of Health (NIH), investigates the epigenetic changes of the immunoglobulin heavy chain (IgH) gene locus prior to and during VDJ recombination. Our objective is to understand the molecular mechanism by which VDJ recombination is regulated.

We are seeking a motivated post-doctoral candidate to investigate epigenetic regulation of immune development, function, and aging. Ongoing research integrates genetic and epigenetic mechanisms of gene regulation. Studies in this section utilize a variety of genome-wide assays, including transcription factor binding, histone modifications, chromatin architecture, and DNA methylation in mouse strains that carry targeted mutations in genetic and epigenetic regulators. Single cell analyses are incorporated at all stages of the project.

Applicant must have a Ph.D. or equivalent graduate degree with a strong background in immunology and molecular biology, and evidence of prior research productivity. Prior experience in one or more of the following areas is essential: next generation sequencing, epigenetic assays, bio-informatic data analysis, flow cytometry, mouse handling, and cell culture techniques. The selected individual will join a highly cohesive team and must have demonstrated ability to work collaboratively.

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.